Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species
Identifieur interne : 001367 ( Istex/Corpus ); précédent : 001366; suivant : 001368Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species
Auteurs : Renate Lüllmann-Rauch ; Gert-Hinrich ReilSource :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1974.
English descriptors
- Teeft :
- Acta pathol, Adrenal, Adrenal cortex, Adrenal glands, Adrenal medulla, Adrenocortical cell, Alveolar epithelial cells, Alveolar macrophage, Alveolar macrophages, Alveolar spaces, Amphiphilic, Amphiphilic compound, Amphiphilic compounds, Animal wasallowed, Body weights, Cell types, Chlorphentermine, Concentric lamellae, Control animals, Cortical cells, Drug administration, Drug treatment, Foam cells, Generalized phenomenon, Generalized phospholipidosis, Guinea, Guinea pigs, High magnification, Hruban, Inclusion, Intralysosomal accumulation, Lamella, Lamellar, Lamellar bodies, Lamellated, Lysosomal, Lysosomelike bodies, Macrophage, Many inclusions, Matrix, Medullary cells, Numerous lamellated inclusions, Other organs, Other tissues, Paraffin section, Paraffin sections, Pathol, Phospholipidosis, Present study, Pulmonary tissues, Recoverafter cessationof drug treatment, Reil, Retina, Small cubes, Tricyclic antidepressants, Ultrastructural, Ultrastructural alterations, Ultrastructural appearance, Unit membrane, Virchows arch, West germany, Zona, Zona fasciculata, Zona glomerulosa, Zona reticularis.
Abstract
Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.
Url:
DOI: 10.1016/0041-008X(74)90263-4
Links to Exploration step
ISTEX:AA5FBAF28D1584F5CF7BE5BBA53FB7BFCC353283Le document en format XML
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Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. 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(1973a)</json:string><json:string>Blessing and Lenz, 1973</json:string><json:string>Hruban et al. (1972a)</json:string><json:string>Bertalanffy, 1964</json:string><json:string>Lullmann-Rauch et al. (1972)</json:string><json:string>Theiss et al. (1973)</json:string><json:string>Shikata et al., 1972</json:string><json:string>Shikata et al. (1970, 1972)</json:string><json:string>Hruban et al. (1972b)</json:string><json:string>Lullmann-Rauch et al. (1973)</json:string><json:string>Ltillmann-Rauch et al., 1972</json:string><json:string>Adachi et al. (1972)</json:string><json:string>Ltillmann-Rauch and Reil, 1973</json:string><json:string>Abraham et al. (1968)</json:string><json:string>Suzuki et al. (1973)</json:string><json:string>Lullmann-Rauch and Reil, 1973</json:string><json:string>Velo and Spector, 1973</json:string><json:string>Lullmann et al. 1973a</json:string><json:string>Vijeyaratnam and Corrin (1972)</json:string><json:string>Yates et al. (1967)</json:string><json:string>Liillmann and Liillmann-Rauch, 1974</json:string><json:string>Shikata et al. (1972)</json:string><json:string>Ltillmann-Rauch et al. 1972</json:string><json:string>Yamamoto et al. (1970, 1971)</json:string><json:string>Vijeyaratnam and Corrin, 1972</json:string><json:string>Lullmann et al., 1973</json:string><json:string>Corrin and King, 1969</json:string><json:string>Abraham and Hendy (1970)</json:string><json:string>Ltillmann and Lullmann-Rauch (1974)</json:string><json:string>Schutta and Neville (1968)</json:string><json:string>Bowden, 1971</json:string><json:string>Kikkawa and Suzuki (1972)</json:string><json:string>Parwaresch et al. (1973)</json:string><json:string>Ltillmann-Rauch et al. (1973)</json:string><json:string>Seydel and Wassermann, 1973</json:string><json:string>Hruban et al. (1973)</json:string><json:string>Rauch et al., 1972</json:string><json:string>Gregory et al. (1970)</json:string><json:string>Dietert and Scallen (1969)</json:string><json:string>Read and Bay (1971)</json:string><json:string>Liillmann et al., 1973</json:string><json:string>Hruban et al., 1972a</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-RFWFJH06-H</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - toxicology</json:string><json:string>2 - pharmacology & pharmacy</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - toxicology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Toxicology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - techniques d'exploration et de diagnostic (generalites)</json:string></inist></categories><publicationDate>1974</publicationDate><copyrightDate>1974</copyrightDate><doi><json:string>10.1016/0041-008X(74)90263-4</json:string></doi><id>AA5FBAF28D1584F5CF7BE5BBA53FB7BFCC353283</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-RFWFJH06-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-RFWFJH06-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-RFWFJH06-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1974</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species</title><author xml:id="author-0000"><persName><forename type="first">Renate</forename><surname>Lüllmann-Rauch</surname></persName><affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</affiliation><affiliation>Department of Pharmacology, University of Kiel, Kiel, West Germany</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Gert-Hinrich</forename><surname>Reil</surname></persName><affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</affiliation><affiliation>Department of Pharmacology, University of Kiel, Kiel, West Germany</affiliation></author><idno type="istex">AA5FBAF28D1584F5CF7BE5BBA53FB7BFCC353283</idno><idno type="ark">ark:/67375/6H6-RFWFJH06-H</idno><idno type="DOI">10.1016/0041-008X(74)90263-4</idno><idno type="PII">0041-008X(74)90263-4</idno></analytic><monogr><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="pISSN">0041-008X</idno><idno type="PII">S0041-008X(00)X0291-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1974"></date><biblScope unit="volume">30</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="408">408</biblScope><biblScope unit="page" to="421">421</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1974</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.</p></abstract></profileDesc><revisionDesc><change when="1974">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-RFWFJH06-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YTAAP</jid><aid>74902634</aid><ce:pii>0041-008X(74)90263-4</ce:pii><ce:doi>10.1016/0041-008X(74)90263-4</ce:doi><ce:copyright type="unknown" year="1974"></ce:copyright></item-info><head><ce:title>Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species</ce:title><ce:author-group><ce:author><ce:given-name>Renate</ce:given-name><ce:surname>Lüllmann-Rauch</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Gert-Hinrich</ce:given-name><ce:surname>Reil</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Anatomy, University of Kiel, Kiel, West Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Pharmacology, University of Kiel, Kiel, West Germany</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="6" month="2" year="1974"></ce:date-received><ce:date-accepted day="10" month="4" year="1974"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species</title></titleInfo><name type="personal"><namePart type="given">Renate</namePart><namePart type="family">Lüllmann-Rauch</namePart><affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</affiliation><affiliation>Department of Pharmacology, University of Kiel, Kiel, West Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gert-Hinrich</namePart><namePart type="family">Reil</namePart><affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</affiliation><affiliation>Department of Pharmacology, University of Kiel, Kiel, West Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1974</dateIssued><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.</abstract><relatedItem type="host"><titleInfo><title>Toxicology and Applied Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>YTAAP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1974</dateIssued></originInfo><identifier type="ISSN">0041-008X</identifier><identifier type="PII">S0041-008X(00)X0291-8</identifier><part><date>1974</date><detail type="volume"><number>30</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>337</start><end>485</end></extent><extent unit="pages"><start>408</start><end>421</end></extent></part></relatedItem><identifier type="istex">AA5FBAF28D1584F5CF7BE5BBA53FB7BFCC353283</identifier><identifier type="ark">ark:/67375/6H6-RFWFJH06-H</identifier><identifier type="DOI">10.1016/0041-008X(74)90263-4</identifier><identifier type="PII">0041-008X(74)90263-4</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-RFWFJH06-H/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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