ChloroquineV1, Hal, Checkpoint, bibRecord, 000146

New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.

Identifieur interne : 000146 ( Hal/Checkpoint ); précédent : 000145; suivant : 000147

New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.

Auteurs : Luke Mani ; Valerie Jullian ; Beatrice Mourkazel ; Alexis Valentin ; Joëlle Dubois [France] ; Thierry Cresteil [France] ; Eric Folcher ; John N A. Hooper ; Dirk Erpenbeck ; William Aalbersberg ; Cécile Debitus

Source :

Chemistry and Biodiversity [ 1612-1872 ] ; 2012-08.

RBID : Hal:hal-00745061

Abstract

Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.

Url:

https://hal.archives-ouvertes.fr/hal-00745061

DOI: 10.1002/cbdv.201100309

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Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.</p>
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New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.

New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.

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Abstract

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