Severe postoperative wound healing disturbance in a patient with alpha‐1‐antitrypsin deficiency: the impact of augmentation therapy
Identifieur interne : 002367 ( Istex/Curation ); précédent : 002366; suivant : 002368Severe postoperative wound healing disturbance in a patient with alpha‐1‐antitrypsin deficiency: the impact of augmentation therapy
Auteurs : Marionna Cathomas [Suisse] ; Alexandra Schüller [Suisse] ; Daniel Candinas [Suisse] ; Roman Inglin [Suisse]Source :
- International Wound Journal [ 1742-4801 ] ; 2015-10.
Abstract
Wound healing disturbance is a common complication following surgery, but the underlying cause sometimes remains elusive. A 50‐year‐old Caucasian male developed an initially misunderstood severe wound healing disturbance following colon and abdominal wall surgery. An untreated alpha‐1‐antitrypsin (AAT) deficiency in the patient's medical history, known since 20 years and clinically apparent as a mild to moderate chronic obstructive pulmonary disease, was eventually found to be at its origin. Further clinical work‐up showed AAT serum levels below 30% of the lower reference value; phenotype testing showed a ZZ phenotype and a biopsy taken from the wound area showed the characteristic, disease‐related histological pattern of necrotising panniculitits. Augmentation therapy with plasma AAT was initiated and within a few weeks, rapid and adequate would healing was observed. AAT deficiency is an uncommon but clinically significant, possible cause of wound healing disturbances. An augmentation therapy ought to be considered in affected patients during the perioperative period.
Url:
DOI: 10.1111/iwj.12419
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002367
Links to Exploration step
ISTEX:C21189B2D72B80867F154C25EFC27CC2B46E13D6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe postoperative wound healing disturbance in a patient with alpha‐1‐antitrypsin deficiency: the impact of augmentation therapy</title>
<author><name sortKey="Cathomas, Marionna" sort="Cathomas, Marionna" uniqKey="Cathomas M" first="Marionna" last="Cathomas">Marionna Cathomas</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schuller, Alexandra" sort="Schuller, Alexandra" uniqKey="Schuller A" first="Alexandra" last="Schüller">Alexandra Schüller</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Candinas, Daniel" sort="Candinas, Daniel" uniqKey="Candinas D" first="Daniel" last="Candinas">Daniel Candinas</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Inglin, Roman" sort="Inglin, Roman" uniqKey="Inglin R" first="Roman" last="Inglin">Roman Inglin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Dr. R Inglin, MDDepartment of Visceral Surgery and MedicineBern University HospitalFreiburgstrasse 10CH‐3010 BernSwitzerlandE‐mail:</mods:affiliation>
<wicri:noCountry code="subField">BernSwitzerlandE‐mail:</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: roman.inglin@insel.ch</mods:affiliation>
<country wicri:rule="url">Suisse</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C21189B2D72B80867F154C25EFC27CC2B46E13D6</idno>
<date when="2015" year="2015">2015</date>
<idno type="doi">10.1111/iwj.12419</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-X4XW7MDH-7/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002367</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002367</idno>
<idno type="wicri:Area/Istex/Curation">002367</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Severe postoperative wound healing disturbance in a patient with alpha‐1‐antitrypsin deficiency: the impact of augmentation therapy</title>
<author><name sortKey="Cathomas, Marionna" sort="Cathomas, Marionna" uniqKey="Cathomas M" first="Marionna" last="Cathomas">Marionna Cathomas</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schuller, Alexandra" sort="Schuller, Alexandra" uniqKey="Schuller A" first="Alexandra" last="Schüller">Alexandra Schüller</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Candinas, Daniel" sort="Candinas, Daniel" uniqKey="Candinas D" first="Daniel" last="Candinas">Daniel Candinas</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Inglin, Roman" sort="Inglin, Roman" uniqKey="Inglin R" first="Roman" last="Inglin">Roman Inglin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern, Switzerland</mods:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Visceral Surgery and Medicine, University Hospital of Bern, Bern</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Dr. R Inglin, MDDepartment of Visceral Surgery and MedicineBern University HospitalFreiburgstrasse 10CH‐3010 BernSwitzerlandE‐mail:</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: roman.inglin@insel.ch</mods:affiliation>
<country wicri:rule="url">Suisse</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">International Wound Journal</title>
<title level="j" type="alt">INTERNATIONAL WOUND JOURNAL</title>
<idno type="ISSN">1742-4801</idno>
<idno type="eISSN">1742-481X</idno>
<imprint><biblScope unit="vol">12</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="601">601</biblScope>
<biblScope unit="page" to="604">604</biblScope>
<biblScope unit="page-count">4</biblScope>
<publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2015-10">2015-10</date>
</imprint>
<idno type="ISSN">1742-4801</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1742-4801</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Wound healing disturbance is a common complication following surgery, but the underlying cause sometimes remains elusive. A 50‐year‐old Caucasian male developed an initially misunderstood severe wound healing disturbance following colon and abdominal wall surgery. An untreated alpha‐1‐antitrypsin (AAT) deficiency in the patient's medical history, known since 20 years and clinically apparent as a mild to moderate chronic obstructive pulmonary disease, was eventually found to be at its origin. Further clinical work‐up showed AAT serum levels below 30% of the lower reference value; phenotype testing showed a ZZ phenotype and a biopsy taken from the wound area showed the characteristic, disease‐related histological pattern of necrotising panniculitits. Augmentation therapy with plasma AAT was initiated and within a few weeks, rapid and adequate would healing was observed. AAT deficiency is an uncommon but clinically significant, possible cause of wound healing disturbances. An augmentation therapy ought to be considered in affected patients during the perioperative period.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002367 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002367 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:C21189B2D72B80867F154C25EFC27CC2B46E13D6 |texte= Severe postoperative wound healing disturbance in a patient with alpha‐1‐antitrypsin deficiency: the impact of augmentation therapy }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |