EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics
Identifieur interne : 002032 ( Istex/Corpus ); précédent : 002031; suivant : 002033EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics
Auteurs : G. Bertsias ; J P A. Ioannidis ; J. Boletis ; S. Bombardieri ; R. Cervera ; C. Dostal ; J. Font ; I M Gilboe ; F. Houssiau ; T. Huizinga ; D. Isenberg ; C G M. Kallenberg ; M. Khamashta ; J C Piette ; M. Schneider ; J. Smolen ; G. Sturfelt ; A. Tincani ; R. Van Vollenhoven ; C. Gordon ; D T BoumpasSource :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2008-02.
English descriptors
- Teeft :
- Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid syndrome, Arthritis, Arthritis rheum, Aspirin, Azathioprine, Boumpas, Cohort, Cyclophosphamide, Damage accrual, Disease activity, Engl, Erythematosus, Eular, Expert committee, Expert opinion, Fetal, Gladman, Glucocorticoid, Hydroxychloroquine, Immunosuppressive, Induction therapy, Intravenous, Lupus, Lupus erythematosus, Lupus nephritis, Lupus pregnancy, Mofetil, Morbidity, Mycophenolate, Mycophenolate mofetil, Nephritis, Neuropsychiatric, Neuropsychiatric lupus, Neuropsychiatric manifestations, Oral anticoagulation, Osteoporosis, Predictor, Pregnancy, Pregnancy loss, Prognostic, Proliferative, Proliferative lupus nephritis, Prospective study, Randomised trials, Randomized, Recurrent thrombosis, Relapse, Renal, Renal disease, Renal transplantation, Rheum, Rheumatol, Rheumatology, Risk factors, Syndrome, Systemic, Systemic lupus erythematosus, Thrombosis, Transplantation, Urowitz.
Abstract
Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries’ strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists. Results: Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10. Conclusion: Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.
Url:
DOI: 10.1136/ard.2007.070367
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ISTEX:9EC1EC4D4605034B84CDC6079EBC6A951199B10DLe document en format XML
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Schneider</name><affiliation><mods:affiliation>Rheumatolology, Clinic of Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Dusseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Smolen, J" sort="Smolen, J" uniqKey="Smolen J" first="J" last="Smolen">J. Smolen</name><affiliation><mods:affiliation>Department of Rheumatology, Medical University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Sturfelt, G" sort="Sturfelt, G" uniqKey="Sturfelt G" first="G" last="Sturfelt">G. Sturfelt</name><affiliation><mods:affiliation>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Tincani, A" sort="Tincani, A" uniqKey="Tincani A" first="A" last="Tincani">A. Tincani</name><affiliation><mods:affiliation>Rheumatologia e Immunologia Clinica, Ospedale Civile di Brescia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Van Vollenhoven, R" sort="Van Vollenhoven, R" uniqKey="Van Vollenhoven R" first="R" last="Van Vollenhoven">R. Van Vollenhoven</name><affiliation><mods:affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Gordon, C" sort="Gordon, C" uniqKey="Gordon C" first="C" last="Gordon">C. Gordon</name><affiliation><mods:affiliation>Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK</mods:affiliation></affiliation></author><author><name sortKey="Boumpas, D T" sort="Boumpas, D T" uniqKey="Boumpas D" first="D T" last="Boumpas">D T Boumpas</name><affiliation><mods:affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9EC1EC4D4605034B84CDC6079EBC6A951199B10D</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1136/ard.2007.070367</idno><idno type="url">https://api.istex.fr/ark:/67375/NVC-QPDVFTS0-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002032</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002032</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</title><author><name sortKey="Bertsias, G" sort="Bertsias, G" uniqKey="Bertsias G" first="G" last="Bertsias">G. Bertsias</name><affiliation><mods:affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</mods:affiliation></affiliation></author><author><name sortKey="Ioannidis, J P A" sort="Ioannidis, J P A" uniqKey="Ioannidis J" first="J P A" last="Ioannidis">J P A. Ioannidis</name><affiliation><mods:affiliation>Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</mods:affiliation></affiliation></author><author><name sortKey="Boletis, J" sort="Boletis, J" uniqKey="Boletis J" first="J" last="Boletis">J. Boletis</name><affiliation><mods:affiliation>Department of Nephrology and Transplantation Medicine, Laiko Hospital, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Bombardieri, S" sort="Bombardieri, S" uniqKey="Bombardieri S" first="S" last="Bombardieri">S. Bombardieri</name><affiliation><mods:affiliation>Cattedra di Reumatologia, Universita di Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cervera, R" sort="Cervera, R" uniqKey="Cervera R" first="R" last="Cervera">R. Cervera</name><affiliation><mods:affiliation>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Dostal, C" sort="Dostal, C" uniqKey="Dostal C" first="C" last="Dostal">C. Dostal</name><affiliation><mods:affiliation>Institute of Rheumatology, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="Font, J" sort="Font, J" uniqKey="Font J" first="J" last="Font">J. Font</name><affiliation><mods:affiliation>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gilboe, I M" sort="Gilboe, I M" uniqKey="Gilboe I" first="I M" last="Gilboe">I M Gilboe</name><affiliation><mods:affiliation>Department of Rheumatology, Rikshospitalet, Oslo, Norway</mods:affiliation></affiliation></author><author><name sortKey="Houssiau, F" sort="Houssiau, F" uniqKey="Houssiau F" first="F" last="Houssiau">F. Houssiau</name><affiliation><mods:affiliation>Rheumatology Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Huizinga, T" sort="Huizinga, T" uniqKey="Huizinga T" first="T" last="Huizinga">T. Huizinga</name><affiliation><mods:affiliation>Department of Rheumatology Leiden University Medical Center, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Isenberg, D" sort="Isenberg, D" uniqKey="Isenberg D" first="D" last="Isenberg">D. Isenberg</name><affiliation><mods:affiliation>Centre for Rheumatology, University College London Hospitals, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Kallenberg, C G M" sort="Kallenberg, C G M" uniqKey="Kallenberg C" first="C G M" last="Kallenberg">C G M. Kallenberg</name><affiliation><mods:affiliation>Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Khamashta, M" sort="Khamashta, M" uniqKey="Khamashta M" first="M" last="Khamashta">M. Khamashta</name><affiliation><mods:affiliation>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Piette, J C" sort="Piette, J C" uniqKey="Piette J" first="J C" last="Piette">J C Piette</name><affiliation><mods:affiliation>Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Schneider, M" sort="Schneider, M" uniqKey="Schneider M" first="M" last="Schneider">M. Schneider</name><affiliation><mods:affiliation>Rheumatolology, Clinic of Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Dusseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Smolen, J" sort="Smolen, J" uniqKey="Smolen J" first="J" last="Smolen">J. Smolen</name><affiliation><mods:affiliation>Department of Rheumatology, Medical University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Sturfelt, G" sort="Sturfelt, G" uniqKey="Sturfelt G" first="G" last="Sturfelt">G. Sturfelt</name><affiliation><mods:affiliation>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Tincani, A" sort="Tincani, A" uniqKey="Tincani A" first="A" last="Tincani">A. Tincani</name><affiliation><mods:affiliation>Rheumatologia e Immunologia Clinica, Ospedale Civile di Brescia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Van Vollenhoven, R" sort="Van Vollenhoven, R" uniqKey="Van Vollenhoven R" first="R" last="Van Vollenhoven">R. Van Vollenhoven</name><affiliation><mods:affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Gordon, C" sort="Gordon, C" uniqKey="Gordon C" first="C" last="Gordon">C. Gordon</name><affiliation><mods:affiliation>Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK</mods:affiliation></affiliation></author><author><name sortKey="Boumpas, D T" sort="Boumpas, D T" uniqKey="Boumpas D" first="D T" last="Boumpas">D T Boumpas</name><affiliation><mods:affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2008-02">2008-02</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="195">195</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antiphospholipid</term><term>Antiphospholipid antibodies</term><term>Antiphospholipid syndrome</term><term>Arthritis</term><term>Arthritis rheum</term><term>Aspirin</term><term>Azathioprine</term><term>Boumpas</term><term>Cohort</term><term>Cyclophosphamide</term><term>Damage accrual</term><term>Disease activity</term><term>Engl</term><term>Erythematosus</term><term>Eular</term><term>Expert committee</term><term>Expert opinion</term><term>Fetal</term><term>Gladman</term><term>Glucocorticoid</term><term>Hydroxychloroquine</term><term>Immunosuppressive</term><term>Induction therapy</term><term>Intravenous</term><term>Lupus</term><term>Lupus erythematosus</term><term>Lupus nephritis</term><term>Lupus pregnancy</term><term>Mofetil</term><term>Morbidity</term><term>Mycophenolate</term><term>Mycophenolate mofetil</term><term>Nephritis</term><term>Neuropsychiatric</term><term>Neuropsychiatric lupus</term><term>Neuropsychiatric manifestations</term><term>Oral anticoagulation</term><term>Osteoporosis</term><term>Predictor</term><term>Pregnancy</term><term>Pregnancy loss</term><term>Prognostic</term><term>Proliferative</term><term>Proliferative lupus nephritis</term><term>Prospective study</term><term>Randomised trials</term><term>Randomized</term><term>Recurrent thrombosis</term><term>Relapse</term><term>Renal</term><term>Renal disease</term><term>Renal transplantation</term><term>Rheum</term><term>Rheumatol</term><term>Rheumatology</term><term>Risk factors</term><term>Syndrome</term><term>Systemic</term><term>Systemic lupus erythematosus</term><term>Thrombosis</term><term>Transplantation</term><term>Urowitz</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries’ strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists. Results: Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10. Conclusion: Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>lupus</json:string><json:string>erythematosus</json:string><json:string>systemic lupus erythematosus</json:string><json:string>nephritis</json:string><json:string>antiphospholipid</json:string><json:string>lupus nephritis</json:string><json:string>rheum</json:string><json:string>rheumatology</json:string><json:string>rheumatol</json:string><json:string>transplantation</json:string><json:string>renal</json:string><json:string>engl</json:string><json:string>cyclophosphamide</json:string><json:string>systemic</json:string><json:string>thrombosis</json:string><json:string>cohort</json:string><json:string>antiphospholipid antibodies</json:string><json:string>azathioprine</json:string><json:string>immunosuppressive</json:string><json:string>antiphospholipid syndrome</json:string><json:string>randomized</json:string><json:string>eular</json:string><json:string>mycophenolate</json:string><json:string>mofetil</json:string><json:string>proliferative</json:string><json:string>glucocorticoid</json:string><json:string>morbidity</json:string><json:string>prognostic</json:string><json:string>predictor</json:string><json:string>renal disease</json:string><json:string>mycophenolate mofetil</json:string><json:string>urowitz</json:string><json:string>gladman</json:string><json:string>intravenous</json:string><json:string>disease activity</json:string><json:string>boumpas</json:string><json:string>hydroxychloroquine</json:string><json:string>induction therapy</json:string><json:string>relapse</json:string><json:string>fetal</json:string><json:string>arthritis rheum</json:string><json:string>pregnancy</json:string><json:string>risk factors</json:string><json:string>expert committee</json:string><json:string>lupus erythematosus</json:string><json:string>lupus pregnancy</json:string><json:string>randomised trials</json:string><json:string>recurrent thrombosis</json:string><json:string>prospective study</json:string><json:string>pregnancy loss</json:string><json:string>syndrome</json:string><json:string>neuropsychiatric</json:string><json:string>aspirin</json:string><json:string>osteoporosis</json:string><json:string>renal transplantation</json:string><json:string>damage accrual</json:string><json:string>expert opinion</json:string><json:string>neuropsychiatric lupus</json:string><json:string>oral anticoagulation</json:string><json:string>neuropsychiatric manifestations</json:string><json:string>proliferative lupus nephritis</json:string><json:string>arthritis</json:string><json:string>anticoagulation</json:string><json:string>heart block</json:string><json:string>clinical course</json:string><json:string>lupus patients</json:string><json:string>primary prevention</json:string><json:string>immunological tests</json:string><json:string>young investigator research award</json:string><json:string>oral contraceptives</json:string><json:string>secondary prevention</json:string><json:string>maintenance therapy</json:string><json:string>cardiovascular disease</json:string><json:string>optimal management</json:string><json:string>pregnant patients</json:string><json:string>diffuse proliferative lupus nephritis</json:string><json:string>antiphospholipid antibody syndrome</json:string><json:string>crete school</json:string><json:string>severe lupus nephritis</json:string><json:string>pulse cyclophosphamide</json:string><json:string>renal biopsy</json:string><json:string>lupus anticoagulant</json:string><json:string>arch intern</json:string><json:string>immunosuppressive agents</json:string><json:string>diagnostic ability</json:string><json:string>pregnancy outcome</json:string><json:string>immunosuppressive therapy</json:string><json:string>flare</json:string><json:string>prognosis</json:string></teeft></keywords><author><json:item><name>G Bertsias</name><affiliations><json:string>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</json:string></affiliations></json:item><json:item><name>J P A Ioannidis</name><affiliations><json:string>Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>J Boletis</name><affiliations><json:string>Department of Nephrology and Transplantation Medicine, Laiko Hospital, Athens, Greece</json:string></affiliations></json:item><json:item><name>S Bombardieri</name><affiliations><json:string>Cattedra di Reumatologia, Universita di Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>R Cervera</name><affiliations><json:string>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>C Dostal</name><affiliations><json:string>Institute of Rheumatology, Prague, Czech Republic</json:string></affiliations></json:item><json:item><name>J Font</name><affiliations><json:string>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>I M Gilboe</name><affiliations><json:string>Department of Rheumatology, Rikshospitalet, Oslo, Norway</json:string></affiliations></json:item><json:item><name>F Houssiau</name><affiliations><json:string>Rheumatology Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>T Huizinga</name><affiliations><json:string>Department of Rheumatology Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>D Isenberg</name><affiliations><json:string>Centre for Rheumatology, University College London Hospitals, London, UK</json:string></affiliations></json:item><json:item><name>C G M Kallenberg</name><affiliations><json:string>Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>M Khamashta</name><affiliations><json:string>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK</json:string></affiliations></json:item><json:item><name>J C Piette</name><affiliations><json:string>Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>M Schneider</name><affiliations><json:string>Rheumatolology, Clinic of Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Dusseldorf, Germany</json:string></affiliations></json:item><json:item><name>J Smolen</name><affiliations><json:string>Department of Rheumatology, Medical University of Vienna, Austria</json:string></affiliations></json:item><json:item><name>G Sturfelt</name><affiliations><json:string>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</json:string></affiliations></json:item><json:item><name>A Tincani</name><affiliations><json:string>Rheumatologia e Immunologia Clinica, Ospedale Civile di Brescia, Italy</json:string></affiliations></json:item><json:item><name>R van Vollenhoven</name><affiliations><json:string>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</json:string></affiliations></json:item><json:item><name>C Gordon</name><affiliations><json:string>Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK</json:string></affiliations></json:item><json:item><name>D T Boumpas</name><affiliations><json:string>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</json:string></affiliations></json:item></author><articleId><json:string>ar70367</json:string></articleId><arkIstex>ark:/67375/NVC-QPDVFTS0-F</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries’ strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists. Results: Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10. Conclusion: Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.</abstract><qualityIndicators><score>9.748</score><pdfWordCount>8703</pdfWordCount><pdfCharCount>62850</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>229</abstractWordCount><abstractCharCount>1645</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</title><pmid><json:string>17504841</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Annals of the Rheumatic Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0003-4967</json:string></issn><eissn><json:string>1468-2060</json:string></eissn><publisherId><json:string>ard</json:string></publisherId><volume>67</volume><issue>2</issue><pages><first>195</first></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Unlocked</value></json:item><json:item><value>Immunology (including allergy)</value></json:item><json:item><value>Renal medicine</value></json:item><json:item><value>Connective tissue disease</value></json:item><json:item><value>Systemic lupus erythematosus</value></json:item></subject></host><namedEntities><unitex><date><json:string>2007-05-15</json:string></date><geogName></geogName><orgName><json:string>Institute of Rheumatology, Prague, Czech Republic</json:string><json:string>University of Birmingham</json:string><json:string>AGREE</json:string><json:string>Division of Immunity</json:string><json:string>Department of Nephrology and Transplantation</json:string><json:string>University of Crete School of Medicine</json:string><json:string>United States Food</json:string><json:string>Lupus Research Unit, The Rayne Institute, St Thomas</json:string><json:string>Hospital, London, UK</json:string><json:string>Department of Hygiene and Epidemiology</json:string><json:string>Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands</json:string><json:string>Department of Rheumatology Leiden University Medical Center, Leiden, The Netherlands</json:string><json:string>Rheumatology Department, Universite</json:string><json:string>Laiko Hospital, Athens, Greece</json:string><json:string>Standing Committee for International Clinical Studies Including Therapeutics G Bertsias</json:string><json:string>UK Correspondence</json:string><json:string>Department of Rheumatology, Medical University of Vienna, Austria</json:string><json:string>Research Agenda</json:string><json:string>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</json:string><json:string>Department of Rheumatology, Rikshospitalet, Oslo, Norway</json:string><json:string>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</json:string><json:string>University of Ioannina School of Medicine</json:string><json:string>Guidelines Research and Evaluation</json:string><json:string>Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</json:string><json:string>EULAR Excecutive Committee</json:string></orgName><orgName_funder><json:string>EULAR Excecutive Committee</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Elly Wyss</json:string><json:string>Ann Rheum</json:string><json:string>Font</json:string><json:string>Robert Buff</json:string><json:string>George Bertsias</json:string><json:string>Michael Ward</json:string><json:string>Natassa Mpizaki</json:string><json:string>Extended</json:string><json:string>Jose Font</json:string><json:string>Gabor Illei</json:string><json:string>Ernst Isler</json:string><json:string>Dr Maxime</json:string><json:string>London Hospitals</json:string></persName><placeName><json:string>Delphi</json:string><json:string>Dusseldorf</json:string><json:string>Birmingham</json:string><json:string>Paris</json:string><json:string>Germany</json:string><json:string>Greece</json:string><json:string>Brescia</json:string><json:string>UK</json:string><json:string>Pisa</json:string><json:string>Heraklion</json:string><json:string>London</json:string><json:string>Europe</json:string><json:string>Brussels</json:string><json:string>Ioannina</json:string><json:string>France</json:string><json:string>Italy</json:string><json:string>Zurich</json:string><json:string>Belgium</json:string></placeName><ref_url><json:string>http://ard.bmj.com</json:string></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/NVC-QPDVFTS0-F</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - rheumatology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - arthritis & rheumatology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - General Biochemistry, Genetics and Molecular Biology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Rheumatology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pathologie osteoarticulaire</json:string></inist></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1136/ard.2007.070367</json:string></doi><id>9EC1EC4D4605034B84CDC6079EBC6A951199B10D</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-QPDVFTS0-F/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-QPDVFTS0-F/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/NVC-QPDVFTS0-F/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><availability><licence><p>2008 BMJ Publishing Group and European League Against Rheumatism</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</p></availability><date>2007-05-15</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>This is an abbreviated version of the recommendations. The full-text version is available online (http://ard.bmj.com)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</title><author xml:id="author-0000"><persName><forename type="first">G</forename><surname>Bertsias</surname></persName><affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</affiliation></author><author xml:id="author-0001"><persName><forename type="first">J P A</forename><surname>Ioannidis</surname></persName><affiliation>Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J</forename><surname>Boletis</surname></persName><affiliation>Department of Nephrology and Transplantation Medicine, Laiko Hospital, Athens, Greece</affiliation></author><author xml:id="author-0003"><persName><forename type="first">S</forename><surname>Bombardieri</surname></persName><affiliation>Cattedra di Reumatologia, Universita di Pisa, Pisa, Italy</affiliation></author><author xml:id="author-0004"><persName><forename type="first">R</forename><surname>Cervera</surname></persName><affiliation>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</affiliation></author><author xml:id="author-0005"><persName><forename type="first">C</forename><surname>Dostal</surname></persName><affiliation>Institute of Rheumatology, Prague, Czech Republic</affiliation></author><author xml:id="author-0006"><persName><forename type="first">J</forename><surname>Font</surname></persName><affiliation>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</affiliation></author><author xml:id="author-0007"><persName><forename type="first">I M</forename><surname>Gilboe</surname></persName><affiliation>Department of Rheumatology, Rikshospitalet, Oslo, Norway</affiliation></author><author xml:id="author-0008"><persName><forename type="first">F</forename><surname>Houssiau</surname></persName><affiliation>Rheumatology Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium</affiliation></author><author xml:id="author-0009"><persName><forename type="first">T</forename><surname>Huizinga</surname></persName><affiliation>Department of Rheumatology Leiden University Medical Center, Leiden, The Netherlands</affiliation></author><author xml:id="author-0010"><persName><forename type="first">D</forename><surname>Isenberg</surname></persName><affiliation>Centre for Rheumatology, University College London Hospitals, London, UK</affiliation></author><author xml:id="author-0011"><persName><forename type="first">C G M</forename><surname>Kallenberg</surname></persName><affiliation>Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands</affiliation></author><author xml:id="author-0012"><persName><forename type="first">M</forename><surname>Khamashta</surname></persName><affiliation>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK</affiliation></author><author xml:id="author-0013"><persName><forename type="first">J C</forename><surname>Piette</surname></persName><affiliation>Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</affiliation></author><author xml:id="author-0014"><persName><forename type="first">M</forename><surname>Schneider</surname></persName><affiliation>Rheumatolology, Clinic of Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Dusseldorf, Germany</affiliation></author><author xml:id="author-0015"><persName><forename type="first">J</forename><surname>Smolen</surname></persName><affiliation>Department of Rheumatology, Medical University of Vienna, Austria</affiliation></author><author xml:id="author-0016"><persName><forename type="first">G</forename><surname>Sturfelt</surname></persName><affiliation>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</affiliation></author><author xml:id="author-0017"><persName><forename type="first">A</forename><surname>Tincani</surname></persName><affiliation>Rheumatologia e Immunologia Clinica, Ospedale Civile di Brescia, Italy</affiliation></author><author xml:id="author-0018"><persName><forename type="first">R</forename><surname>van Vollenhoven</surname></persName><affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</affiliation></author><author xml:id="author-0019"><persName><forename type="first">C</forename><surname>Gordon</surname></persName><affiliation>Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK</affiliation></author><author xml:id="author-0020"><persName><forename type="first">D T</forename><surname>Boumpas</surname></persName><affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</affiliation></author><idno type="istex">9EC1EC4D4605034B84CDC6079EBC6A951199B10D</idno><idno type="ark">ark:/67375/NVC-QPDVFTS0-F</idno><idno type="DOI">10.1136/ard.2007.070367</idno><idno type="href">annrheumdis-67-195.pdf</idno><idno type="article-id">ar70367</idno><idno type="PMID">17504841</idno><idno type="local">annrheumdis;67/2/195</idno></analytic><monogr><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="pISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><idno type="publisher-id">ard</idno><idno type="PublisherID-hwp">annrheumdis</idno><idno type="PublisherID-nlm-ta">Ann Rheum Dis</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2008-02"></date><biblScope unit="volume">67</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="195">195</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007-05-15</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries’ strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists. Results: Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10. Conclusion: Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Unlocked</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Immunology (including allergy)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Renal medicine</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Connective tissue disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Systemic lupus erythematosus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-05-15">Created</change><change when="2008-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-QPDVFTS0-F/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">annrheumdis</journal-id><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-id journal-id-type="publisher-id">ard</journal-id><journal-title>Annals of the Rheumatic Diseases</journal-title><abbrev-journal-title abbrev-type="publisher">Ann Rheum Dis</abbrev-journal-title><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn><publisher><publisher-name>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">ar70367</article-id><article-id pub-id-type="doi">10.1136/ard.2007.070367</article-id><article-id pub-id-type="other">annrheumdis;67/2/195</article-id><article-id pub-id-type="other">annrheumdis;ard.2007.070367</article-id><article-id pub-id-type="pmid">17504841</article-id><article-id pub-id-type="other">195</article-id><article-id pub-id-type="other">ard.2007.070367</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Extended reports</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Unlocked</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Immunology (including allergy)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Renal medicine</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Connective tissue disease</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Systemic lupus erythematosus</subject></subj-group></article-categories><title-group><article-title>EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</article-title><alt-title alt-title-type="running-head">Extended report</alt-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Bertsias</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ioannidis</surname><given-names>J P A</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Boletis</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Bombardieri</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Cervera</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Dostal</surname><given-names>C</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Font</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Gilboe</surname><given-names>I M</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Houssiau</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Huizinga</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Isenberg</surname><given-names>D</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kallenberg</surname><given-names>C G M</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Khamashta</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Piette</surname><given-names>J C</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Schneider</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Smolen</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Sturfelt</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Tincani</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>van Vollenhoven</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Gordon</surname><given-names>C</given-names></name><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Boumpas</surname><given-names>D T</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Nephrology and Transplantation Medicine, Laiko Hospital, Athens, Greece</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Cattedra di Reumatologia, Universita di Pisa, Pisa, Italy</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Institute of Rheumatology, Prague, Czech Republic</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Department of Rheumatology, Rikshospitalet, Oslo, Norway</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Rheumatology Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium</addr-line></aff><aff id="aff9"><label>9</label><addr-line>Department of Rheumatology Leiden University Medical Center, Leiden, The Netherlands</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Centre for Rheumatology, University College London Hospitals, London, UK</addr-line></aff><aff id="aff11"><label>11</label><addr-line>Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK</addr-line></aff><aff id="aff13"><label>13</label><addr-line>Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</addr-line></aff><aff id="aff14"><label>14</label><addr-line>Rheumatolology, Clinic of Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Dusseldorf, Germany</addr-line></aff><aff id="aff15"><label>15</label><addr-line>Department of Rheumatology, Medical University of Vienna, Austria</addr-line></aff><aff id="aff16"><label>16</label><addr-line>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</addr-line></aff><aff id="aff17"><label>17</label><addr-line>Rheumatologia e Immunologia Clinica, Ospedale Civile di Brescia, Italy</addr-line></aff><aff id="aff18"><label>18</label><addr-line>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</addr-line></aff><aff id="aff19"><label>19</label><addr-line>Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK</addr-line></aff><author-notes><corresp>D T Boumpas, Departments of Internal Medicine and Rheumatology, University of Crete School of Medicine, 71003, Heraklion, Greece; <email xlink:type="simple">boumpasd@med.uoc.gr</email></corresp><fn fn-type="other"><p>This is an abbreviated version of the recommendations. The full-text version is available online (<ext-link ext-link-type="uri" xlink:href="http://ard.bmj.com" xlink:type="simple">http://ard.bmj.com</ext-link>)</p></fn><fn fn-type="other"><p>Dr Font died on 26 July 2006.</p></fn></author-notes><pub-date pub-type="ppub"><month>2</month><year>2008</year></pub-date><pub-date pub-type="epub-original"><day>5</day><month>7</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>15</day><month>5</month><year>2007</year></pub-date><volume>67</volume><volume-id pub-id-type="other">67</volume-id><volume-id pub-id-type="other">67</volume-id><issue>2</issue><issue-id pub-id-type="other">annrheumdis;67/2</issue-id><issue-id pub-id-type="other">2</issue-id><issue-id pub-id-type="other">67/2</issue-id><fpage>195</fpage><history><date date-type="accepted"><day>30</day><month>4</month><year>2007</year></date></history><permissions><copyright-statement>2008 BMJ Publishing Group and European League Against Rheumatism</copyright-statement><copyright-year>2008</copyright-year><license license-type="open-access" xlink:type="simple"><p></p></license></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="annrheumdis-67-195.pdf"></self-uri><abstract><sec><title>Objective:</title><p>Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE.</p></sec><sec><title>Methods:</title><p>The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries’ strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists.</p></sec><sec><title>Results:</title><p>Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10.</p></sec><sec><title>Conclusion:</title><p>Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Bertsias</namePart><affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J P A</namePart><namePart type="family">Ioannidis</namePart><affiliation>Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Boletis</namePart><affiliation>Department of Nephrology and Transplantation Medicine, Laiko Hospital, Athens, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Bombardieri</namePart><affiliation>Cattedra di Reumatologia, Universita di Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Cervera</namePart><affiliation>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Dostal</namePart><affiliation>Institute of Rheumatology, Prague, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Font</namePart><affiliation>Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I M</namePart><namePart type="family">Gilboe</namePart><affiliation>Department of Rheumatology, Rikshospitalet, Oslo, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Houssiau</namePart><affiliation>Rheumatology Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Huizinga</namePart><affiliation>Department of Rheumatology Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Isenberg</namePart><affiliation>Centre for Rheumatology, University College London Hospitals, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C G M</namePart><namePart type="family">Kallenberg</namePart><affiliation>Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Khamashta</namePart><affiliation>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J C</namePart><namePart type="family">Piette</namePart><affiliation>Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schneider</namePart><affiliation>Rheumatolology, Clinic of Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Dusseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Smolen</namePart><affiliation>Department of Rheumatology, Medical University of Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Sturfelt</namePart><affiliation>Department of Rheumatology, University Hospital of Lund, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Tincani</namePart><affiliation>Rheumatologia e Immunologia Clinica, Ospedale Civile di Brescia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">van Vollenhoven</namePart><affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Gordon</namePart><affiliation>Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D T</namePart><namePart type="family">Boumpas</namePart><affiliation>Internal Medicine, and Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><dateIssued encoding="w3cdtf">2008-02</dateIssued><dateCreated encoding="w3cdtf">2007-05-15</dateCreated><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries’ strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists. Results: Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10. Conclusion: Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.</abstract><note type="footnotes">This is an abbreviated version of the recommendations. The full-text version is available online (http://ard.bmj.com)</note><relatedItem type="host"><titleInfo><title>Annals of the Rheumatic Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Ann Rheum Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>hwp-journal-coll</genre><topic>Unlocked</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Immunology (including allergy)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Renal medicine</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Connective tissue disease</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Systemic lupus erythematosus</topic></subject><identifier type="ISSN">0003-4967</identifier><identifier type="eISSN">1468-2060</identifier><identifier type="PublisherID">ard</identifier><identifier type="PublisherID-hwp">annrheumdis</identifier><identifier type="PublisherID-nlm-ta">Ann Rheum Dis</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>195</start></extent></part></relatedItem><identifier type="istex">9EC1EC4D4605034B84CDC6079EBC6A951199B10D</identifier><identifier type="ark">ark:/67375/NVC-QPDVFTS0-F</identifier><identifier type="DOI">10.1136/ard.2007.070367</identifier><identifier type="href">annrheumdis-67-195.pdf</identifier><identifier type="ArticleID">ar70367</identifier><identifier type="PMID">17504841</identifier><identifier type="local">annrheumdis;67/2/195</identifier><accessCondition type="use and reproduction" contentType="copyright">2008 BMJ Publishing Group and European League Against Rheumatism</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>2008 BMJ Publishing Group and European League Against Rheumatism</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-QPDVFTS0-F/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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