Subcutaneous sarcoidosis—clinicopathological study of 10 cases
Identifieur interne : 002366 ( Istex/Corpus ); précédent : 002365; suivant : 002367Subcutaneous sarcoidosis—clinicopathological study of 10 cases
Auteurs : J. Marcoval ; J. Ma A ; A. Moreno ; J. PeyriSource :
- British Journal of Dermatology [ 0007-0963 ] ; 2005-10.
Abstract
Background Subcutaneous sarcoidosis is a specific cutaneous lesion of sarcoidosis that is rarely reported. Objective Our purpose was to analyse the clinicopathological features of 10 patients with subcutaneous sarcoidosis and its relationship with the systemic features of the disease. Patients and methods The patients with systemic sarcoidosis, diagnosed from 1974 to 2002 at a university hospital in Barcelona, Spain, who developed subcutaneous involvement, were included in the study. The diagnosis of systemic sarcoidosis was made according to conventional criteria. All the patients were monitored prospectively at the sarcoidosis clinic of the hospital. Skin biopsies were performed when granulomatous cutaneous involvement was suspected clinically. Results Granulomatous cutaneous involvement was demonstrated in 85 of 480 patients with systemic sarcoidosis. In 10 of these 85 patients subcutaneous sarcoidosis was diagnosed (11·8%). The lesions were most frequently located in the extremities, involving the forearms in nine patients. Indurated linear bands from the elbow to the hand were observed in five patients. In all of our patients the subcutaneous nodules appeared at the beginning of the disease. In six patients, the nodules remitted spontaneously in less than 2 years. In two cases foreign particles were detected under polarized light. Conclusions Subcutaneous sarcoidosis is a quite uniform clinicopathological entity usually appearing at the beginning of the disease. It usually heralds forms of sarcoidosis with nonsevere systemic involvement and is not associated with chronic fibrotic disease.
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DOI: 10.1111/j.1365-2133.2005.06815.x
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ISTEX:84FA235B9B5DBFBDFDBCBEAAF3C7091160D2ED7ELe document en format XML
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Marcoval</name><affiliation><mods:affiliation>Departments of Dermatology, Internal Medicine</mods:affiliation></affiliation></author><author><name sortKey="Ma A, J" sort="Ma A, J" uniqKey="Ma A J" first="J." last="Ma A">J. Ma A</name><affiliation><mods:affiliation>Departments of Dermatology, Internal Medicine</mods:affiliation></affiliation></author><author><name sortKey="Moreno, A" sort="Moreno, A" uniqKey="Moreno A" first="A." last="Moreno">A. Moreno</name><affiliation><mods:affiliation>Pathology, Hospital de Bellvitge, c/Feixa Llarga s/n, Hospitalet de Llobregat, University of Barcelona, 08907 Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Peyri, J" sort="Peyri, J" uniqKey="Peyri J" first="J." last="Peyri">J. Peyri</name><affiliation><mods:affiliation>Departments of Dermatology, Internal Medicine</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">British Journal of Dermatology</title><title level="j" type="alt">BRITISH JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><imprint><biblScope unit="vol">153</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="790">790</biblScope><biblScope unit="page" to="794">794</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Science Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-10">2005-10</date></imprint><idno type="ISSN">0007-0963</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Subcutaneous sarcoidosis is a specific cutaneous lesion of sarcoidosis that is rarely reported. Objective Our purpose was to analyse the clinicopathological features of 10 patients with subcutaneous sarcoidosis and its relationship with the systemic features of the disease. Patients and methods The patients with systemic sarcoidosis, diagnosed from 1974 to 2002 at a university hospital in Barcelona, Spain, who developed subcutaneous involvement, were included in the study. The diagnosis of systemic sarcoidosis was made according to conventional criteria. All the patients were monitored prospectively at the sarcoidosis clinic of the hospital. Skin biopsies were performed when granulomatous cutaneous involvement was suspected clinically. Results Granulomatous cutaneous involvement was demonstrated in 85 of 480 patients with systemic sarcoidosis. In 10 of these 85 patients subcutaneous sarcoidosis was diagnosed (11·8%). The lesions were most frequently located in the extremities, involving the forearms in nine patients. Indurated linear bands from the elbow to the hand were observed in five patients. In all of our patients the subcutaneous nodules appeared at the beginning of the disease. In six patients, the nodules remitted spontaneously in less than 2 years. In two cases foreign particles were detected under polarized light. Conclusions Subcutaneous sarcoidosis is a quite uniform clinicopathological entity usually appearing at the beginning of the disease. It usually heralds forms of sarcoidosis with nonsevere systemic involvement and is not associated with chronic fibrotic disease.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>sarcoidosis</json:string><json:string>subcutaneous</json:string><json:string>subcutaneous sarcoidosis</json:string><json:string>nodule</json:string><json:string>cutaneous</json:string><json:string>granulomatous</json:string><json:string>systemic sarcoidosis</json:string><json:string>lesion</json:string><json:string>granuloma</json:string><json:string>subcutaneous nodule</json:string><json:string>dermatol</json:string><json:string>marcoval</json:string><json:string>dermatology</json:string><json:string>corticosteroid</json:string><json:string>constitutional symptom</json:string><json:string>dermatologist</json:string><json:string>nodosum</json:string><json:string>erythema</json:string><json:string>foreign body</json:string><json:string>arch dermatol</json:string><json:string>linear band</json:string><json:string>erythema nodosum</json:string><json:string>british association</json:string><json:string>dermatologist british journal</json:string><json:string>indurated</json:string><json:string>clinicopathological</json:string><json:string>sarcoid</json:string><json:string>barcelona</json:string><json:string>systemic</json:string><json:string>indurated linear band</json:string><json:string>subcutaneous lesion</json:string><json:string>granulomatous cutaneous involvement</json:string><json:string>noncaseating granuloma</json:string><json:string>systemic involvement</json:string><json:string>specific cutaneous lesion</json:string><json:string>present study</json:string><json:string>systemic feature</json:string></teeft></keywords><author><json:item><name>J. Marcoval</name><affiliations><json:string>Departments of Dermatology, Internal Medicine</json:string></affiliations></json:item><json:item><name>J. Maña</name><affiliations><json:string>Departments of Dermatology, Internal Medicine</json:string></affiliations></json:item><json:item><name>A. Moreno</name><affiliations><json:string>Pathology, Hospital de Bellvitge, c/Feixa Llarga s/n, Hospitalet de Llobregat, University of Barcelona, 08907 Barcelona, Spain</json:string></affiliations></json:item><json:item><name>J. Peyri</name><affiliations><json:string>Departments of Dermatology, Internal Medicine</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>sarcoidosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>skin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subcutaneous sarcoidosis</value></json:item></subject><articleId><json:string>BJD6815</json:string></articleId><arkIstex>ark:/67375/WNG-P9N0TSXN-V</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background Subcutaneous sarcoidosis is a specific cutaneous lesion of sarcoidosis that is rarely reported. Objective Our purpose was to analyse the clinicopathological features of 10 patients with subcutaneous sarcoidosis and its relationship with the systemic features of the disease. Patients and methods The patients with systemic sarcoidosis, diagnosed from 1974 to 2002 at a university hospital in Barcelona, Spain, who developed subcutaneous involvement, were included in the study. The diagnosis of systemic sarcoidosis was made according to conventional criteria. All the patients were monitored prospectively at the sarcoidosis clinic of the hospital. Skin biopsies were performed when granulomatous cutaneous involvement was suspected clinically. Results Granulomatous cutaneous involvement was demonstrated in 85 of 480 patients with systemic sarcoidosis. In 10 of these 85 patients subcutaneous sarcoidosis was diagnosed (11·8%). The lesions were most frequently located in the extremities, involving the forearms in nine patients. Indurated linear bands from the elbow to the hand were observed in five patients. In all of our patients the subcutaneous nodules appeared at the beginning of the disease. In six patients, the nodules remitted spontaneously in less than 2 years. In two cases foreign particles were detected under polarized light. Conclusions Subcutaneous sarcoidosis is a quite uniform clinicopathological entity usually appearing at the beginning of the disease. 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E‐mail: <email>jmarcoval@csub.scs.es</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BJD.BJD6815.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 22 February 2005</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="16"></count><count type="wordTotal" number="2079"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Subcutaneous sarcoidosis—clinicopathological study of 10 cases</title><title type="shortAuthors">J. Marcoval <i>et al.</i></title><title type="short">Subcutaneous sarcoidosis</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>J.</givenNames><familyName>Marcoval</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>J.</givenNames><familyName>Maña</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>A.</givenNames><familyName>Moreno</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>J.</givenNames><familyName>Peyri</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Departments of Dermatology, Internal Medicine</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="ES"><unparsedAffiliation>Pathology, Hospital de Bellvitge, c/Feixa Llarga s/n, Hospitalet de Llobregat, University of Barcelona, 08907 Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">sarcoidosis</keyword><keyword xml:id="k2">skin</keyword><keyword xml:id="k3">subcutaneous sarcoidosis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p><b>Background </b> Subcutaneous sarcoidosis is a specific cutaneous lesion of sarcoidosis that is rarely reported.</p><p><b>Objective </b> Our purpose was to analyse the clinicopathological features of 10 patients with subcutaneous sarcoidosis and its relationship with the systemic features of the disease.</p><p><b>Patients and methods </b> The patients with systemic sarcoidosis, diagnosed from 1974 to 2002 at a university hospital in Barcelona, Spain, who developed subcutaneous involvement, were included in the study. The diagnosis of systemic sarcoidosis was made according to conventional criteria. All the patients were monitored prospectively at the sarcoidosis clinic of the hospital. Skin biopsies were performed when granulomatous cutaneous involvement was suspected clinically.</p><p><b>Results </b> Granulomatous cutaneous involvement was demonstrated in 85 of 480 patients with systemic sarcoidosis. In 10 of these 85 patients subcutaneous sarcoidosis was diagnosed (11·8%). The lesions were most frequently located in the extremities, involving the forearms in nine patients. Indurated linear bands from the elbow to the hand were observed in five patients. In all of our patients the subcutaneous nodules appeared at the beginning of the disease. In six patients, the nodules remitted spontaneously in less than 2 years. In two cases foreign particles were detected under polarized light.</p><p><b>Conclusions </b> Subcutaneous sarcoidosis is a quite uniform clinicopathological entity usually appearing at the beginning of the disease. It usually heralds forms of sarcoidosis with nonsevere systemic involvement and is not associated with chronic fibrotic disease.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>Conflicts of interest: None declared.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subcutaneous sarcoidosis—clinicopathological study of 10 cases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Subcutaneous sarcoidosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subcutaneous sarcoidosis—clinicopathological study of 10 cases</title></titleInfo><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Marcoval</namePart><affiliation>Departments of Dermatology, Internal Medicine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Maña</namePart><affiliation>Departments of Dermatology, Internal Medicine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Moreno</namePart><affiliation>Pathology, Hospital de Bellvitge, c/Feixa Llarga s/n, Hospitalet de Llobregat, University of Barcelona, 08907 Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Peyri</namePart><affiliation>Departments of Dermatology, Internal Medicine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Science Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2005-10</dateIssued><edition>Accepted for publication 22 February 2005</edition><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="formulas">0</extent><extent unit="references">16</extent><extent unit="linksCrossRef">0</extent><extent unit="words">2079</extent></physicalDescription><abstract lang="en">Background Subcutaneous sarcoidosis is a specific cutaneous lesion of sarcoidosis that is rarely reported. Objective Our purpose was to analyse the clinicopathological features of 10 patients with subcutaneous sarcoidosis and its relationship with the systemic features of the disease. Patients and methods The patients with systemic sarcoidosis, diagnosed from 1974 to 2002 at a university hospital in Barcelona, Spain, who developed subcutaneous involvement, were included in the study. The diagnosis of systemic sarcoidosis was made according to conventional criteria. All the patients were monitored prospectively at the sarcoidosis clinic of the hospital. Skin biopsies were performed when granulomatous cutaneous involvement was suspected clinically. Results Granulomatous cutaneous involvement was demonstrated in 85 of 480 patients with systemic sarcoidosis. In 10 of these 85 patients subcutaneous sarcoidosis was diagnosed (11·8%). The lesions were most frequently located in the extremities, involving the forearms in nine patients. Indurated linear bands from the elbow to the hand were observed in five patients. In all of our patients the subcutaneous nodules appeared at the beginning of the disease. In six patients, the nodules remitted spontaneously in less than 2 years. In two cases foreign particles were detected under polarized light. Conclusions Subcutaneous sarcoidosis is a quite uniform clinicopathological entity usually appearing at the beginning of the disease. 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