Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)
Identifieur interne : 001144 ( Istex/Curation ); précédent : 001143; suivant : 001145Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)
Auteurs : Jean Gustave Tangmouo [Cameroun, Suisse] ; Raimana Ho [Suisse] ; An Matheeussen [Belgique] ; Alain Meli Lannang [Cameroun] ; Justin Komguem [Cameroun] ; Bernadette Biloa Messi [Cameroun, Suisse] ; Louis Maes [Belgique] ; Kurt Hostettmann [Suisse]Source :
- Phytotherapy Research [ 0951-418X ] ; 2010-11.
Abstract
The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.
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DOI: 10.1002/ptr.3192
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Chevalier (Ebenaceae)</title><author><name sortKey="Tangmouo, Jean Gustave" sort="Tangmouo, Jean Gustave" uniqKey="Tangmouo J" first="Jean Gustave" last="Tangmouo">Jean Gustave Tangmouo</name><affiliation wicri:level="1"><mods:affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</mods:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Organic Chemistry, University of Yaoundé I, P.O. 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Box 46 Maroua, Cameroon</mods:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 46 Maroua</wicri:regionArea></affiliation></author><author><name sortKey="Komguem, Justin" sort="Komguem, Justin" uniqKey="Komguem J" first="Justin" last="Komguem">Justin Komguem</name><affiliation wicri:level="1"><mods:affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</mods:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé</wicri:regionArea></affiliation></author><author><name sortKey="Messi, Bernadette Biloa" sort="Messi, Bernadette Biloa" uniqKey="Messi B" first="Bernadette Biloa" last="Messi">Bernadette Biloa Messi</name><affiliation wicri:level="1"><mods:affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</mods:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4</wicri:regionArea></affiliation></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><affiliation wicri:level="1"><mods:affiliation>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Hostettmann, Kurt" sort="Hostettmann, Kurt" uniqKey="Hostettmann K" first="Kurt" last="Hostettmann">Kurt Hostettmann</name><affiliation wicri:level="1"><mods:affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: kurt.hostettmann@unige.ch</mods:affiliation><country wicri:rule="url">Suisse</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Laboratoire de Pharmacognosie et Phytochimie, EPGL, Université de Genève, CH‐1211 Genève 4, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Correspondence address: Laboratoire de Pharmacognosie et Phytochimie, EPGL, Université de Genève, CH‐1211 Genève 4</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1676">1676</biblScope><biblScope unit="page" to="1679">1679</biblScope><biblScope unit="page-count">4</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-11">2010-11</date></imprint><idno type="ISSN">0951-418X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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