Targeting the lysosome in cancer
Identifieur interne : 000D87 ( Main/Curation ); précédent : 000D86; suivant : 000D88Targeting the lysosome in cancer
Auteurs : Shengfu Piao [États-Unis] ; Ravi K. Amaravadi [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2016-05.
Abstract
Lysosomes are membrane‐bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over the last decade, advances in lysosome research have established a broad role for the lysosome in the pathophysiology of disease. In this review, we highlight the recent discoveries in lysosome biology, with an emphasis on their implications for cancer therapy. We focus on targeting the lysosome in cancer by exploring lysosomal biogenesis and its role in the crosstalk between apoptosis and autophagy. We also discuss how lysosomal inhibition could emerge as a new therapeutic strategy to overcome drug resistance in cancer.
Url:
DOI: 10.1111/nyas.12953
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C72
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000C72
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000006
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000D88
Links to Exploration step
ISTEX:52244FD8572E0927E7BCFCDFF5F15A80C164EE1CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting the lysosome in cancer</title>
<author><name sortKey="Piao, Shengfu" sort="Piao, Shengfu" uniqKey="Piao S" first="Shengfu" last="Piao">Shengfu Piao</name>
</author>
<author><name sortKey="Amaravadi, Ravi K" sort="Amaravadi, Ravi K" uniqKey="Amaravadi R" first="Ravi K." last="Amaravadi">Ravi K. Amaravadi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:52244FD8572E0927E7BCFCDFF5F15A80C164EE1C</idno>
<date when="2016" year="2016">2016</date>
<idno type="doi">10.1111/nyas.12953</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-K2PV672D-N/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C72</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C72</idno>
<idno type="wicri:Area/Istex/Curation">000C72</idno>
<idno type="wicri:Area/Istex/Checkpoint">000006</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000006</idno>
<idno type="wicri:doubleKey">0077-8923:2016:Piao S:targeting:the:lysosome</idno>
<idno type="wicri:Area/Main/Merge">000D88</idno>
<idno type="wicri:Area/Main/Curation">000D87</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Targeting the lysosome in cancer</title>
<author><name sortKey="Piao, Shengfu" sort="Piao, Shengfu" uniqKey="Piao S" first="Shengfu" last="Piao">Shengfu Piao</name>
<affiliation wicri:level="3"><country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Amaravadi, Ravi K" sort="Amaravadi, Ravi K" uniqKey="Amaravadi R" first="Ravi K." last="Amaravadi">Ravi K. Amaravadi</name>
<affiliation wicri:level="3"><country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Annals of the New York Academy of Sciences</title>
<title level="j" type="sub">Targeting the Lysosome</title>
<title level="j" type="alt">ANNALS OF THE NEW YORK ACADEMY OF SCIENCES</title>
<idno type="ISSN">0077-8923</idno>
<idno type="eISSN">1749-6632</idno>
<imprint><biblScope unit="vol">1371</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="45">45</biblScope>
<biblScope unit="page" to="54">54</biblScope>
<biblScope unit="page-count">10</biblScope>
<date type="published" when="2016-05">2016-05</date>
</imprint>
<idno type="ISSN">0077-8923</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0077-8923</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Lysosomes are membrane‐bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over the last decade, advances in lysosome research have established a broad role for the lysosome in the pathophysiology of disease. In this review, we highlight the recent discoveries in lysosome biology, with an emphasis on their implications for cancer therapy. We focus on targeting the lysosome in cancer by exploring lysosomal biogenesis and its role in the crosstalk between apoptosis and autophagy. We also discuss how lysosomal inhibition could emerge as a new therapeutic strategy to overcome drug resistance in cancer.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000D87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:52244FD8572E0927E7BCFCDFF5F15A80C164EE1C |texte= Targeting the lysosome in cancer }}
This area was generated with Dilib version V0.6.33. |