ChloroquineV1, Istex, Corpus, bibRecord, 000C72

Targeting the lysosome in cancer

Identifieur interne : 000C72 ( Istex/Corpus ); précédent : 000C71; suivant : 000C73

Targeting the lysosome in cancer

Auteurs : Shengfu Piao ; Ravi K. Amaravadi

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2016-05.

RBID : ISTEX:52244FD8572E0927E7BCFCDFF5F15A80C164EE1C

Abstract

Lysosomes are membrane‐bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over the last decade, advances in lysosome research have established a broad role for the lysosome in the pathophysiology of disease. In this review, we highlight the recent discoveries in lysosome biology, with an emphasis on their implications for cancer therapy. We focus on targeting the lysosome in cancer by exploring lysosomal biogenesis and its role in the crosstalk between apoptosis and autophagy. We also discuss how lysosomal inhibition could emerge as a new therapeutic strategy to overcome drug resistance in cancer.

Url:

https://api.istex.fr/ark:/67375/WNG-K2PV672D-N/fulltext.pdf

DOI: 10.1111/nyas.12953

Links to Exploration step

ISTEX:52244FD8572E0927E7BCFCDFF5F15A80C164EE1C

Le document en format XML

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Targeting the lysosome in cancer

Targeting the lysosome in cancer

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