The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo
Identifieur interne : 002B11 ( Istex/Curation ); précédent : 002B10; suivant : 002B12The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo
Auteurs : Igor B. Roninson [États-Unis]Source :
- Biochemical Pharmacology [ 0006-2952 ] ; 1992.
English descriptors
- KwdEn :
- PCR.
- Teeft :
- Acad, Assay, Biol, Biol chem, Bone marrow, Carcinoma, Carcinoma cells, Cdna, Cell biol, Cell line, Cell lines, Cellular biology, Chemotherapy, Clinical cancer, Coding sequence, Colchicine, Cytotoxic, Cytotoxic selection, Different drugs, Different types, Drug selection, Efflux, Functional role, Gene, Gene family, Gottesman, Gros, Hematopoietic, Hematopoietic progenitor cells, High levels, Highest levels, Human cells, Immunohistochemical, Infectants, Mdr1, Mdr1 expression, Mdr1 gene, Mdr2, Mdrl, Mdrl gene, Multidrug, Multidrug resistance, Multidrug resistance gene, Multidrug resistance gene product, Mutant, Mutant protein, Mutation, Natl, Natl cancer inst, Neoplastic transformation, Normal tissues, Pastan, Pglycoprotein, Pglycoprotein inhibitors, Phenotype, Plenum, Plenum press, Point mutations, Preferential resistance, Proc, Proc natl acad, Roninson, Selective agent, Subpopulation, Tumor cells, Unpublished data, Untreated, Untreated tumors.
Abstract
Abstract: This review describes the studies that address the role of the MDR1 (P-glycoprotein) gene in multidrug resistance in cell lines selected in vitro and in clinical cancer. Molecular genetic studies have demonstrated that expression of P-glycoprotein, an efflux pump acting at diverse lipophilic compounds, is sufficient to provide resistance to a large number of lipophilic drugs in tissue culture. The MDR1 gene is expressed in several normal human tissues associated with secretory or barrier functions and in some bone marrow and blood cells, including hematopoietic progenitor cells. MDR1 expression in clinical cancer is often found in untreated tumors of different types. Several studies showed a correlation between MDR1 expression and tumor resistance to combination chemotherapy. MDR1 expression in untreated tumors may reflect their origin from MDR1-positive normal cells or cellular changes associated with neoplastic transformation or progression. MDR1 expression in some types of cancer may be a marker of a more aggressive subpopulation of tumor cells, possessing multiple mechanisms for resistance to treatment.
Url:
DOI: 10.1016/0006-2952(92)90666-7
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<front><div type="abstract" xml:lang="en">Abstract: This review describes the studies that address the role of the MDR1 (P-glycoprotein) gene in multidrug resistance in cell lines selected in vitro and in clinical cancer. Molecular genetic studies have demonstrated that expression of P-glycoprotein, an efflux pump acting at diverse lipophilic compounds, is sufficient to provide resistance to a large number of lipophilic drugs in tissue culture. The MDR1 gene is expressed in several normal human tissues associated with secretory or barrier functions and in some bone marrow and blood cells, including hematopoietic progenitor cells. MDR1 expression in clinical cancer is often found in untreated tumors of different types. Several studies showed a correlation between MDR1 expression and tumor resistance to combination chemotherapy. MDR1 expression in untreated tumors may reflect their origin from MDR1-positive normal cells or cellular changes associated with neoplastic transformation or progression. MDR1 expression in some types of cancer may be a marker of a more aggressive subpopulation of tumor cells, possessing multiple mechanisms for resistance to treatment.</div>
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