ChloroquineV1, Istex, Curation, bibRecord, 000B59

Neutral proteinase inhibitors and antimetastatic effects in mice

Identifieur interne : 000B59 ( Istex/Curation ); précédent : 000B58; suivant : 000B60

Neutral proteinase inhibitors and antimetastatic effects in mice

Auteurs : T. Giraldi [Italie] ; G. Sava [Italie] ; M. Kopitar [Slovénie] ; J. Brzin [Slovénie] ; V. Turk [Slovénie]

Source :

European Journal of Cancer (1965) [ 0014-2964 ] ; 1980.

RBID : ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6

English descriptors

Teeft :
- Acta biol, Antimetastatic, Antimetastatic effects, Aspirin, Aurintricarboxylic acid, Biochem, Carcinoma, Cathepsin, Chloroquine, Collagenase, Collagenolytic, Collagenolytic activity, Giraldi, Indomethacin, Inhibitor, Kopitar, Large metastases, Lewis lung carcinoma, Metastasis, Metastasis weight, Neutral proteinase inhibitors, Neutral proteinases, Phenylbutazone, Primary tumor growth, Proteinase, Proteinase inhibitors, Same time, Significant reduction, Snpis, Tumor growth, Tumor implantation, Tumor weight.

Abstract

Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.

Url:

https://api.istex.fr/ark:/67375/6H6-CD5DW622-J/fulltext.pdf

DOI: 10.1016/0014-2964(80)90224-8

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B59

Links to Exploration step

ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Neutral proteinase inhibitors and antimetastatic effects in mice</title>
<author><name sortKey="Giraldi, T" sort="Giraldi, T" uniqKey="Giraldi T" first="T." last="Giraldi">T. Giraldi</name>
<affiliation wicri:level="1"><mods:affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sava, G" sort="Sava, G" uniqKey="Sava G" first="G." last="Sava">G. Sava</name>
<affiliation wicri:level="1"><mods:affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kopitar, M" sort="Kopitar, M" uniqKey="Kopitar M" first="M." last="Kopitar">M. Kopitar</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brzin, J" sort="Brzin, J" uniqKey="Brzin J" first="J." last="Brzin">J. Brzin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turk, V" sort="Turk, V" uniqKey="Turk V" first="V." last="Turk">V. Turk</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6</idno>
<date when="1980" year="1980">1980</date>
<idno type="doi">10.1016/0014-2964(80)90224-8</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-CD5DW622-J/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B59</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B59</idno>
<idno type="wicri:Area/Istex/Curation">000B59</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Neutral proteinase inhibitors and antimetastatic effects in mice</title>
<author><name sortKey="Giraldi, T" sort="Giraldi, T" uniqKey="Giraldi T" first="T." last="Giraldi">T. Giraldi</name>
<affiliation wicri:level="1"><mods:affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sava, G" sort="Sava, G" uniqKey="Sava G" first="G." last="Sava">G. Sava</name>
<affiliation wicri:level="1"><mods:affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kopitar, M" sort="Kopitar, M" uniqKey="Kopitar M" first="M." last="Kopitar">M. Kopitar</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brzin, J" sort="Brzin, J" uniqKey="Brzin J" first="J." last="Brzin">J. Brzin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turk, V" sort="Turk, V" uniqKey="Turk V" first="V." last="Turk">V. Turk</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Cancer (1965)</title>
<title level="j" type="abbrev">EJCOLD</title>
<idno type="ISSN">0014-2964</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1980">1980</date>
<biblScope unit="volume">16</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="449">449</biblScope>
<biblScope unit="page" to="454">454</biblScope>
</imprint>
<idno type="ISSN">0014-2964</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0014-2964</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta biol</term>
<term>Antimetastatic</term>
<term>Antimetastatic effects</term>
<term>Aspirin</term>
<term>Aurintricarboxylic acid</term>
<term>Biochem</term>
<term>Carcinoma</term>
<term>Cathepsin</term>
<term>Chloroquine</term>
<term>Collagenase</term>
<term>Collagenolytic</term>
<term>Collagenolytic activity</term>
<term>Giraldi</term>
<term>Indomethacin</term>
<term>Inhibitor</term>
<term>Kopitar</term>
<term>Large metastases</term>
<term>Lewis lung carcinoma</term>
<term>Metastasis</term>
<term>Metastasis weight</term>
<term>Neutral proteinase inhibitors</term>
<term>Neutral proteinases</term>
<term>Phenylbutazone</term>
<term>Primary tumor growth</term>
<term>Proteinase</term>
<term>Proteinase inhibitors</term>
<term>Same time</term>
<term>Significant reduction</term>
<term>Snpis</term>
<term>Tumor growth</term>
<term>Tumor implantation</term>
<term>Tumor weight</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B59 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000B59 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Istex
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6
   |texte=   Neutral proteinase inhibitors and antimetastatic effects in mice
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Neutral proteinase inhibitors and antimetastatic effects in mice

Neutral proteinase inhibitors and antimetastatic effects in mice

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri