Neurosarcoidosis
Identifieur interne : 001157 ( Istex/Corpus ); précédent : 001156; suivant : 001158Neurosarcoidosis
Auteurs : S. Marangoni ; V. Argentiero ; B. TavolatoSource :
- Journal of Neurology [ 0340-5354 ] ; 2006-04-01.
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Abstract
Abstract: Objective: Chronic involvement of the nervous system is relatively rare in sarcoidosis. We describe 7 cases that fulfil Zajicek's criteria for neurosarcoidosis (NS) and propose some modifications to such criteria. Materials and methods: The patients were admitted for various neurological syndromes: 2 cases presented with chronic lymphocytic meningitis, 4 with spinal cord symptoms, one case was initially confused with multiple sclerosis. Serological tests, immunological screening, cerebrospinal fluid (CSF) analysis, bacteriological and viral testing were performed in all patients. Spinal and cerebral MRI, gallium scan, bronchoscopy with biopsy and bronchoalveolar–lavage fluid analysis, high–resolution computed tomography (HRCT) of the chest, biopsy of the lungs, skin, mediastinal lymph–node and meninges, were useful in diagnosing NS. Results and discussion: Laboratory tests showed serum inflammatory abnormalities, but were negative for infectious diseases, while CSF showed inflammatory signs in all patients. MRI revealed meningeal enhancement or hypertrophic pachymeningeal lesions in 4 patients, white matter abnormalities and mass lesions in 2 patients, and a spinal mass lesion in 1 patient. Gallium scan, HRCT, bronchoscopy were positive in most cases. Patients were treated with steroid and immunosuppressive therapy, with improvement in six cases. One patient died from infectious complications. Conclusion: A definite diagnosis of NS requires demonstration of non–caseating granulomas affecting nervous tissues. In most cases, histological evidence of systemic disease (probable NS) is sufficient in the presence of compatible alterations in the CNS. In our patients the bronchoalveolarlavage fluid analysis, gallium scan, and chest HRCT were important for diagnosis,while serum ACE was always normal and chest radiographs were not suggestive of sarcoidosis.
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DOI: 10.1007/s00415-005-0043-5
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ISTEX:58EED0CB97350EA1A47B683F52DEA473E4825858Le document en format XML
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Tavolato</name><affiliation><mods:affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: bruno.tavolato@unipd.it</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:58EED0CB97350EA1A47B683F52DEA473E4825858</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1007/s00415-005-0043-5</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-P8DDP605-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001157</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neurosarcoidosis</title><author><name sortKey="Marangoni, S" sort="Marangoni, S" uniqKey="Marangoni S" first="S." last="Marangoni">S. Marangoni</name><affiliation><mods:affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</mods:affiliation></affiliation></author><author><name sortKey="Argentiero, V" sort="Argentiero, V" uniqKey="Argentiero V" first="V." last="Argentiero">V. Argentiero</name><affiliation><mods:affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</mods:affiliation></affiliation></author><author><name sortKey="Tavolato, B" sort="Tavolato, B" uniqKey="Tavolato B" first="B." last="Tavolato">B. Tavolato</name><affiliation><mods:affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: bruno.tavolato@unipd.it</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology</title><title level="j" type="abbrev">J Neurol</title><idno type="ISSN">0340-5354</idno><idno type="eISSN">1432-1459</idno><imprint><publisher>Steinkopff-Verlag</publisher><pubPlace>Darmstadt</pubPlace><date type="published" when="2006-04-01">2006-04-01</date><biblScope unit="volume">253</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="488">488</biblScope><biblScope unit="page" to="495">495</biblScope></imprint><idno type="ISSN">0340-5354</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-5354</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CNS diseases</term><term>inflammatory</term><term>neurosarcoidosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: Chronic involvement of the nervous system is relatively rare in sarcoidosis. We describe 7 cases that fulfil Zajicek's criteria for neurosarcoidosis (NS) and propose some modifications to such criteria. Materials and methods: The patients were admitted for various neurological syndromes: 2 cases presented with chronic lymphocytic meningitis, 4 with spinal cord symptoms, one case was initially confused with multiple sclerosis. Serological tests, immunological screening, cerebrospinal fluid (CSF) analysis, bacteriological and viral testing were performed in all patients. Spinal and cerebral MRI, gallium scan, bronchoscopy with biopsy and bronchoalveolar–lavage fluid analysis, high–resolution computed tomography (HRCT) of the chest, biopsy of the lungs, skin, mediastinal lymph–node and meninges, were useful in diagnosing NS. Results and discussion: Laboratory tests showed serum inflammatory abnormalities, but were negative for infectious diseases, while CSF showed inflammatory signs in all patients. MRI revealed meningeal enhancement or hypertrophic pachymeningeal lesions in 4 patients, white matter abnormalities and mass lesions in 2 patients, and a spinal mass lesion in 1 patient. Gallium scan, HRCT, bronchoscopy were positive in most cases. Patients were treated with steroid and immunosuppressive therapy, with improvement in six cases. One patient died from infectious complications. Conclusion: A definite diagnosis of NS requires demonstration of non–caseating granulomas affecting nervous tissues. In most cases, histological evidence of systemic disease (probable NS) is sufficient in the presence of compatible alterations in the CNS. In our patients the bronchoalveolarlavage fluid analysis, gallium scan, and chest HRCT were important for diagnosis,while serum ACE was always normal and chest radiographs were not suggestive of sarcoidosis.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Dr. ssa S. Marangoni</name><affiliations><json:string>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</json:string></affiliations></json:item><json:item><name>Dr. ssa V. Argentiero</name><affiliations><json:string>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</json:string></affiliations></json:item><json:item><name>Prof. B. Tavolato</name><affiliations><json:string>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</json:string><json:string>E-mail: bruno.tavolato@unipd.it</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>neurosarcoidosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CNS diseases</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inflammatory</value></json:item></subject><articleId><json:string>43</json:string><json:string>Art1</json:string></articleId><arkIstex>ark:/67375/VQC-P8DDP605-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Objective: Chronic involvement of the nervous system is relatively rare in sarcoidosis. We describe 7 cases that fulfil Zajicek's criteria for neurosarcoidosis (NS) and propose some modifications to such criteria. Materials and methods: The patients were admitted for various neurological syndromes: 2 cases presented with chronic lymphocytic meningitis, 4 with spinal cord symptoms, one case was initially confused with multiple sclerosis. Serological tests, immunological screening, cerebrospinal fluid (CSF) analysis, bacteriological and viral testing were performed in all patients. Spinal and cerebral MRI, gallium scan, bronchoscopy with biopsy and bronchoalveolar–lavage fluid analysis, high–resolution computed tomography (HRCT) of the chest, biopsy of the lungs, skin, mediastinal lymph–node and meninges, were useful in diagnosing NS. Results and discussion: Laboratory tests showed serum inflammatory abnormalities, but were negative for infectious diseases, while CSF showed inflammatory signs in all patients. MRI revealed meningeal enhancement or hypertrophic pachymeningeal lesions in 4 patients, white matter abnormalities and mass lesions in 2 patients, and a spinal mass lesion in 1 patient. Gallium scan, HRCT, bronchoscopy were positive in most cases. Patients were treated with steroid and immunosuppressive therapy, with improvement in six cases. One patient died from infectious complications. Conclusion: A definite diagnosis of NS requires demonstration of non–caseating granulomas affecting nervous tissues. In most cases, histological evidence of systemic disease (probable NS) is sufficient in the presence of compatible alterations in the CNS. 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We describe 7 cases that fulfil Zajicek's criteria for neurosarcoidosis (NS) and propose some modifications to such criteria. Materials and methods: The patients were admitted for various neurological syndromes: 2 cases presented with chronic lymphocytic meningitis, 4 with spinal cord symptoms, one case was initially confused with multiple sclerosis. Serological tests, immunological screening, cerebrospinal fluid (CSF) analysis, bacteriological and viral testing were performed in all patients. Spinal and cerebral MRI, gallium scan, bronchoscopy with biopsy and bronchoalveolar–lavage fluid analysis, high–resolution computed tomography (HRCT) of the chest, biopsy of the lungs, skin, mediastinal lymph–node and meninges, were useful in diagnosing NS. Results and discussion: Laboratory tests showed serum inflammatory abnormalities, but were negative for infectious diseases, while CSF showed inflammatory signs in all patients. MRI revealed meningeal enhancement or hypertrophic pachymeningeal lesions in 4 patients, white matter abnormalities and mass lesions in 2 patients, and a spinal mass lesion in 1 patient. Gallium scan, HRCT, bronchoscopy were positive in most cases. Patients were treated with steroid and immunosuppressive therapy, with improvement in six cases. One patient died from infectious complications. Conclusion: A definite diagnosis of NS requires demonstration of non–caseating granulomas affecting nervous tissues. In most cases, histological evidence of systemic disease (probable NS) is sufficient in the presence of compatible alterations in the CNS. In our patients the bronchoalveolarlavage fluid analysis, gallium scan, and chest HRCT were important for diagnosis,while serum ACE was always normal and chest radiographs were not suggestive of sarcoidosis.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>neurosarcoidosis</term></item><item><term>CNS diseases</term></item><item><term>inflammatory</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Neurosciences</term></item><item><term>Neuroradiology</term></item><item><term>Neurology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-02-28">Created</change><change when="2006-04-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-P8DDP605-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Steinkopff-Verlag</PublisherName><PublisherLocation>Darmstadt</PublisherLocation></PublisherInfo><Journal OutputMedium="All"><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>415</JournalID><JournalPrintISSN>0340-5354</JournalPrintISSN><JournalElectronicISSN>1432-1459</JournalElectronicISSN><JournalTitle>Journal of Neurology</JournalTitle><JournalAbbreviatedTitle>J Neurol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Neurosciences</JournalSubject><JournalSubject Type="Secondary">Neuroradiology</JournalSubject><JournalSubject Type="Secondary">Neurology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>253</VolumeIDStart><VolumeIDEnd>253</VolumeIDEnd><VolumeIssueCount>12</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd><IssueArticleCount>28</IssueArticleCount><IssueHistory><CoverDate><Year>2006</Year><Month>4</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Steinkopff-Verlag</CopyrightHolderName><CopyrightYear>2006</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art1" OutputMedium="All"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>43</ArticleID><ArticleDOI>10.1007/s00415-005-0043-5</ArticleDOI><ArticleSequenceNumber>12</ArticleSequenceNumber><ArticleTitle Language="En">Neurosarcoidosis</ArticleTitle><ArticleSubTitle Language="En">Clinical description of 7 cases with a proposal for a new diagnostic strategy</ArticleSubTitle><ArticleCategory>ORIGINAL COMMUNICATION</ArticleCategory>
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<ArticleLastPage>495</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>1</Month><Day>1</Day></RegistrationDate><Received><Year>2005</Year><Month>2</Month><Day>28</Day></Received><Revised><Year>2005</Year><Month>9</Month><Day>5</Day></Revised><Accepted><Year>2005</Year><Month>9</Month><Day>15</Day></Accepted><OnlineDate><Year>2005</Year><Month>11</Month><Day>14</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Steinkopff-Verlag</CopyrightHolderName><CopyrightYear>2006</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><Prefix>Dr. ssa</Prefix><GivenName>S.</GivenName><FamilyName>Marangoni</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><Prefix>Dr. ssa</Prefix><GivenName>V.</GivenName><FamilyName>Argentiero</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><Prefix>Prof.</Prefix><GivenName>B.</GivenName><FamilyName>Tavolato</FamilyName></AuthorName><Contact><Phone>+34-49/8215317</Phone><Fax>+34-49/8215316</Fax><Email>bruno.tavolato@unipd.it</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Clinica Neurologica II</OrgDivision><OrgName>Ospedale S.Antonio</OrgName><OrgAddress><Street>Via Facciolati 71</Street><Postcode>35127</Postcode><City>Padova</City><Country Code="IT">Italy
</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><AbstractSection ID="AbsSec1"><Heading><Emphasis Type="Italic">Objective</Emphasis></Heading><Para>Chronic involvement of the nervous system is relatively rare in sarcoidosis. We describe 7 cases that fulfil Zajicek's criteria for neurosarcoidosis (NS) and propose some modifications to such criteria.</Para></AbstractSection>
<AbstractSection ID="AbsSec2"><Heading><Emphasis Type="Italic">Materials and methods</Emphasis></Heading><Para>The patients were admitted for various neurological syndromes: 2 cases presented with chronic lymphocytic meningitis, 4 with spinal cord symptoms, one case was initially confused with multiple sclerosis. Serological tests, immunological screening, cerebrospinal fluid (CSF) analysis, bacteriological and viral testing were performed in all patients. Spinal and cerebral MRI, gallium scan, bronchoscopy with biopsy and bronchoalveolar–lavage fluid analysis, high–resolution computed tomography (HRCT) of the chest, biopsy of the lungs, skin, mediastinal lymph–node and meninges, were useful in diagnosing NS.</Para></AbstractSection><AbstractSection ID="AbsSec3"><Heading><Emphasis Type="Italic">Results and discussion</Emphasis></Heading><Para>Laboratory tests showed serum inflammatory abnormalities, but were negative for infectious diseases, while CSF showed inflammatory signs in all patients. MRI revealed meningeal enhancement or hypertrophic pachymeningeal lesions in 4 patients, white matter abnormalities and mass lesions in 2 patients, and a spinal mass lesion in 1 patient. Gallium scan, HRCT, bronchoscopy were positive in most cases. Patients were treated with steroid and immunosuppressive therapy, with improvement in six cases. One patient died from infectious complications.</Para></AbstractSection><AbstractSection ID="AbsSec4"><Heading><Emphasis Type="Italic">Conclusion</Emphasis></Heading><Para>A definite diagnosis of NS requires demonstration of non–caseating granulomas affecting nervous tissues. In most cases, histological evidence of systemic disease (probable NS) is sufficient in the presence of compatible alterations in the CNS. In our patients the bronchoalveolarlavage fluid analysis, gallium scan, and chest HRCT were important for diagnosis,while serum ACE was always normal and chest radiographs were not suggestive of sarcoidosis.</Para></AbstractSection></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>neurosarcoidosis</Keyword><Keyword>CNS diseases</Keyword><Keyword>inflammatory</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Neurosarcoidosis</title><subTitle>Clinical description of 7 cases with a proposal for a new diagnostic strategy</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Neurosarcoidosis</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr. ssa</namePart><namePart type="given">S.</namePart><namePart type="family">Marangoni</namePart><affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr. ssa</namePart><namePart type="given">V.</namePart><namePart type="family">Argentiero</namePart><affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="termsOfAddress">Prof.</namePart><namePart type="given">B.</namePart><namePart type="family">Tavolato</namePart><affiliation>Clinica Neurologica II, Ospedale S.Antonio, Via Facciolati 71, 35127, Padova, Italy</affiliation><affiliation>E-mail: bruno.tavolato@unipd.it</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Steinkopff-Verlag</publisher><place><placeTerm type="text">Darmstadt</placeTerm></place><dateCreated encoding="w3cdtf">2005-02-28</dateCreated><dateIssued encoding="w3cdtf">2006-04-01</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Objective: Chronic involvement of the nervous system is relatively rare in sarcoidosis. We describe 7 cases that fulfil Zajicek's criteria for neurosarcoidosis (NS) and propose some modifications to such criteria. Materials and methods: The patients were admitted for various neurological syndromes: 2 cases presented with chronic lymphocytic meningitis, 4 with spinal cord symptoms, one case was initially confused with multiple sclerosis. Serological tests, immunological screening, cerebrospinal fluid (CSF) analysis, bacteriological and viral testing were performed in all patients. Spinal and cerebral MRI, gallium scan, bronchoscopy with biopsy and bronchoalveolar–lavage fluid analysis, high–resolution computed tomography (HRCT) of the chest, biopsy of the lungs, skin, mediastinal lymph–node and meninges, were useful in diagnosing NS. Results and discussion: Laboratory tests showed serum inflammatory abnormalities, but were negative for infectious diseases, while CSF showed inflammatory signs in all patients. MRI revealed meningeal enhancement or hypertrophic pachymeningeal lesions in 4 patients, white matter abnormalities and mass lesions in 2 patients, and a spinal mass lesion in 1 patient. Gallium scan, HRCT, bronchoscopy were positive in most cases. Patients were treated with steroid and immunosuppressive therapy, with improvement in six cases. One patient died from infectious complications. Conclusion: A definite diagnosis of NS requires demonstration of non–caseating granulomas affecting nervous tissues. In most cases, histological evidence of systemic disease (probable NS) is sufficient in the presence of compatible alterations in the CNS. In our patients the bronchoalveolarlavage fluid analysis, gallium scan, and chest HRCT were important for diagnosis,while serum ACE was always normal and chest radiographs were not suggestive of sarcoidosis.</abstract><note>ORIGINAL COMMUNICATION</note><subject lang="en"><genre>Key words</genre><topic>neurosarcoidosis</topic><topic>CNS diseases</topic><topic>inflammatory</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2006-04-01</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Neurosciences</topic><topic>Neuroradiology</topic><topic>Neurology</topic></subject><identifier type="ISSN">0340-5354</identifier><identifier type="eISSN">1432-1459</identifier><identifier type="JournalID">415</identifier><identifier type="IssueArticleCount">28</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2006</date><detail type="volume"><number>253</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>488</start><end>495</end></extent></part><recordInfo><recordOrigin>Steinkopff-Verlag, 2006</recordOrigin></recordInfo></relatedItem><identifier type="istex">58EED0CB97350EA1A47B683F52DEA473E4825858</identifier><identifier type="ark">ark:/67375/VQC-P8DDP605-Q</identifier><identifier type="DOI">10.1007/s00415-005-0043-5</identifier><identifier type="ArticleID">43</identifier><identifier type="ArticleID">Art1</identifier><accessCondition type="use and reproduction" contentType="copyright">Steinkopff-Verlag, 2006</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Steinkopff-Verlag, 2006</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-P8DDP605-Q/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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