Neutral proteinase inhibitors and antimetastatic effects in mice
Identifieur interne : 000B59 ( Istex/Corpus ); précédent : 000B58; suivant : 000B60Neutral proteinase inhibitors and antimetastatic effects in mice
Auteurs : T. Giraldi ; G. Sava ; M. Kopitar ; J. Brzin ; V. TurkSource :
- European Journal of Cancer (1965) [ 0014-2964 ] ; 1980.
English descriptors
- Teeft :
- Acta biol, Antimetastatic, Antimetastatic effects, Aspirin, Aurintricarboxylic acid, Biochem, Carcinoma, Cathepsin, Chloroquine, Collagenase, Collagenolytic, Collagenolytic activity, Giraldi, Indomethacin, Inhibitor, Kopitar, Large metastases, Lewis lung carcinoma, Metastasis, Metastasis weight, Neutral proteinase inhibitors, Neutral proteinases, Phenylbutazone, Primary tumor growth, Proteinase, Proteinase inhibitors, Same time, Significant reduction, Snpis, Tumor growth, Tumor implantation, Tumor weight.
Abstract
Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.
Url:
DOI: 10.1016/0014-2964(80)90224-8
Links to Exploration step
ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6Le document en format XML
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Giraldi</name><affiliation><mods:affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sava, G" sort="Sava, G" uniqKey="Sava G" first="G." last="Sava">G. Sava</name><affiliation><mods:affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</mods:affiliation></affiliation></author><author><name sortKey="Kopitar, M" sort="Kopitar, M" uniqKey="Kopitar M" first="M." last="Kopitar">M. Kopitar</name><affiliation><mods:affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</mods:affiliation></affiliation></author><author><name sortKey="Brzin, J" sort="Brzin, J" uniqKey="Brzin J" first="J." last="Brzin">J. Brzin</name><affiliation><mods:affiliation>Department of Biochemistry, J. 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The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. 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Giraldi</name><affiliations><json:string>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</json:string></affiliations></json:item><json:item><name>G. Sava</name><affiliations><json:string>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</json:string></affiliations></json:item><json:item><name>M. Kopitar</name><affiliations><json:string>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</json:string></affiliations></json:item><json:item><name>J. Brzin</name><affiliations><json:string>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</json:string></affiliations></json:item><json:item><name>V. Turk</name><affiliations><json:string>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ATA : aurintricarboxylic acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SNPI : spleen neutral proteinase inhibitor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LNPI : leucocyte neutral proteinase inhibitor</value></json:item></subject><arkIstex>ark:/67375/6H6-CD5DW622-J</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. 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F7F030Y, and by Grants from Italian Ministry of Education (MPI) and from the University of Trieste.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Neutral proteinase inhibitors and antimetastatic effects in mice</title><author xml:id="author-0000"><persName><forename type="first">T.</forename><surname>Giraldi</surname></persName><affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</affiliation></author><author xml:id="author-0001"><persName><forename type="first">G.</forename><surname>Sava</surname></persName><affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M.</forename><surname>Kopitar</surname></persName><affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</affiliation></author><author xml:id="author-0003"><persName><forename type="first">J.</forename><surname>Brzin</surname></persName><affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</affiliation></author><author xml:id="author-0004"><persName><forename type="first">V.</forename><surname>Turk</surname></persName><affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</affiliation></author><idno type="istex">E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6</idno><idno type="ark">ark:/67375/6H6-CD5DW622-J</idno><idno type="DOI">10.1016/0014-2964(80)90224-8</idno><idno type="PII">0014-2964(80)90224-8</idno></analytic><monogr><title level="j">European Journal of Cancer (1965)</title><title level="j" type="abbrev">EJCOLD</title><idno type="pISSN">0014-2964</idno><idno type="PII">S0014-2964(00)X0062-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="454">454</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1980</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>ATA</term><term>aurintricarboxylic acid</term></item><item><term>SNPI</term><term>spleen neutral proteinase inhibitor</term></item><item><term>LNPI</term><term>leucocyte neutral proteinase inhibitor</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1980">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-CD5DW622-J/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>EJCOLD</jid><aid>80902248</aid><ce:pii>0014-2964(80)90224-8</ce:pii><ce:doi>10.1016/0014-2964(80)90224-8</ce:doi><ce:copyright type="unknown" year="1980"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Supported by Grants from Research Council of Slovenia, in part by the NSF n. F7F030Y, and by Grants from Italian Ministry of Education (MPI) and from the University of Trieste.</ce:note-para></ce:article-footnote><ce:title>Neutral proteinase inhibitors and antimetastatic effects in mice</ce:title><ce:author-group><ce:author><ce:given-name>T.</ce:given-name><ce:surname>Giraldi</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>G.</ce:given-name><ce:surname>Sava</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Kopitar</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Brzin</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>V.</ce:given-name><ce:surname>Turk</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</ce:textfn></ce:affiliation></ce:author-group><ce:date-accepted day="1" month="8" year="1979"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>ATA</ce:text><ce:keyword><ce:text>aurintricarboxylic acid</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>SNPI</ce:text><ce:keyword><ce:text>spleen neutral proteinase inhibitor</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>LNPI</ce:text><ce:keyword><ce:text>leucocyte neutral proteinase inhibitor</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Neutral proteinase inhibitors and antimetastatic effects in mice</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Neutral proteinase inhibitors and antimetastatic effects in mice</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Giraldi</namePart><affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Sava</namePart><affiliation>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kopitar</namePart><affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Brzin</namePart><affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Turk</namePart><affiliation>Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Yugoslavia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1980</dateIssued><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.</abstract><note>Supported by Grants from Research Council of Slovenia, in part by the NSF n. F7F030Y, and by Grants from Italian Ministry of Education (MPI) and from the University of Trieste.</note><subject><genre>Abbreviations</genre><topic>ATA : aurintricarboxylic acid</topic><topic>SNPI : spleen neutral proteinase inhibitor</topic><topic>LNPI : leucocyte neutral proteinase inhibitor</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Cancer (1965)</title></titleInfo><titleInfo type="abbreviated"><title>EJCOLD</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1980</dateIssued></originInfo><identifier type="ISSN">0014-2964</identifier><identifier type="PII">S0014-2964(00)X0062-X</identifier><part><date>1980</date><detail type="volume"><number>16</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue-pages"><start>427</start><end>590</end></extent><extent unit="pages"><start>449</start><end>454</end></extent></part></relatedItem><identifier type="istex">E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6</identifier><identifier type="ark">ark:/67375/6H6-CD5DW622-J</identifier><identifier type="DOI">10.1016/0014-2964(80)90224-8</identifier><identifier type="PII">0014-2964(80)90224-8</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-CD5DW622-J/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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