Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
Identifieur interne : 000022 ( France/Extraction ); précédent : 000021; suivant : 000023Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
Auteurs : Laure Ricard [France] ; Vincent Jachiet [France] ; Florent Malard [France] ; Yishan Ye ; Nicolas Stocker ; Sébastien Rivière [France] ; Patricia Senet [France] ; Jean-Benoit Monfort [États-Unis] ; Olivier Fain [France] ; Mohamad Mohty [France] ; Béatrice Gaugler [France] ; Arsène Mékinian [France]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2019.
Abstract
Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.
Url:
DOI: 10.1136/annrheumdis-2018-214382
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000052
- to stream Hal, to step Curation: 000052
- to stream Hal, to step Checkpoint: 000019
- to stream Main, to step Merge: 000250
- to stream Main, to step Curation: 000250
- to stream Main, to step Exploration: 000250
Links to Exploration step
Hal:hal-02178935Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib</title>
<author><name sortKey="Ricard, Laure" sort="Ricard, Laure" uniqKey="Ricard L" first="Laure" last="Ricard">Laure Ricard</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jachiet, Vincent" sort="Jachiet, Vincent" uniqKey="Jachiet V" first="Vincent" last="Jachiet">Vincent Jachiet</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName>
<orgName type="acronym">DHU i2B </orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-454982" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Malard, Florent" sort="Malard, Florent" uniqKey="Malard F" first="Florent" last="Malard">Florent Malard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-81446" status="OLD"> <idno type="RNSR">200918542V</idno>
<orgName>Centre de Recherche Saint-Antoine</orgName>
<orgName type="acronym">CR Saint-Antoine</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation>
<relation active="#struct-93591" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ye, Yishan" sort="Ye, Yishan" uniqKey="Ye Y" first="Yishan" last="Ye">Yishan Ye</name>
</author>
<author><name sortKey="Stocker, Nicolas" sort="Stocker, Nicolas" uniqKey="Stocker N" first="Nicolas" last="Stocker">Nicolas Stocker</name>
</author>
<author><name sortKey="Riviere, Sebastien" sort="Riviere, Sebastien" uniqKey="Riviere S" first="Sébastien" last="Rivière">Sébastien Rivière</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName>
<orgName type="acronym">DHU i2B </orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-454982" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-328304" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-66086" status="VALID"> <orgName>Department of Civil and Environmental Engineering [Durham]</orgName>
<orgName type="acronym">CEE</orgName>
<desc> <address> <addrLine>Room 121 Hudson Hall, Box 90287, Durham, NC 27708-0287</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://www.cee.duke.edu/</ref>
</desc>
<listRelation> <relation active="#struct-95351" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-95351" type="direct"><org type="institution" xml:id="struct-95351" status="VALID"> <idno type="ISNI">0000 0004 1936 7961</idno>
<orgName>Duke University [Durham]</orgName>
<desc> <address> <addrLine>Durham, NC 27708</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://www.duke.edu/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-493499" status="VALID"> <orgName>Service de Médecine Interne [CHU Saint-Antoine]</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-454982" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-81446" status="OLD"> <idno type="RNSR">200918542V</idno>
<orgName>Centre de Recherche Saint-Antoine</orgName>
<orgName type="acronym">CR Saint-Antoine</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation>
<relation active="#struct-93591" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182215" status="VALID"> <idno type="IdRef">166218421</idno>
<orgName>Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)</orgName>
<orgName type="acronym">HOTE GREFFON</orgName>
<desc> <address> <addrLine>I.B.C.T. Bâtiment Inserm 240 Route de Dole/Rue F. Dolto 25000 Besançon</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-fcomte.fr/pages/fr/menu1/recherche/la-recherche-a-l-ufc/umr-1098---relation-hote-greffon-18229-8143.html</ref>
</desc>
<listRelation> <relation name="U1098" active="#struct-303623" type="direct"></relation>
<relation active="#struct-439502" type="direct"></relation>
<relation active="#struct-458810" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="U1098" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-439502" type="direct"><org type="institution" xml:id="struct-439502" status="VALID"> <orgName>Etablissement français du sang [Bourgogne-France-Comté] </orgName>
<orgName type="acronym">EFS [Bourgogne-France-Comté]</orgName>
<desc> <address> <addrLine>1 Boulevard Fleming 25020 Besançon cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dondusang.net</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-458810" type="direct"><org type="institution" xml:id="struct-458810" status="VALID"> <idno type="IdRef">026403188</idno>
<idno type="ISNI">0000 0001 2188 3779 </idno>
<orgName>Université de Franche-Comté</orgName>
<orgName type="acronym">UFC</orgName>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.univ-fcomte.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city" wicri:auto="siege">Besançon</settlement>
<region type="region" nuts="2">Franche-Comté</region>
</placeName>
<orgName type="university">Université de Franche-Comté</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Bourgogne Franche-Comté</orgName>
</affiliation>
</author>
<author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName>
<orgName type="acronym">SU</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.sorbonne-universite.fr/</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-02178935</idno>
<idno type="halId">hal-02178935</idno>
<idno type="halUri">https://hal.sorbonne-universite.fr/hal-02178935</idno>
<idno type="url">https://hal.sorbonne-universite.fr/hal-02178935</idno>
<idno type="doi">10.1136/annrheumdis-2018-214382</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Hal/Corpus">000052</idno>
<idno type="wicri:Area/Hal/Curation">000052</idno>
<idno type="wicri:Area/Hal/Checkpoint">000019</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000019</idno>
<idno type="wicri:doubleKey">0003-4967:2019:Ricard L:circulating:follicular:helper</idno>
<idno type="wicri:Area/Main/Merge">000250</idno>
<idno type="wicri:Area/Main/Curation">000250</idno>
<idno type="wicri:Area/Main/Exploration">000250</idno>
<idno type="wicri:Area/France/Extraction">000022</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib</title>
<author><name sortKey="Ricard, Laure" sort="Ricard, Laure" uniqKey="Ricard L" first="Laure" last="Ricard">Laure Ricard</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jachiet, Vincent" sort="Jachiet, Vincent" uniqKey="Jachiet V" first="Vincent" last="Jachiet">Vincent Jachiet</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName>
<orgName type="acronym">DHU i2B </orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-454982" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Malard, Florent" sort="Malard, Florent" uniqKey="Malard F" first="Florent" last="Malard">Florent Malard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-81446" status="OLD"> <idno type="RNSR">200918542V</idno>
<orgName>Centre de Recherche Saint-Antoine</orgName>
<orgName type="acronym">CR Saint-Antoine</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation>
<relation active="#struct-93591" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ye, Yishan" sort="Ye, Yishan" uniqKey="Ye Y" first="Yishan" last="Ye">Yishan Ye</name>
</author>
<author><name sortKey="Stocker, Nicolas" sort="Stocker, Nicolas" uniqKey="Stocker N" first="Nicolas" last="Stocker">Nicolas Stocker</name>
</author>
<author><name sortKey="Riviere, Sebastien" sort="Riviere, Sebastien" uniqKey="Riviere S" first="Sébastien" last="Rivière">Sébastien Rivière</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName>
<orgName type="acronym">DHU i2B </orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-454982" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID"> <orgName>Service de Dermatologie [CHU Tenon]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-328304" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName>
<desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-66086" status="VALID"> <orgName>Department of Civil and Environmental Engineering [Durham]</orgName>
<orgName type="acronym">CEE</orgName>
<desc> <address> <addrLine>Room 121 Hudson Hall, Box 90287, Durham, NC 27708-0287</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://www.cee.duke.edu/</ref>
</desc>
<listRelation> <relation active="#struct-95351" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-95351" type="direct"><org type="institution" xml:id="struct-95351" status="VALID"> <idno type="ISNI">0000 0004 1936 7961</idno>
<orgName>Duke University [Durham]</orgName>
<desc> <address> <addrLine>Durham, NC 27708</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://www.duke.edu/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-493499" status="VALID"> <orgName>Service de Médecine Interne [CHU Saint-Antoine]</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-454982" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="acronym">APHP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName>
<desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-81446" status="OLD"> <idno type="RNSR">200918542V</idno>
<orgName>Centre de Recherche Saint-Antoine</orgName>
<orgName type="acronym">CR Saint-Antoine</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation>
<relation active="#struct-93591" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182215" status="VALID"> <idno type="IdRef">166218421</idno>
<orgName>Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)</orgName>
<orgName type="acronym">HOTE GREFFON</orgName>
<desc> <address> <addrLine>I.B.C.T. Bâtiment Inserm 240 Route de Dole/Rue F. Dolto 25000 Besançon</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-fcomte.fr/pages/fr/menu1/recherche/la-recherche-a-l-ufc/umr-1098---relation-hote-greffon-18229-8143.html</ref>
</desc>
<listRelation> <relation name="U1098" active="#struct-303623" type="direct"></relation>
<relation active="#struct-439502" type="direct"></relation>
<relation active="#struct-458810" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="U1098" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-439502" type="direct"><org type="institution" xml:id="struct-439502" status="VALID"> <orgName>Etablissement français du sang [Bourgogne-France-Comté] </orgName>
<orgName type="acronym">EFS [Bourgogne-France-Comté]</orgName>
<desc> <address> <addrLine>1 Boulevard Fleming 25020 Besançon cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dondusang.net</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-458810" type="direct"><org type="institution" xml:id="struct-458810" status="VALID"> <idno type="IdRef">026403188</idno>
<idno type="ISNI">0000 0001 2188 3779 </idno>
<orgName>Université de Franche-Comté</orgName>
<orgName type="acronym">UFC</orgName>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.univ-fcomte.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city" wicri:auto="siege">Besançon</settlement>
<region type="region" nuts="2">Franche-Comté</region>
</placeName>
<orgName type="university">Université de Franche-Comté</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Bourgogne Franche-Comté</orgName>
</affiliation>
</author>
<author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName>
<orgName type="acronym">SU</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.sorbonne-universite.fr/</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1136/annrheumdis-2018-214382</idno>
<series><title level="j">Annals of the Rheumatic Diseases</title>
<idno type="ISSN">0003-4967</idno>
<imprint><date type="datePub">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Franche-Comté</li>
</region>
<settlement><li>Besançon</li>
</settlement>
<orgName><li>Université de Bourgogne Franche-Comté</li>
<li>Université de Franche-Comté</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Stocker, Nicolas" sort="Stocker, Nicolas" uniqKey="Stocker N" first="Nicolas" last="Stocker">Nicolas Stocker</name>
<name sortKey="Ye, Yishan" sort="Ye, Yishan" uniqKey="Ye Y" first="Yishan" last="Ye">Yishan Ye</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Ricard, Laure" sort="Ricard, Laure" uniqKey="Ricard L" first="Laure" last="Ricard">Laure Ricard</name>
</noRegion>
<name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
<name sortKey="Jachiet, Vincent" sort="Jachiet, Vincent" uniqKey="Jachiet V" first="Vincent" last="Jachiet">Vincent Jachiet</name>
<name sortKey="Malard, Florent" sort="Malard, Florent" uniqKey="Malard F" first="Florent" last="Malard">Florent Malard</name>
<name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<name sortKey="Riviere, Sebastien" sort="Riviere, Sebastien" uniqKey="Riviere S" first="Sébastien" last="Rivière">Sébastien Rivière</name>
<name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Extraction
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000022 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Extraction/biblio.hfd -nk 000022 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= France |étape= Extraction |type= RBID |clé= Hal:hal-02178935 |texte= Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib }}
This area was generated with Dilib version V0.6.33. |