Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria
Identifieur interne : 002030 ( Istex/Corpus ); précédent : 002029; suivant : 002031Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria
Auteurs : Pheng Soon Lee ; Edwin Y L. LauSource :
- British Medical Journal (Clinical research ed.) [ 0267-0623 ] ; 1988-03-26.
English descriptors
- Teeft :
- Antimalarial, Antimalarial prophylaxis, Asthma, Bronchitis, Chronic bronchitis, Chronic cough, Common infections, Concurrent infections, Control group, Control groups, Drug combination, Early childhood, First choice, First month, Harder training, Immunoglobulin concentrations, Infection, Journal volume, Local patterns, Lung function, Medical research council, Military recruits, National child development study, Natural history, Odds ratio, Officer cadets, Other drugs, Overall risk, Physical activity, Physical training, Prophylactic, Prophylaxis, Recruits duringfirst, Respiratory disease, Respiratory tract infections, Same training tasks, Second month, Significant immunosuppression, Singapore, Sprain, Study group, Synergistic effect, Third months, Tract infection, Tract infections, Training population, Whooping cough, Young adults.
Abstract
The relative risks of non-specific upper respiratory tract infections were studied in two well matched groups of military recruits to see whether dapsone-pyrimethamine (Maloprim) given as antimalarial prophylaxis was associated with immunosuppression. Mean risks of upper respiratory tract infection were 64% higher in the study group than in the controls, the largest monthly differences being recorded in the months of harder training. These findings were unlikely to have been due solely to harder training in the study group, as concurrently measured sprains (arguably more likely to have been affected) were increased by only 19%. A more likely explanation was some degree of immunosuppression, physical stress possibly having a synergistic effect. These findings suggest that travellers taking dapsone-pyrimethamine as antimalarial prophylaxis may be rendered more susceptible to commoner infections, especially when engaged in increased physical activity.
Url:
DOI: 10.1136/bmj.296.6626.893
Links to Exploration step
ISTEX:BC5B779C71443D1410CE0E7933CD10602E88C9AALe document en format XML
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Lau</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BC5B779C71443D1410CE0E7933CD10602E88C9AA</idno><date when="1988" year="1988">1988</date><idno type="doi">10.1136/bmj.296.6626.893</idno><idno type="url">https://api.istex.fr/ark:/67375/NVC-1TL6JXBF-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002030</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002030</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria</title><author><name sortKey="Lee, Pheng Soon" sort="Lee, Pheng Soon" uniqKey="Lee P" first="Pheng Soon" last="Lee">Pheng Soon Lee</name></author><author><name sortKey="Lau, Edwin Y L" sort="Lau, Edwin Y L" uniqKey="Lau E" first="Edwin Y L" last="Lau">Edwin Y L. Lau</name></author></analytic><monogr></monogr><series><title level="j">British Medical Journal (Clinical research ed.)</title><title level="j" type="abbrev">Br Med J (Clin Res Ed)</title><idno type="ISSN">0267-0623</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="1988-03-26">1988-03-26</date><biblScope unit="volume">296</biblScope><biblScope unit="issue">6626</biblScope><biblScope unit="page" from="893">893</biblScope></imprint><idno type="ISSN">0267-0623</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0267-0623</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antimalarial</term><term>Antimalarial prophylaxis</term><term>Asthma</term><term>Bronchitis</term><term>Chronic bronchitis</term><term>Chronic cough</term><term>Common infections</term><term>Concurrent infections</term><term>Control group</term><term>Control groups</term><term>Drug combination</term><term>Early childhood</term><term>First choice</term><term>First month</term><term>Harder training</term><term>Immunoglobulin concentrations</term><term>Infection</term><term>Journal volume</term><term>Local patterns</term><term>Lung function</term><term>Medical research council</term><term>Military recruits</term><term>National child development study</term><term>Natural history</term><term>Odds ratio</term><term>Officer cadets</term><term>Other drugs</term><term>Overall risk</term><term>Physical activity</term><term>Physical training</term><term>Prophylactic</term><term>Prophylaxis</term><term>Recruits duringfirst</term><term>Respiratory disease</term><term>Respiratory tract infections</term><term>Same training tasks</term><term>Second month</term><term>Significant immunosuppression</term><term>Singapore</term><term>Sprain</term><term>Study group</term><term>Synergistic effect</term><term>Third months</term><term>Tract infection</term><term>Tract infections</term><term>Training population</term><term>Whooping cough</term><term>Young adults</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The relative risks of non-specific upper respiratory tract infections were studied in two well matched groups of military recruits to see whether dapsone-pyrimethamine (Maloprim) given as antimalarial prophylaxis was associated with immunosuppression. Mean risks of upper respiratory tract infection were 64% higher in the study group than in the controls, the largest monthly differences being recorded in the months of harder training. These findings were unlikely to have been due solely to harder training in the study group, as concurrently measured sprains (arguably more likely to have been affected) were increased by only 19%. A more likely explanation was some degree of immunosuppression, physical stress possibly having a synergistic effect. 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Mean risks of upper respiratory tract infection were 64% higher in the study group than in the controls, the largest monthly differences being recorded in the months of harder training. These findings were unlikely to have been due solely to harder training in the study group, as concurrently measured sprains (arguably more likely to have been affected) were increased by only 19%. A more likely explanation was some degree of immunosuppression, physical stress possibly having a synergistic effect. These findings suggest that travellers taking dapsone-pyrimethamine as antimalarial prophylaxis may be rendered more susceptible to commoner infections, especially when engaged in increased physical activity.</abstract><qualityIndicators><score>6.772</score><pdfWordCount>3152</pdfWordCount><pdfCharCount>20085</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>3</pdfPageCount><pdfPageSize>606.72 x 828 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>135</abstractWordCount><abstractCharCount>962</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria</title><pmid><json:string>3129063</json:string></pmid><genre><json:string>brief-communication</json:string></genre><host><title>British Medical Journal (Clinical research ed.)</title><language><json:string>unknown</json:string></language><issn><json:string>0267-0623</json:string></issn><eissn><json:string>1468-5833</json:string></eissn><volume>296</volume><issue>6626</issue><pages><first>893</first></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Infectious diseases</value></json:item></subject></host><namedEntities><unitex><date><json:string>1988-03-26</json:string></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/NVC-1TL6JXBF-9</json:string></ark><categories><inist><json:string>1 - 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Mean risks of upper respiratory tract infection were 64% higher in the study group than in the controls, the largest monthly differences being recorded in the months of harder training. These findings were unlikely to have been due solely to harder training in the study group, as concurrently measured sprains (arguably more likely to have been affected) were increased by only 19%. A more likely explanation was some degree of immunosuppression, physical stress possibly having a synergistic effect. 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Mean risks of upper respiratory tract infection were 64% higher in the study group than in the controls, the largest monthly differences being recorded in the months of harder training. These findings were unlikely to have been due solely to harder training in the study group, as concurrently measured sprains (arguably more likely to have been affected) were increased by only 19%. A more likely explanation was some degree of immunosuppression, physical stress possibly having a synergistic effect.</p><p>These findings suggest that travellers taking dapsone-pyrimethamine as antimalarial prophylaxis may be rendered more susceptible to commoner infections, especially when engaged in increased physical activity.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria</title></titleInfo><name type="personal"><namePart type="given">Pheng Soon</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edwin Y L</namePart><namePart type="family">Lau</namePart><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="brief-report" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>British Medical Journal Publishing Group</publisher><dateIssued encoding="w3cdtf">1988-03-26</dateIssued><dateCreated encoding="w3cdtf">1988-03-26</dateCreated><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">The relative risks of non-specific upper respiratory tract infections were studied in two well matched groups of military recruits to see whether dapsone-pyrimethamine (Maloprim) given as antimalarial prophylaxis was associated with immunosuppression. Mean risks of upper respiratory tract infection were 64% higher in the study group than in the controls, the largest monthly differences being recorded in the months of harder training. These findings were unlikely to have been due solely to harder training in the study group, as concurrently measured sprains (arguably more likely to have been affected) were increased by only 19%. A more likely explanation was some degree of immunosuppression, physical stress possibly having a synergistic effect. 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