ChloroquineV1, France, Analysis, bibRecord, 000429

Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages

Identifieur interne : 000429 ( France/Analysis ); précédent : 000428; suivant : 000430

Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages

Auteurs : T. Lazard [France] ; C. Perronne [France] ; C. Truffot-Pernot [France] ; J. Grosset [France] ; J. L. Vildé [France] ; J. J. Pocidalo [France]

Source :

Tubercle and Lung Disease [ 0962-8479 ] ; 1994.

RBID : ISTEX:39FBD52B71A52FBF28E0983A2E250AA41CE52942

Descripteurs français

KwdFr :
- Cellules cultivées, Chloroquine (pharmacologie), Clarithromycine (pharmacologie), Humains, Interactions médicamenteuses, Macrophages (microbiologie), Mycobacterium avium (), Mycobacterium avium (croissance et développement), Numération de colonies microbiennes.
MESH :
- croissance et développement : Mycobacterium avium.
- microbiologie : Macrophages.
- pharmacologie : Chloroquine, Clarithromycine.
- Cellules cultivées, Humains, Interactions médicamenteuses, Mycobacterium avium, Numération de colonies microbiennes.

English descriptors

KwdEn :
- Cells, Cultured, Chloroquine (pharmacology), Clarithromycin (pharmacology), Colony Count, Microbial, Drug Interactions, Humans, Macrophages (microbiology), Mycobacterium avium (drug effects), Mycobacterium avium (growth & development).
MESH :
- chemical , pharmacology : Chloroquine, Clarithromycin.
- drug effects : Mycobacterium avium.
- growth & development : Mycobacterium avium.
- microbiology : Macrophages.
Teeft :
- Acidic, Actividad, Antibiotic, Antimicrob, Antimicrob agents chemother, Avium, Avium infection, Bacterial suspension, Cells, Cultured, Chemother, Chloroquine, Clarithromycin, Clarithromycine, Claritromicina, Cloroquina, Colony Count, Microbial, Contra, Coxiella, Crowle, Difco, Drug Interactions, Extracellular, Extracellular bacteria, Grosset, Human macrophages, Humans, Intracellular, Macrophage, Mycobacterium, Perronne, Pocidalo, Rpm1, Streptomycin, Supematant, Tubercle.

Abstract

Abstract: Setting: Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.Objective: To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium.Design: The activity of clarithromycin (4 μg/ml) against the MO-1 strain of M. avium was evaluated within human macrophages in presence of chloroquine (5 μg/ml). The minimal inhibitory concentration of clarithromycin for the strain was 2 μg/ml.Results: While clarithromycin alone did decrease the intracellular infection at day 7 of culture (P < 0.01), chloroquine alone did not impede the intracellular growth of M. avium, and did not enhance the activity of clarithromycin.Conclusion: Chloroquine should not improve clarithromycin treatment against M. avium infection.

Résumé: Cadre: La chloroquine, agent alcalinisant lysosomotrope, augmente l'activité des antibiotiques contre Mycobacterium tuberculosis ou Coxiella burnetii.Objet: Déterminer si la chloroquine modifie l'activité de la clarithromycine, moins active à pH acide, contre Mycobacterium avium intracellulaire.Schéma: L'activité de la clarithromycine (4 μg/ml) contre la souche MO-1 de M. avium a été évaluée dans des macrophages humains en présence de chloroquine (5 μg/ml). La concentration minimale inhibitrice de la clarithromycine pour la souche était de 2 μg/ml.Résultats: Tandis que la clarithromycine seule a diminué l'infection intracellulaire au jour 7 de culture (P < 0,01), la chloroquine seule n'a pas empêché la croissance intracellulaire de M. avium, et n'a pas augmenté l'activité de la clarithromycine.Conclusion: La chloroquine ne renforce pas le traitement par clarithromycine de l'infection à M. avium.

Resumen: Marco de referencia: La cloroquina, agente alcalinizante lisosomotrópico, estimula la actividad intracelular de los antibióticos contra Mycobacterium tuberculosis o Coxiella burnetii.Objetivo: Determinar si la cloroquina modifica la actividad de la claritromicina, menos activa en pH ácido, contra Mycobacterium avium.Método: Se evaluó la actividad de la claritromicina (4 μg/ml) contra la cepa MO-1 de M. avium en macrófagos humanos en presencia de cloroquina (5 μg/ml). La concentración inhibidora mínima de la claritromicina para la cepa era de 2 (μg/ml.Resultados: Mientras que la claritromicina sola disminuía la infección intracelular al día 7 de cultivo (P < 0,01), la cloroquina sola no impedía el crecimiento intracellular de M. avium y no estimulaba la actividad de la claritromicina.Conclusión: La cloroquina no mejoraría la eficacia del tratamiento con claritromicina contra la infección M. avium.

Url:

https://api.istex.fr/ark:/67375/6H6-PL5XKGL2-B/fulltext.pdf

DOI: 10.1016/0962-8479(94)90133-3

Affiliations:

Links to Exploration step

ISTEX:39FBD52B71A52FBF28E0983A2E250AA41CE52942

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cells, Cultured</term>
<term>Chloroquine (pharmacology)</term>
<term>Clarithromycin (pharmacology)</term>
<term>Colony Count, Microbial</term>
<term>Drug Interactions</term>
<term>Humans</term>
<term>Macrophages (microbiology)</term>
<term>Mycobacterium avium (drug effects)</term>
<term>Mycobacterium avium (growth & development)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Cellules cultivées</term>
<term>Chloroquine (pharmacologie)</term>
<term>Clarithromycine (pharmacologie)</term>
<term>Humains</term>
<term>Interactions médicamenteuses</term>
<term>Macrophages (microbiologie)</term>
<term>Mycobacterium avium ()</term>
<term>Mycobacterium avium (croissance et développement)</term>
<term>Numération de colonies microbiennes</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term>
<term>Clarithromycin</term>
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<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Mycobacterium avium</term>
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<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Mycobacterium avium</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Macrophages</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term>
<term>Clarithromycine</term>
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<term>Actividad</term>
<term>Antibiotic</term>
<term>Antimicrob</term>
<term>Antimicrob agents chemother</term>
<term>Avium</term>
<term>Avium infection</term>
<term>Bacterial suspension</term>
<term>Cells, Cultured</term>
<term>Chemother</term>
<term>Chloroquine</term>
<term>Clarithromycin</term>
<term>Clarithromycine</term>
<term>Claritromicina</term>
<term>Cloroquina</term>
<term>Colony Count, Microbial</term>
<term>Contra</term>
<term>Coxiella</term>
<term>Crowle</term>
<term>Difco</term>
<term>Drug Interactions</term>
<term>Extracellular</term>
<term>Extracellular bacteria</term>
<term>Grosset</term>
<term>Human macrophages</term>
<term>Humans</term>
<term>Intracellular</term>
<term>Macrophage</term>
<term>Mycobacterium</term>
<term>Perronne</term>
<term>Pocidalo</term>
<term>Rpm1</term>
<term>Streptomycin</term>
<term>Supematant</term>
<term>Tubercle</term>
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<term>Humains</term>
<term>Interactions médicamenteuses</term>
<term>Mycobacterium avium</term>
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<front><div type="abstract" xml:lang="en">Abstract: Setting: Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.Objective: To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium.Design: The activity of clarithromycin (4 μg/ml) against the MO-1 strain of M. avium was evaluated within human macrophages in presence of chloroquine (5 μg/ml). The minimal inhibitory concentration of clarithromycin for the strain was 2 μg/ml.Results: While clarithromycin alone did decrease the intracellular infection at day 7 of culture (P < 0.01), chloroquine alone did not impede the intracellular growth of M. avium, and did not enhance the activity of clarithromycin.Conclusion: Chloroquine should not improve clarithromycin treatment against M. avium infection.</div>
<div type="abstract" xml:lang="fr">Résumé: Cadre: La chloroquine, agent alcalinisant lysosomotrope, augmente l'activité des antibiotiques contre Mycobacterium tuberculosis ou Coxiella burnetii.Objet: Déterminer si la chloroquine modifie l'activité de la clarithromycine, moins active à pH acide, contre Mycobacterium avium intracellulaire.Schéma: L'activité de la clarithromycine (4 μg/ml) contre la souche MO-1 de M. avium a été évaluée dans des macrophages humains en présence de chloroquine (5 μg/ml). La concentration minimale inhibitrice de la clarithromycine pour la souche était de 2 μg/ml.Résultats: Tandis que la clarithromycine seule a diminué l'infection intracellulaire au jour 7 de culture (P < 0,01), la chloroquine seule n'a pas empêché la croissance intracellulaire de M. avium, et n'a pas augmenté l'activité de la clarithromycine.Conclusion: La chloroquine ne renforce pas le traitement par clarithromycine de l'infection à M. avium.</div>
<div type="abstract" xml:lang="es">Resumen: Marco de referencia: La cloroquina, agente alcalinizante lisosomotrópico, estimula la actividad intracelular de los antibióticos contra Mycobacterium tuberculosis o Coxiella burnetii.Objetivo: Determinar si la cloroquina modifica la actividad de la claritromicina, menos activa en pH ácido, contra Mycobacterium avium.Método: Se evaluó la actividad de la claritromicina (4 μg/ml) contra la cepa MO-1 de M. avium en macrófagos humanos en presencia de cloroquina (5 μg/ml). La concentración inhibidora mínima de la claritromicina para la cepa era de 2 (μg/ml.Resultados: Mientras que la claritromicina sola disminuía la infección intracelular al día 7 de cultivo (P < 0,01), la cloroquina sola no impedía el crecimiento intracellular de M. avium y no estimulaba la actividad de la claritromicina.Conclusión: La cloroquina no mejoraría la eficacia del tratamiento con claritromicina contra la infección M. avium.</div>
</front>
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<name sortKey="Vilde, J L" sort="Vilde, J L" uniqKey="Vilde J" first="J. L." last="Vildé">J. L. Vildé</name>
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Serveur d'exploration Chloroquine

Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages

Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages

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Descripteurs français

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Abstract

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