Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species
Identifieur interne : 001367 ( Istex/Curation ); précédent : 001366; suivant : 001368Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species
Auteurs : Renate Lüllmann-Rauch [Allemagne] ; Gert-Hinrich Reil [Allemagne]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1974.
English descriptors
- Teeft :
- Acta pathol, Adrenal, Adrenal cortex, Adrenal glands, Adrenal medulla, Adrenocortical cell, Alveolar epithelial cells, Alveolar macrophage, Alveolar macrophages, Alveolar spaces, Amphiphilic, Amphiphilic compound, Amphiphilic compounds, Animal wasallowed, Body weights, Cell types, Chlorphentermine, Concentric lamellae, Control animals, Cortical cells, Drug administration, Drug treatment, Foam cells, Generalized phenomenon, Generalized phospholipidosis, Guinea, Guinea pigs, High magnification, Hruban, Inclusion, Intralysosomal accumulation, Lamella, Lamellar, Lamellar bodies, Lamellated, Lysosomal, Lysosomelike bodies, Macrophage, Many inclusions, Matrix, Medullary cells, Numerous lamellated inclusions, Other organs, Other tissues, Paraffin section, Paraffin sections, Pathol, Phospholipidosis, Present study, Pulmonary tissues, Recoverafter cessationof drug treatment, Reil, Retina, Small cubes, Tricyclic antidepressants, Ultrastructural, Ultrastructural alterations, Ultrastructural appearance, Unit membrane, Virchows arch, West germany, Zona, Zona fasciculata, Zona glomerulosa, Zona reticularis.
Abstract
Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.
Url:
DOI: 10.1016/0041-008X(74)90263-4
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<term>Adrenal</term>
<term>Adrenal cortex</term>
<term>Adrenal glands</term>
<term>Adrenal medulla</term>
<term>Adrenocortical cell</term>
<term>Alveolar epithelial cells</term>
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<term>Amphiphilic compounds</term>
<term>Animal wasallowed</term>
<term>Body weights</term>
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<term>Chlorphentermine</term>
<term>Concentric lamellae</term>
<term>Control animals</term>
<term>Cortical cells</term>
<term>Drug administration</term>
<term>Drug treatment</term>
<term>Foam cells</term>
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<term>Generalized phospholipidosis</term>
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<term>Guinea pigs</term>
<term>High magnification</term>
<term>Hruban</term>
<term>Inclusion</term>
<term>Intralysosomal accumulation</term>
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<term>Lamellated</term>
<term>Lysosomal</term>
<term>Lysosomelike bodies</term>
<term>Macrophage</term>
<term>Many inclusions</term>
<term>Matrix</term>
<term>Medullary cells</term>
<term>Numerous lamellated inclusions</term>
<term>Other organs</term>
<term>Other tissues</term>
<term>Paraffin section</term>
<term>Paraffin sections</term>
<term>Pathol</term>
<term>Phospholipidosis</term>
<term>Present study</term>
<term>Pulmonary tissues</term>
<term>Recoverafter cessationof drug treatment</term>
<term>Reil</term>
<term>Retina</term>
<term>Small cubes</term>
<term>Tricyclic antidepressants</term>
<term>Ultrastructural</term>
<term>Ultrastructural alterations</term>
<term>Ultrastructural appearance</term>
<term>Unit membrane</term>
<term>Virchows arch</term>
<term>West germany</term>
<term>Zona</term>
<term>Zona fasciculata</term>
<term>Zona glomerulosa</term>
<term>Zona reticularis</term>
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<front><div type="abstract" xml:lang="en">Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.</div>
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