New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.
Identifieur interne : 000172 ( Hal/Curation ); précédent : 000171; suivant : 000173New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.
Auteurs : Luke Mani ; Valerie Jullian ; Beatrice Mourkazel ; Alexis Valentin ; Joëlle Dubois [France] ; Thierry Cresteil [France] ; Eric Folcher ; John N A. Hooper ; Dirk Erpenbeck ; William Aalbersberg ; Cécile DebitusSource :
- Chemistry and Biodiversity [ 1612-1872 ] ; 2012-08.
Abstract
Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.
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DOI: 10.1002/cbdv.201100309
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<front><div type="abstract" xml:lang="en"> <p>Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.</p>
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