Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)
Identifieur interne : 001144 ( Istex/Corpus ); précédent : 001143; suivant : 001145Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)
Auteurs : Jean Gustave Tangmouo ; Raimana Ho ; An Matheeussen ; Alain Meli Lannang ; Justin Komguem ; Bernadette Biloa Messi ; Louis Maes ; Kurt HostettmannSource :
- Phytotherapy Research [ 0951-418X ] ; 2010-11.
Abstract
The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.
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DOI: 10.1002/ptr.3192
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Chevalier (Ebenaceae)</title><author><name sortKey="Tangmouo, Jean Gustave" sort="Tangmouo, Jean Gustave" uniqKey="Tangmouo J" first="Jean Gustave" last="Tangmouo">Jean Gustave Tangmouo</name><affiliation><mods:affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Ho, Raimana" sort="Ho, Raimana" uniqKey="Ho R" first="Raimana" last="Ho">Raimana Ho</name><affiliation><mods:affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Matheeussen, An" sort="Matheeussen, An" uniqKey="Matheeussen A" first="An" last="Matheeussen">An Matheeussen</name><affiliation><mods:affiliation>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Lannang, Alain Meli" sort="Lannang, Alain Meli" uniqKey="Lannang A" first="Alain Meli" last="Lannang">Alain Meli Lannang</name><affiliation><mods:affiliation>Department of Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 46 Maroua, Cameroon</mods:affiliation></affiliation></author><author><name sortKey="Komguem, Justin" sort="Komguem, Justin" uniqKey="Komguem J" first="Justin" last="Komguem">Justin Komguem</name><affiliation><mods:affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</mods:affiliation></affiliation></author><author><name sortKey="Messi, Bernadette Biloa" sort="Messi, Bernadette Biloa" uniqKey="Messi B" first="Bernadette Biloa" last="Messi">Bernadette Biloa Messi</name><affiliation><mods:affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><affiliation><mods:affiliation>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Hostettmann, Kurt" sort="Hostettmann, Kurt" uniqKey="Hostettmann K" first="Kurt" last="Hostettmann">Kurt Hostettmann</name><affiliation><mods:affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: kurt.hostettmann@unige.ch</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Laboratoire de Pharmacognosie et Phytochimie, EPGL, Université de Genève, CH‐1211 Genève 4, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1676">1676</biblScope><biblScope unit="page" to="1679">1679</biblScope><biblScope unit="page-count">4</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-11">2010-11</date></imprint><idno type="ISSN">0951-418X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>diospyros</json:string><json:string>antimalarial</json:string><json:string>cytotoxicity</json:string><json:string>dsm1</json:string><json:string>antimalarial activity</json:string><json:string>norbergenin</json:string><json:string>dsm4</json:string><json:string>falciparum</json:string><json:string>cameroon</json:string><json:string>tangmouo</json:string><json:string>methanol</json:string><json:string>ebenaceae</json:string><json:string>norbergenin derivative</json:string><json:string>john wiley son</json:string><json:string>copyright</json:string><json:string>dsm2</json:string><json:string>hmbc</json:string><json:string>dsm3</json:string><json:string>derivative</json:string><json:string>likhitwitayawuid</json:string><json:string>bergenin</json:string><json:string>phytother</json:string><json:string>cell growth</json:string><json:string>parasite</json:string><json:string>assay</json:string><json:string>chemical constituent</json:string><json:string>reference drug</json:string><json:string>human diploid embryonic lung fibroblast cell</json:string><json:string>diospyros extract</json:string><json:string>compound stock solution</json:string><json:string>microtiter plate</json:string><json:string>watery compound dilution</json:string><json:string>methyl derivative</json:string><json:string>control well</json:string><json:string>genu diospyros</json:string><json:string>moderate cytotoxicity</json:string><json:string>present study</json:string><json:string>diospyros quaesita</json:string><json:string>diospyros montana</json:string><json:string>cameroon national herbarium</json:string><json:string>chevalier</json:string></teeft></keywords><author><json:item><name>Jean Gustave Tangmouo</name><affiliations><json:string>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</json:string><json:string>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</json:string></affiliations></json:item><json:item><name>Raimana Ho</name><affiliations><json:string>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</json:string></affiliations></json:item><json:item><name>An Matheeussen</name><affiliations><json:string>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Alain Meli Lannang</name><affiliations><json:string>Department of Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 46 Maroua, Cameroon</json:string></affiliations></json:item><json:item><name>Justin Komguem</name><affiliations><json:string>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</json:string></affiliations></json:item><json:item><name>Bernadette Biloa Messi</name><affiliations><json:string>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</json:string><json:string>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</json:string></affiliations></json:item><json:item><name>Louis Maes</name><affiliations><json:string>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Kurt Hostettmann</name><affiliations><json:string>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</json:string><json:string>E-mail: kurt.hostettmann@unige.ch</json:string><json:string>Correspondence address: Laboratoire de Pharmacognosie et Phytochimie, EPGL, Université de Genève, CH‐1211 Genève 4, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Diospyros sanza‐minika</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Ebenaceae</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>norbergenin derivatives</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>in vitro</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>antimalarial</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cytotoxicity</value></json:item></subject><articleId><json:string>PTR3192</json:string></articleId><arkIstex>ark:/67375/WNG-52CL4D04-D</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>5.869</score><pdfWordCount>2225</pdfWordCount><pdfCharCount>15217</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>595.276 x 841.89 pts (A4)</pdfPageSize><pdfWordsPerPage>556</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>137</abstractWordCount><abstractCharCount>971</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. 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Chevalier (Ebenaceae)</title><title level="a" type="short" xml:lang="en">ANTIMALARIAL ACTIVITY OF STEM BARK OF DIOSPYROS SANZA‐MINIKA A. CHEVALIER</title><author xml:id="author-0000"><persName><forename type="first">Jean Gustave</forename><surname>Tangmouo</surname></persName><affiliation><orgName type="division">Department of Organic Chemistry</orgName><orgName type="institution">University of Yaoundé I</orgName><address><addrLine>P.O. Box 812 Yaoundé</addrLine><addrLine>Cameroon</addrLine><country key="CM" xml:lang="en">CAMEROON</country></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Pharmacognosy and Phytochemistry</orgName><orgName type="department">School of Pharmaceutical Sciences</orgName><orgName type="institution">University of Geneva</orgName><orgName type="institution">University of Lausanne</orgName><address><addrLine>Quai Ernest‐Ansermet 30</addrLine><addrLine>CH‐1211 Geneva 4, Switzerland</addrLine><country key="CH" xml:lang="en">SWITZERLAND</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Raimana</forename><surname>Ho</surname></persName><affiliation><orgName type="laboratory">Laboratory of Pharmacognosy and Phytochemistry</orgName><orgName type="department">School of Pharmaceutical Sciences</orgName><orgName type="institution">University of Geneva</orgName><orgName type="institution">University of Lausanne</orgName><address><addrLine>Quai Ernest‐Ansermet 30</addrLine><addrLine>CH‐1211 Geneva 4, Switzerland</addrLine><country key="CH" xml:lang="en">SWITZERLAND</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">An</forename><surname>Matheeussen</surname></persName><affiliation><orgName type="laboratory">Laboratory of Microbiology</orgName><orgName type="department">Parasitology</orgName><address><addrLine>and Hygiene</addrLine><addrLine>University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</addrLine><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Alain Meli</forename><surname>Lannang</surname></persName><affiliation><orgName type="division">Department of Chemistry</orgName><address><addrLine>Higher Teachers' Training College</addrLine><addrLine>University of Maroua, P.O. Box 46 Maroua, Cameroon</addrLine><country key="CM" xml:lang="en">CAMEROON</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Justin</forename><surname>Komguem</surname></persName><affiliation><orgName type="division">Department of Organic Chemistry</orgName><orgName type="institution">University of Yaoundé I</orgName><address><addrLine>P.O. Box 812 Yaoundé</addrLine><addrLine>Cameroon</addrLine><country key="CM" xml:lang="en">CAMEROON</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Bernadette Biloa</forename><surname>Messi</surname></persName><affiliation><orgName type="division">Department of Organic Chemistry</orgName><orgName type="institution">University of Yaoundé I</orgName><address><addrLine>P.O. Box 812 Yaoundé</addrLine><addrLine>Cameroon</addrLine><country key="CM" xml:lang="en">CAMEROON</country></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Pharmacognosy and Phytochemistry</orgName><orgName type="department">School of Pharmaceutical Sciences</orgName><orgName type="institution">University of Geneva</orgName><orgName type="institution">University of Lausanne</orgName><address><addrLine>Quai Ernest‐Ansermet 30</addrLine><addrLine>CH‐1211 Geneva 4, Switzerland</addrLine><country key="CH" xml:lang="en">SWITZERLAND</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Louis</forename><surname>Maes</surname></persName><affiliation><orgName type="laboratory">Laboratory of Microbiology</orgName><orgName type="department">Parasitology</orgName><address><addrLine>and Hygiene</addrLine><addrLine>University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</addrLine><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0007" role="corresp"><persName><forename type="first">Kurt</forename><surname>Hostettmann</surname></persName><email>kurt.hostettmann@unige.ch</email><affiliation><orgName type="laboratory">Laboratory of Pharmacognosy and Phytochemistry</orgName><orgName type="department">School of Pharmaceutical Sciences</orgName><orgName type="institution">University of Geneva</orgName><orgName type="institution">University of Lausanne</orgName><address><addrLine>Quai Ernest‐Ansermet 30</addrLine><addrLine>CH‐1211 Geneva 4, Switzerland</addrLine><country key="CH" xml:lang="en">SWITZERLAND</country></address></affiliation></author><idno type="istex">B747D3A0175ACC2032904783D144162550E52739</idno><idno type="ark">ark:/67375/WNG-52CL4D04-D</idno><idno type="DOI">10.1002/ptr.3192</idno><idno type="unit">PTR3192</idno><idno type="toTypesetVersion">file:PTR.PTR3192.pdf</idno></analytic><monogr><title level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="pISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><idno type="book-DOI">10.1002/(ISSN)1099-1573</idno><idno type="book-part-DOI">10.1002/ptr.v24:11</idno><idno type="product">PTR</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1676">1676</biblScope><biblScope unit="page" to="1679">1679</biblScope><biblScope unit="page-count">4</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The methanol extract from the stem bark of <hi rend="italic">Diospyros sanza‐minika</hi> as well as five norbergenin derivatives isolated from this crude extract were evaluated for their <hi rend="italic">in vitro</hi> activity against <hi rend="italic">Plasmodium falciparum</hi> K1 and cytotoxicity on MRC‐5 cells. 4‐<hi rend="italic">O</hi>‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC<hi rend="subscript">50</hi> 0.6 μg/mL; CC<hi rend="subscript">50</hi> 24.7 μg/mL), followed by 4‐<hi rend="italic">O</hi>‐galloylnorbergenin (IC<hi rend="subscript">50</hi> 3.9 μg/mL; CC<hi rend="subscript">50</hi> > 64 μg/mL) and 11‐<hi rend="italic">O</hi>‐<hi rend="italic">p</hi>‐hydroxy‐benzoyl‐norbergenin (IC<hi rend="subscript">50</hi> 4.9 μg/mL; CC<hi rend="subscript">50</hi> > 64 μg/mL). Norbergenin and 4‐<hi rend="italic">O</hi>‐syringoylnorbergenin were inactive (IC<hi rend="subscript">50</hi> > 32 μg/mL; CC<hi rend="subscript">50</hi> > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of <hi rend="italic">Diospyros sanza‐minika</hi> is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1"><hi rend="italic">Diospyros sanza‐minika</hi></term><term xml:id="kwd2">Ebenaceae</term><term xml:id="kwd3">norbergenin derivatives</term><term xml:id="kwd4"><hi rend="italic">in vitro</hi></term><term xml:id="kwd5">antimalarial</term><term xml:id="kwd6">cytotoxicity</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords><keywords rend="tocHeading1"><term>Research Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-52CL4D04-D/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-1573</doi><issn type="print">0951-418X</issn><issn type="electronic">1099-1573</issn><idGroup><id type="product" value="PTR"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="PHYTOTHERAPY RESEARCH">Phytotherapy Research</title><title type="short">Phytother. Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="110"><doi origin="wiley" registered="yes">10.1002/ptr.v24:11</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">11</numbering></numberingGroup><coverDate startDate="2010-11">November 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="160" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ptr.3192</doi><idGroup><id type="unit" value="PTR3192"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2010 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2009-11-30"></event><event type="manuscriptRevised" date="2010-03-18"></event><event type="manuscriptAccepted" date="2010-03-18"></event><event type="firstOnline" date="2010-10-28"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-06-07"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.25 mode:FullText" date="2010-10-28"></event><event type="publishedOnlineFinalForm" date="2010-10-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">1676</numbering><numbering type="pageLast">1679</numbering></numberingGroup><correspondenceTo>Laboratoire de Pharmacognosie et Phytochimie, EPGL, Université de Genève, CH‐1211 Genève 4, Switzerland</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PTR.PTR3192.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="13"></count></countGroup><titleGroup><title type="main" xml:lang="en">Antimalarial activity of extract and norbergenin derivatives from the stem bark of <i>Diospyros sanza‐minika</i> A. Chevalier (Ebenaceae)</title><title type="short" xml:lang="en">ANTIMALARIAL ACTIVITY OF STEM BARK OF <fi>DIOSPYROS SANZA‐MINIKA</fi> A. CHEVALIER</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Jean Gustave</givenNames><familyName>Tangmouo</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Raimana</givenNames><familyName>Ho</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>An</givenNames><familyName>Matheeussen</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Alain Meli</givenNames><familyName>Lannang</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Justin</givenNames><familyName>Komguem</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Bernadette Biloa</givenNames><familyName>Messi</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Louis</givenNames><familyName>Maes</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Kurt</givenNames><familyName>Hostettmann</familyName></personName><contactDetails><email>kurt.hostettmann@unige.ch</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CM" type="organization"><unparsedAffiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CH" type="organization"><unparsedAffiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="BE" type="organization"><unparsedAffiliation>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CM" type="organization"><unparsedAffiliation>Department of Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 46 Maroua, Cameroon</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1"><i>Diospyros sanza‐minika</i></keyword><keyword xml:id="kwd2">Ebenaceae</keyword><keyword xml:id="kwd3">norbergenin derivatives</keyword><keyword xml:id="kwd4"><i>in vitro</i></keyword><keyword xml:id="kwd5">antimalarial</keyword><keyword xml:id="kwd6">cytotoxicity</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The methanol extract from the stem bark of <i>Diospyros sanza‐minika</i> as well as five norbergenin derivatives isolated from this crude extract were evaluated for their <i>in vitro</i> activity against <i>Plasmodium falciparum</i> K1 and cytotoxicity on MRC‐5 cells. 4‐<i>O</i>‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC<sub>50</sub> 0.6 μg/mL; CC<sub>50</sub> 24.7 μg/mL), followed by 4‐<i>O</i>‐galloylnorbergenin (IC<sub>50</sub> 3.9 μg/mL; CC<sub>50</sub> > 64 μg/mL) and 11‐<i>O</i>‐<i>p</i>‐hydroxy‐benzoyl‐norbergenin (IC<sub>50</sub> 4.9 μg/mL; CC<sub>50</sub> > 64 μg/mL). Norbergenin and 4‐<i>O</i>‐syringoylnorbergenin were inactive (IC<sub>50</sub> > 32 μg/mL; CC<sub>50</sub> > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of <i>Diospyros sanza‐minika</i> is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>ANTIMALARIAL ACTIVITY OF STEM BARK OF DIOSPYROS SANZA‐MINIKA A. CHEVALIER</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)</title></titleInfo><name type="personal"><namePart type="given">Jean Gustave</namePart><namePart type="family">Tangmouo</namePart><affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</affiliation><affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raimana</namePart><namePart type="family">Ho</namePart><affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">An</namePart><namePart type="family">Matheeussen</namePart><affiliation>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain Meli</namePart><namePart type="family">Lannang</namePart><affiliation>Department of Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 46 Maroua, Cameroon</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Justin</namePart><namePart type="family">Komguem</namePart><affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernadette Biloa</namePart><namePart type="family">Messi</namePart><affiliation>Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon</affiliation><affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Louis</namePart><namePart type="family">Maes</namePart><affiliation>Laboratory of Microbiology, Parasitology, and Hygiene, University of Antwerp, Groenenborgerlaan, 171, 2020, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kurt</namePart><namePart type="family">Hostettmann</namePart><affiliation>Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4, Switzerland</affiliation><affiliation>E-mail: kurt.hostettmann@unige.ch</affiliation><affiliation>Correspondence address: Laboratoire de Pharmacognosie et Phytochimie, EPGL, Université de Genève, CH‐1211 Genève 4, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-11</dateIssued><dateCaptured encoding="w3cdtf">2009-11-30</dateCaptured><dateValid encoding="w3cdtf">2010-03-18</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">13</extent></physicalDescription><abstract lang="en">The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><subject lang="en"><genre>keywords</genre><topic>Diospyros sanza‐minika</topic><topic>Ebenaceae</topic><topic>norbergenin derivatives</topic><topic>in vitro</topic><topic>antimalarial</topic><topic>cytotoxicity</topic></subject><relatedItem type="host"><titleInfo><title>Phytotherapy Research</title></titleInfo><titleInfo type="abbreviated"><title>Phytother. Res.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic><topic>Research Articles</topic></subject><identifier type="ISSN">0951-418X</identifier><identifier type="eISSN">1099-1573</identifier><identifier type="DOI">10.1002/(ISSN)1099-1573</identifier><identifier type="PublisherID">PTR</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1676</start><end>1679</end><total>4</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Radical scavenging activity and phenolic compounds in persimmon (Diospyros kaki L. cv. Mopan)</title></titleInfo><name type="personal"><namePart type="given">XN</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Fan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Yue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XR</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LT.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen XN, Fan JF, Yue X, Wu XR, Li LT. 2008. Radical scavenging activity and phenolic compounds in persimmon (Diospyros kaki L. cv. Mopan). J Food Sci 73: C24–C28.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>C24</start><end>C28</end></extent></part><relatedItem type="host"><titleInfo><title>J Food Sci</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>C24</start><end>C28</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Investigation of Indian Diospyros species for antiplasmodial properties</title></titleInfo><name type="personal"><namePart type="given">VSS</namePart><namePart type="family">Kantamreddi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW.</namePart><namePart type="family">Wright</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kantamreddi VSS, Wright CW. 2008. Investigation of Indian Diospyros species for antiplasmodial properties. Evid Based Complement Alternat Med 5: 187–190.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>187</start><end>190</end></extent></part><relatedItem type="host"><titleInfo><title>Evid Based Complement Alternat Med</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>187</start><end>190</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Letouzey R, White F. 1970. Flore du Cameroun, Ebénacées et Ericacées. Muséum Nationale d'Histoire Naturelle: Paris, 143–147.</title></titleInfo><note type="citation/reference">Letouzey R, White F. 1970. Flore du Cameroun, Ebénacées et Ericacées. Muséum Nationale d'Histoire Naturelle: Paris, 143–147.</note><name type="personal"><namePart type="given">R</namePart><namePart type="family">Letouzey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Muséum Nationale d'Histoire Naturelle</publisher><place><placeTerm type="text">Paris</placeTerm></place></originInfo><part><date>1970</date><extent unit="pages"><start>143</start><end>147</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Likhitwitayawuid</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Dej‐adisai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Jongbunprasert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Krungkrai</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Likhitwitayawuid K, Dej‐adisai S, Jongbunprasert V, Krungkrai J. 1999. Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis. Planta Med 65: 754–756.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>754</start><end>756</end></extent></part><relatedItem type="host"><titleInfo><title>Planta Med</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>754</start><end>756</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Study of antimalarial activity of chemical constituents from Diospyros quaesita</title></titleInfo><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Musoke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GT</namePart><namePart type="family">Tan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ma CY, Musoke SF, Tan GT et al. 2008. Study of antimalarial activity of chemical constituents from Diospyros quaesita. Chem Biodivers 5: 2442–2448.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>2442</start><end>2448</end></extent></part><relatedItem type="host"><titleInfo><title>Chem Biodivers</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>2442</start><end>2448</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drugs sensitivity</title></titleInfo><name type="personal"><namePart type="given">MT</namePart><namePart type="family">Makler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Ries</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Makler MT, Ries JM, Williams JA et al. 1993. Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drugs sensitivity. Am J Trop Med Hyg 48: 739–741.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>739</start><end>741</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>739</start><end>741</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>11‐(E)‐p‐coumaric acid ester of bergenin from Peltophorum africanum</title></titleInfo><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Mebe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Makuhunga</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mebe PP, Makuhunga P. 1992. 11‐(E)‐p‐coumaric acid ester of bergenin from Peltophorum africanum. Phytochemistry 31: 3286–3287.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>3286</start><end>3287</end></extent></part><relatedItem type="host"><titleInfo><title>Phytochemistry</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>3286</start><end>3287</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Ebenaceae extractives. Part IV. Diosindigo A, a blue pigment from several diospyros species</title></titleInfo><name type="personal"><namePart type="given">OC</namePart><namePart type="family">Musgrave</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Skoyles</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Musgrave OC, Skoyles D. 1974. Ebenaceae extractives. Part IV. Diosindigo A, a blue pigment from several diospyros species. J C S Perkin I: 1128–1131.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>I</number></detail><extent unit="pages"><start>1128</start><end>1131</end></extent></part><relatedItem type="host"><titleInfo><title>J C S Perkin</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>I</number></detail><extent unit="pages"><start>1128</start><end>1131</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Chemical constituents and preliminary antimalarial activity of Humiria balsamifera</title></titleInfo><name type="personal"><namePart type="given">TBCD</namePart><namePart type="family">Silva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VL</namePart><namePart type="family">Alves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LVH</namePart><namePart type="family">Mendonça</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Silva TBCD, Alves VL, Mendonça LVH et al. 2004. Chemical constituents and preliminary antimalarial activity of Humiria balsamifera. Pharm Biol 42: 94–97.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>94</start><end>97</end></extent></part><relatedItem type="host"><titleInfo><title>Pharm Biol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>94</start><end>97</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Sofowara EA. 1996. Plantes Médicinales et Médecine Tropicale d'Afrique, 2nd edn, vol. 1. Karthala, Paris, France, 1–256.</title></titleInfo><note type="citation/reference">Sofowara EA. 1996. Plantes Médicinales et Médecine Tropicale d'Afrique, 2nd edn, vol. 1. Karthala, Paris, France, 1–256.</note><name type="personal"><namePart type="given">EA.</namePart><namePart type="family">Sofowara</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Karthala</publisher><place><placeTerm type="text">Paris, France</placeTerm></place></originInfo><part><date>1996</date><extent unit="pages"><start>1</start><end>256</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Crassiflorone, a new naphthoquinone from Diospyros crassiflora (Hien)</title></titleInfo><name type="personal"><namePart type="given">JG</namePart><namePart type="family">Tangmouo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Meli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Komguem</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tangmouo JG, Meli AL, Komguem J et al. 2006. Crassiflorone, a new naphthoquinone from Diospyros crassiflora (Hien). Tetrahedron Lett 47: 3067–3070.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>3067</start><end>3070</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron Lett</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>3067</start><end>3070</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Norbergenin derivatives from the stem bark of Diospyros sanza‐minika (Ebenaceae) and their radical scavenging activity</title></titleInfo><name type="personal"><namePart type="given">JG</namePart><namePart type="family">Tangmouo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ho</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Meli</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tangmouo JG, Ho R, Meli AL et al. 2009. Norbergenin derivatives from the stem bark of Diospyros sanza‐minika (Ebenaceae) and their radical scavenging activity. Phytochem Lett 2: 192–195.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>192</start><end>195</end></extent></part><relatedItem type="host"><titleInfo><title>Phytochem Lett</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>192</start><end>195</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Human malaria parasites in continuous culture</title></titleInfo><name type="personal"><namePart type="given">W</namePart><namePart type="family">Trager</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB.</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Trager W, Jensen JB. 1976. Human malaria parasites in continuous culture. Science 193: 673–675.</note><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>193</number></detail><extent unit="pages"><start>673</start><end>675</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>193</number></detail><extent unit="pages"><start>673</start><end>675</end></extent></part></relatedItem></relatedItem><identifier type="istex">B747D3A0175ACC2032904783D144162550E52739</identifier><identifier type="ark">ark:/67375/WNG-52CL4D04-D</identifier><identifier type="DOI">10.1002/ptr.3192</identifier><identifier type="ArticleID">PTR3192</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-52CL4D04-D/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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