The antimalarial ferroquine: from bench to clinic.
Identifieur interne : 000236 ( France/Analysis ); précédent : 000235; suivant : 000237The antimalarial ferroquine: from bench to clinic.
Auteurs : Christophe Biot [France] ; F. Nosten [Royaume-Uni] ; L. Fraisse [France] ; D. Ter-Minassian [France] ; Jamal Khalife [France] ; Daniel Dive [France]Source :
- Parasite [ 1252-607X ] ; 2011.
Descripteurs français
- mix :
English descriptors
Abstract
Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.
Url:
DOI: 10.1051/parasite/2011183207
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream France, to step Extraction: 000236
Links to Exploration step
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<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
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<country>France</country>
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</analytic>
<idno type="DOI">10.1051/parasite/2011183207</idno>
<series><title level="j">Parasite</title>
<idno type="ISSN">1252-607X</idno>
<imprint><date type="datePub">2011</date>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>bioorganometallics</term>
<term>drug candidate</term>
<term>ferroquine</term>
<term>malaria</term>
<term>mechanism of action</term>
<term>resistance</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>bio-organométallique</term>
<term>candidat médicament</term>
<term>ferroquine</term>
<term>mécanisme d’action</term>
<term>paludisme</term>
<term>résistance</term>
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<front><div type="abstract" xml:lang="en"> <p>Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Royaume-Uni</li>
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<tree><country name="France"><noRegion><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
</noRegion>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Fraisse, L" sort="Fraisse, L" uniqKey="Fraisse L" first="L." last="Fraisse">L. Fraisse</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<name sortKey="Ter Minassian, D" sort="Ter Minassian, D" uniqKey="Ter Minassian D" first="D." last="Ter-Minassian">D. Ter-Minassian</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Nosten, F" sort="Nosten, F" uniqKey="Nosten F" first="F." last="Nosten">F. Nosten</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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