THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE
Identifieur interne : 003509 ( Main/Curation ); précédent : 003508; suivant : 003510THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE
Auteurs : L. Y. Lim [Singapour] ; M. L. Go [Singapour]Source :
- Clinical and Experimental Pharmacology and Physiology [ 0305-1870 ] ; 1985-10.
English descriptors
- Teeft :
- Agents actions, Amodiaquine, Amopyroquine, Anticholinesterase, Anticholinesterase activity, Antimalarial, Antimalarial drugs, Bche, Biochemical pharmacology, Bulletin world health organisation, Chloroquine, Chloroquine sulphate, Cholinesterase, Concentration range, Diamine oxidase, Dos, Enzyme systems, Histamine methylation, Inhibitory activity, Inhibitory potencies, Medicinal chemistry, Mefloquine, Mefloquine hydrochloride, National university, Ornithine decarboxylase activity, Other antimalarials, Pharmacology, Pharmacy pharmacology, Reaction velocity, Several antimalarials, Side effects, Sigma, Sigma chemical company, Sigma type, Singapore, System disturbances.
Abstract
1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.
Url:
DOI: 10.1111/j.1440-1681.1985.tb00904.x
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<term>Amopyroquine</term>
<term>Anticholinesterase</term>
<term>Anticholinesterase activity</term>
<term>Antimalarial</term>
<term>Antimalarial drugs</term>
<term>Bche</term>
<term>Biochemical pharmacology</term>
<term>Bulletin world health organisation</term>
<term>Chloroquine</term>
<term>Chloroquine sulphate</term>
<term>Cholinesterase</term>
<term>Concentration range</term>
<term>Diamine oxidase</term>
<term>Dos</term>
<term>Enzyme systems</term>
<term>Histamine methylation</term>
<term>Inhibitory activity</term>
<term>Inhibitory potencies</term>
<term>Medicinal chemistry</term>
<term>Mefloquine</term>
<term>Mefloquine hydrochloride</term>
<term>National university</term>
<term>Ornithine decarboxylase activity</term>
<term>Other antimalarials</term>
<term>Pharmacology</term>
<term>Pharmacy pharmacology</term>
<term>Reaction velocity</term>
<term>Several antimalarials</term>
<term>Side effects</term>
<term>Sigma</term>
<term>Sigma chemical company</term>
<term>Sigma type</term>
<term>Singapore</term>
<term>System disturbances</term>
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<front><div type="abstract" xml:lang="en">1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.</div>
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