THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE
Identifieur interne : 000539 ( Istex/Corpus ); précédent : 000538; suivant : 000540THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE
Auteurs : L. Y. Lim ; M. L. GoSource :
- Clinical and Experimental Pharmacology and Physiology [ 0305-1870 ] ; 1985-10.
English descriptors
- Teeft :
- Agents actions, Amodiaquine, Amopyroquine, Anticholinesterase, Anticholinesterase activity, Antimalarial, Antimalarial drugs, Bche, Biochemical pharmacology, Bulletin world health organisation, Chloroquine, Chloroquine sulphate, Cholinesterase, Concentration range, Diamine oxidase, Dos, Enzyme systems, Histamine methylation, Inhibitory activity, Inhibitory potencies, Medicinal chemistry, Mefloquine, Mefloquine hydrochloride, National university, Ornithine decarboxylase activity, Other antimalarials, Pharmacology, Pharmacy pharmacology, Reaction velocity, Several antimalarials, Side effects, Sigma, Sigma chemical company, Sigma type, Singapore, System disturbances.
Abstract
1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.
Url:
DOI: 10.1111/j.1440-1681.1985.tb00904.x
Links to Exploration step
ISTEX:90AF1A401D73691500AE4A31E30FC7AB4B5D1659Le document en format XML
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Lim</name><affiliation><mods:affiliation>Department of Pharmacy, National University of Singapore, Republic of Singapore</mods:affiliation></affiliation></author><author><name sortKey="Go, M L" sort="Go, M L" uniqKey="Go M" first="M. L." last="Go">M. L. Go</name><affiliation><mods:affiliation>Department of Pharmacy, National University of Singapore, Republic of Singapore</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Correspondence: Dr M. L. Go, Department of Pharmacy, National University of Singapore, Lower Kent Ridge Road, Republic of Singapore (0511).</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical and Experimental Pharmacology and Physiology</title><title level="j" type="alt">CLINICAL EXPERIMENTAL PHARMACOLOGY PHYSIOLOGY</title><idno type="ISSN">0305-1870</idno><idno type="eISSN">1440-1681</idno><imprint><biblScope unit="vol">12</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="527">527</biblScope><biblScope unit="page" to="531">531</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1985-10">1985-10</date></imprint><idno type="ISSN">0305-1870</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1870</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Agents actions</term><term>Amodiaquine</term><term>Amopyroquine</term><term>Anticholinesterase</term><term>Anticholinesterase activity</term><term>Antimalarial</term><term>Antimalarial drugs</term><term>Bche</term><term>Biochemical pharmacology</term><term>Bulletin world health organisation</term><term>Chloroquine</term><term>Chloroquine sulphate</term><term>Cholinesterase</term><term>Concentration range</term><term>Diamine oxidase</term><term>Dos</term><term>Enzyme systems</term><term>Histamine methylation</term><term>Inhibitory activity</term><term>Inhibitory potencies</term><term>Medicinal chemistry</term><term>Mefloquine</term><term>Mefloquine hydrochloride</term><term>National university</term><term>Ornithine decarboxylase activity</term><term>Other antimalarials</term><term>Pharmacology</term><term>Pharmacy pharmacology</term><term>Reaction velocity</term><term>Several antimalarials</term><term>Side effects</term><term>Sigma</term><term>Sigma chemical company</term><term>Sigma type</term><term>Singapore</term><term>System disturbances</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>mefloquine</json:string><json:string>chloroquine</json:string><json:string>antimalarial</json:string><json:string>amodiaquine</json:string><json:string>amopyroquine</json:string><json:string>anticholinesterase</json:string><json:string>bche</json:string><json:string>pharmacology</json:string><json:string>anticholinesterase activity</json:string><json:string>singapore</json:string><json:string>antimalarial drugs</json:string><json:string>system disturbances</json:string><json:string>national university</json:string><json:string>other antimalarials</json:string><json:string>cholinesterase</json:string><json:string>enzyme systems</json:string><json:string>several antimalarials</json:string><json:string>side effects</json:string><json:string>inhibitory potencies</json:string><json:string>diamine oxidase</json:string><json:string>ornithine decarboxylase activity</json:string><json:string>chloroquine sulphate</json:string><json:string>pharmacy pharmacology</json:string><json:string>sigma chemical company</json:string><json:string>inhibitory activity</json:string><json:string>sigma type</json:string><json:string>concentration range</json:string><json:string>reaction velocity</json:string><json:string>medicinal chemistry</json:string><json:string>mefloquine hydrochloride</json:string><json:string>bulletin world health organisation</json:string><json:string>biochemical pharmacology</json:string><json:string>agents actions</json:string><json:string>histamine methylation</json:string><json:string>sigma</json:string><json:string>dos</json:string></teeft></keywords><author><json:item><name>L. Y. Lim</name><affiliations><json:string>Department of Pharmacy, National University of Singapore, Republic of Singapore</json:string></affiliations></json:item><json:item><name>M. L. Go</name><affiliations><json:string>Department of Pharmacy, National University of Singapore, Republic of Singapore</json:string><json:string>Correspondence address: Correspondence: Dr M. L. Go, Department of Pharmacy, National University of Singapore, Lower Kent Ridge Road, Republic of Singapore (0511).</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>4‐aminoquinoline antimalarials</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cholinesterase inhibition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mefloquine.</value></json:item></subject><articleId><json:string>CEP527</json:string></articleId><arkIstex>ark:/67375/WNG-J7LH4CZ9-F</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.</abstract><qualityIndicators><score>4.714</score><pdfWordCount>1682</pdfWordCount><pdfCharCount>11076</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>468 x 684 pts</pdfPageSize><pdfWordsPerPage>336</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>86</abstractWordCount><abstractCharCount>608</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE</title><pmid><json:string>3878759</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical and Experimental Pharmacology and Physiology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1440-1681</json:string></doi><issn><json:string>0305-1870</json:string></issn><eissn><json:string>1440-1681</json:string></eissn><publisherId><json:string>CEP</json:string></publisherId><volume>12</volume><issue>5</issue><pages><first>527</first><last>531</last><total>5</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1985</json:string></date><geogName></geogName><orgName><json:string>World Bank</json:string><json:string>Sigma Chemical Company</json:string><json:string>UNDP/World Bank/WHO</json:string><json:string>Department of Pharmacy, National University of Singapore, Lower Ken</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Structuresare</json:string><json:string>Y. 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(1974)</json:string><json:string>Reynolds 1982</json:string><json:string>Cohn 1965</json:string><json:string>Konigk et al. 1981</json:string><json:string>Go (1948)</json:string><json:string>Wright and Sabine (1948)</json:string><json:string>Go et al. 1981</json:string><json:string>Wright & Sabine 1948</json:string><json:string>Steinberg et al. 1975</json:string><json:string>Famaey et al. 1975, 1977</json:string><json:string>Aviado et al. 1970</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-J7LH4CZ9-F</json:string></ark><categories><wos></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - physiology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Physiology (medical)</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Physiology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - toxicologie</json:string></inist></categories><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><doi><json:string>10.1111/j.1440-1681.1985.tb00904.x</json:string></doi><id>90AF1A401D73691500AE4A31E30FC7AB4B5D1659</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-J7LH4CZ9-F/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-J7LH4CZ9-F/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-J7LH4CZ9-F/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1985-10"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE</title><author xml:id="author-0000"><persName><forename type="first">L. 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L.</givenNames><familyName>Go</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="SG"><unparsedAffiliation>Department of Pharmacy, National University of Singapore, Republic of Singapore</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">4‐aminoquinoline antimalarials</keyword><keyword xml:id="k2">cholinesterase inhibition</keyword><keyword xml:id="k3">mefloquine.</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">SUMMARY</title><p>1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined.</p><p>2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine.</p><p>3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE</title></titleInfo><name type="personal"><namePart type="given">L. Y.</namePart><namePart type="family">Lim</namePart><affiliation>Department of Pharmacy, National University of Singapore, Republic of Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Go</namePart><affiliation>Department of Pharmacy, National University of Singapore, Republic of Singapore</affiliation><affiliation>Correspondence address: Correspondence: Dr M. L. Go, Department of Pharmacy, National University of Singapore, Lower Kent Ridge Road, Republic of Singapore (0511).</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1985-10</dateIssued><edition>Received 18 January 1985; revision received 17 April 1985</edition><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">17</extent><extent unit="linksCrossRef">3</extent></physicalDescription><abstract lang="en">1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.</abstract><subject lang="en"><genre>keywords</genre><topic>4‐aminoquinoline antimalarials</topic><topic>cholinesterase inhibition</topic><topic>mefloquine.</topic></subject><relatedItem type="host"><titleInfo><title>Clinical and Experimental Pharmacology and Physiology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0305-1870</identifier><identifier type="eISSN">1440-1681</identifier><identifier type="DOI">10.1111/(ISSN)1440-1681</identifier><identifier type="PublisherID">CEP</identifier><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>527</start><end>531</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Cardiopulmonary effects of antimalarial drugs. 1. 4‐aminoquinolines</title></titleInfo><name type="personal"><namePart type="given">D.M.</namePart><namePart type="family">Aviado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sadavongvivad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Cambar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Aviado, D.M., Sadavongvivad, C. & Cambar, P. (1970) Cardiopulmonary effects of antimalarial drugs. 1. 4‐aminoquinolines. Toxicology & Applied Pharmacology, 17, 107–117.</note><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>107</start><end>117</end></extent></part><relatedItem type="host"><titleInfo><title>Toxicology & Applied Pharmacology</title></titleInfo><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>107</start><end>117</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Inhibition of histamine methylation by antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">V.H.</namePart><namePart type="family">Cohn</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cohn, V.H. (1965) Inhibition of histamine methylation by antimalarial drugs. Biochemical Pharmacology, 14, 1686–1688.</note><part><date>1965</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1686</start><end>1688</end></extent></part><relatedItem type="host"><titleInfo><title>Biochemical Pharmacology</title></titleInfo><part><date>1965</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1686</start><end>1688</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Single dose therapy of falciparum malaria with malaria or pyrimethamine‐sulfadoxine</title></titleInfo><name type="personal"><namePart type="given">E.B.</namePart><namePart type="family">Doberstyn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Phintuyothin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Noeypatimanondh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Terrakiartkamjorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Doberstyn, E.B., Phintuyothin, P., Noeypatimanondh, S. & Terrakiartkamjorn, C. (1979) Single dose therapy of falciparum malaria with malaria or pyrimethamine‐sulfadoxine. Bulletin World Health Organisation, 57, 275–279.</note><part><date>1979</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><extent unit="pages"><start>275</start><end>279</end></extent></part><relatedItem type="host"><titleInfo><title>Bulletin World Health Organisation</title></titleInfo><part><date>1979</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><extent unit="pages"><start>275</start><end>279</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Inhibiting effects of morphine, chloroquine, nonsteroidal and steroidal antiinflammatory drugs on electrically induced contractions of guinea pig ileum and the reversing effect of prostaglandins</title></titleInfo><name type="personal"><namePart type="given">J.P.</namePart><namePart type="family">Famaey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Fontaine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Reuse</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Famaey, J.P., Fontaine, J. & Reuse, R. (1975) Inhibiting effects of morphine, chloroquine, nonsteroidal and steroidal antiinflammatory drugs on electrically induced contractions of guinea pig ileum and the reversing effect of prostaglandins. Agents & Actions, 5, 354–358.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>354</start><end>358</end></extent></part><relatedItem type="host"><titleInfo><title>Agents & Actions</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>354</start><end>358</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>An analysis of the inhibitory effects and of possible prostaglandins antagonism of chloroquine in the guinea pig isolated ileum</title></titleInfo><name type="personal"><namePart type="given">J.P.</namePart><namePart type="family">Famaey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Fontaine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Reuse</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Famaey, J.P., Fontaine, J. & Reuse, R. (1977) An analysis of the inhibitory effects and of possible prostaglandins antagonism of chloroquine in the guinea pig isolated ileum. Journal of Pharmacy & Pharmacology, 29, 761–762.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>761</start><end>762</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Pharmacy & Pharmacology</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>761</start><end>762</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Investigation of the anti‐acetylcholinesterase activities of the antimalarial agent amodiaquine and related compounds</title></titleInfo><name type="personal"><namePart type="given">M.L.</namePart><namePart type="family">Go</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.L.</namePart><namePart type="family">Ngiam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.S.C.</namePart><namePart type="family">Wan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Go, M.L., Ngiam, T.L. & Wan, A.S.C. (1981) Investigation of the anti‐acetylcholinesterase activities of the antimalarial agent amodiaquine and related compounds. Southeast Asian Journal of Tropical Medicine and Public Health, 12, 37–41.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>37</start><end>41</end></extent></part><relatedItem type="host"><titleInfo><title>Southeast Asian Journal of Tropical Medicine and Public Health</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>37</start><end>41</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>ROSFIT: An enzyme kinetics nonlinear regression curve fitting package for a microcomputer</title></titleInfo><name type="personal"><namePart type="given">W.R.</namePart><namePart type="family">Greco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.L.</namePart><namePart type="family">Priore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sharma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Korytnyk</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Greco, W.R., Priore, R.L., Sharma, M. & Korytnyk, W. (1982) ROSFIT: An enzyme kinetics nonlinear regression curve fitting package for a microcomputer. Computers & Biomedical Research, 15, 39–45.</note><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>39</start><end>45</end></extent></part><relatedItem type="host"><titleInfo><title>Computers & Biomedical Research</title></titleInfo><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>39</start><end>45</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Enzyme inhibitory action of tetrahydroaminoacridine and its structural fragments</title></titleInfo><name type="personal"><namePart type="given">P.N.</namePart><namePart type="family">Kaul</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kaul, P.N. (1962) Enzyme inhibitory action of tetrahydroaminoacridine and its structural fragments. Journal of Pharmacy & Pharmacology, 14, 243–248.</note><part><date>1962</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>243</start><end>248</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Pharmacy & Pharmacology</title></titleInfo><part><date>1962</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>243</start><end>248</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Plasmodium chabaudi infection of mice: Effects of chloroquine and mefloquine: Inhibition of Ornithine decarboxylase activity</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Konigk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Mirtsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Putfarken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Abdel Rasoul</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Konigk, E., Mirtsch, S., Putfarken, B. & Abdel Rasoul, S. (1981) Plasmodium chabaudi infection of mice: Effects of chloroquine and mefloquine: Inhibition of Ornithine decarboxylase activity. Tropenmedizin und Parasitologie, 32, 73–76.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>73</start><end>76</end></extent></part><relatedItem type="host"><titleInfo><title>Tropenmedizin und Parasitologie</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>73</start><end>76</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Inhibition of diamine oxidase by antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.L.</namePart><namePart type="family">Sourkes</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ma, K. & Sourkes, T.L. (1980) Inhibition of diamine oxidase by antimalarial drugs. Agents & Actions, 10, 395–398.</note><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>395</start><end>398</end></extent></part><relatedItem type="host"><titleInfo><title>Agents & Actions</title></titleInfo><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>395</start><end>398</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Stereospecificity of hydrolytic enzymes in reaction with optically active organophosphorus compounds. I. The reaction of cholinesterases and paraoxonase with S‐alkyl p‐nitrophenylmethylphosphonothionates</title></titleInfo><name type="personal"><namePart type="given">A.J.J.</namePart><namePart type="family">Ooms</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.L.</namePart><namePart type="family">Bolter</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ooms, A.J.J. & Bolter, H.L. (1964) Stereospecificity of hydrolytic enzymes in reaction with optically active organophosphorus compounds. I. The reaction of cholinesterases and paraoxonase with S‐alkyl p‐nitrophenylmethylphosphonothionates. Biochemical Pharmacology, 14, 1839–1845.</note><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1839</start><end>1845</end></extent></part><relatedItem type="host"><titleInfo><title>Biochemical Pharmacology</title></titleInfo><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1839</start><end>1845</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Chloroquine and other antimalarials</title></titleInfo><name type="personal"><namePart type="given">J.E.F.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Martindale: The Extra Pharmacopoeia</title></titleInfo><originInfo><publisher>The Pharmaceutical Press</publisher></originInfo><part><date>1982</date></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug resistant malaria</title></titleInfo><name type="personal"><namePart type="given">K.H.</namePart><namePart type="family">Rieckmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.M.</namePart><namePart type="family">Trenholme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.L.</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.E.</namePart><namePart type="family">Carson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Frischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.E.</namePart><namePart type="family">Desjardins</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rieckmann, K.H., Trenholme, G.M., Williams, R.L., Carson, P.E., Frischer, H. & Desjardins, R.E. (1974) Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug resistant malaria. 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Journal of Medicinal Chemistry, 17, 8–12.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>8</start><end>12</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Medicinal Chemistry</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>8</start><end>12</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>A hydrophobic binding site in AChE</title></titleInfo><name type="personal"><namePart type="given">G.M.</namePart><namePart type="family">Steinberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.L.</namePart><namePart type="family">Mednick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Maddox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Rice</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Cramer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Steinberg, G.M., Mednick, M.L., Maddox, J., Rice, R. & Cramer, J. 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Bulletin World Health Organisation, 61, 169–178.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>169</start><end>178</end></extent></part><relatedItem type="host"><titleInfo><title>Bulletin World Health Organisation</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>169</start><end>178</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Cholinesterases of human erythrocytes and plasma and their inhibition by antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">W.I.</namePart><namePart type="family">Wright</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.C.</namePart><namePart type="family">Sabine</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wright, W.I. & Sabine, J.C. (1948) Cholinesterases of human erythrocytes and plasma and their inhibition by antimalarial drugs. Journal of Pharmacology & Experimental Therapeutics, 93, 230–239.</note><part><date>1948</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>230</start><end>239</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Pharmacology & Experimental Therapeutics</title></titleInfo><part><date>1948</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>230</start><end>239</end></extent></part></relatedItem></relatedItem><identifier type="istex">90AF1A401D73691500AE4A31E30FC7AB4B5D1659</identifier><identifier type="ark">ark:/67375/WNG-J7LH4CZ9-F</identifier><identifier type="DOI">10.1111/j.1440-1681.1985.tb00904.x</identifier><identifier type="ArticleID">CEP527</identifier><accessCondition type="use and reproduction" contentType="copyright">© Wiley. 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