ChloroquineV1, Hal, Checkpoint, bibRecord, 000170

The antimalarial ferroquine: from bench to clinic.

Identifieur interne : 000170 ( Hal/Checkpoint ); précédent : 000169; suivant : 000171

The antimalarial ferroquine: from bench to clinic.

Auteurs : Christophe Biot [France] ; F. Nosten [Royaume-Uni] ; L. Fraisse [France] ; D. Ter-Minassian [France] ; Jamal Khalife [France] ; Daniel Dive [France]

Source :

Parasite [ 1252-607X ] ; 2011.

RBID : Hal:hal-00642112

Descripteurs français

mix :
- bio-organométallique, candidat médicament, ferroquine, mécanisme d’action, paludisme, résistance.

English descriptors

mix :
- bioorganometallics, drug candidate, ferroquine, malaria, mechanism of action, resistance.

Abstract

Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.

Url:

https://hal.archives-ouvertes.fr/hal-00642112

DOI: 10.1051/parasite/2011183207

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000237
to stream Hal, to step Curation: 000237

Links to Exploration step

Hal:hal-00642112

Le document en format XML

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<idno type="DOI">10.1051/parasite/2011183207</idno>
<series><title level="j">Parasite</title>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>bioorganometallics</term>
<term>drug candidate</term>
<term>ferroquine</term>
<term>malaria</term>
<term>mechanism of action</term>
<term>resistance</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>bio-organométallique</term>
<term>candidat médicament</term>
<term>ferroquine</term>
<term>mécanisme d’action</term>
<term>paludisme</term>
<term>résistance</term>
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<front><div type="abstract" xml:lang="en">              <p>Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.</p>
            </div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">The antimalarial ferroquine: from bench to clinic.</title>
            <title xml:lang="fr">L’activité antipaludique de la ferroquine : de la recherche à la clinique</title>
            <author role="crp">              <persName>                <forename type="first">Christophe</forename>
                <surname>Biot</surname>
              </persName>
              <email type="md5">abe2ae0786be9d232a0f47c7ebc527ea</email>
              <email type="domain">univ-lille1.fr</email>
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            <author role="aut">              <persName>                <forename type="first">F.</forename>
                <surname>Nosten</surname>
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            <author role="aut">              <persName>                <forename type="first">L.</forename>
                <surname>Fraisse</surname>
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              <idno type="halauthorid">55501</idno>
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            <author role="aut">              <persName>                <forename type="first">D.</forename>
                <surname>Ter-Minassian</surname>
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            </author>
            <author role="aut">              <persName>                <forename type="first">Jamal</forename>
                <surname>Khalife</surname>
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              <email type="md5">167ebf82d12378fac020b67e81f6a6bf</email>
              <email type="domain">pasteur-lille.fr</email>
              <idno type="halauthorid">207769</idno>
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            <author role="aut">              <persName>                <forename type="first">Daniel</forename>
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            <editor role="depositor">              <persName>                <forename>Xavier</forename>
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              <email type="md5">d10f7469116c076cad67315641c7b701</email>
              <email type="domain">univ-lille1.fr</email>
            </editor>
            <funder>We acknowledge scientists who collaborated in the research: B. Pradines, T. Egan, K. Chibale, C. Slomianny, X. Trivelli, S. Bohic, E. Curis, and I. Forfar. F. Nosten is supported by the Wellcome Trust of Great Britain. We thank Ministère de l’Enseignement Supérieur, Université Lille Nord de France, CNRS and INSERM.</funder>
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          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2019-09-16 11:52:36</date>
              <date type="whenModified">2019-09-17 15:35:15</date>
              <date type="whenReleased">2019-09-17 15:35:15</date>
              <date type="whenProduced">2011</date>
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          <seriesStmt>            <idno type="stamp" n="RIIP_LILLE">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="UNIV-ARTOIS">Université d'Artois</idno>
            <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="EC-LILLE">Ecole Centrale de Lille</idno>
            <idno type="stamp" n="ENSC-LILLE">Ecole Nationale Supérieure de Chimie de Lille</idno>
            <idno type="stamp" n="UCCS">Unité de Catalyse et de Chimie du Solide</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
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          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">The antimalarial ferroquine: from bench to clinic.</title>
                <title xml:lang="fr">L’activité antipaludique de la ferroquine : de la recherche à la clinique</title>
                <author role="crp">                  <persName>                    <forename type="first">Christophe</forename>
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                <author role="aut">                  <persName>                    <forename type="first">Daniel</forename>
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                  <date type="datePub">2011</date>
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              <idno type="doi">10.1051/parasite/2011183207</idno>
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            <textClass>              <keywords scheme="author">                <term xml:lang="en">resistance</term>
                <term xml:lang="en">mechanism of action</term>
                <term xml:lang="en">ferroquine</term>
                <term xml:lang="en">drug candidate</term>
                <term xml:lang="en">bioorganometallics</term>
                <term xml:lang="en">malaria</term>
                <term xml:lang="fr">résistance</term>
                <term xml:lang="fr">mécanisme d’action</term>
                <term xml:lang="fr">ferroquine</term>
                <term xml:lang="fr">candidat médicament</term>
                <term xml:lang="fr">bio-organométallique</term>
                <term xml:lang="fr">paludisme</term>
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              <classCode scheme="mesh">Aminoquinolines/chemistry</classCode>
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              <classCode scheme="mesh">Ferrous Compounds/therapeutic use*</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Malaria, Falciparum/drug therapy*</classCode>
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            <abstract xml:lang="en">              <p>Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.</p>
            </abstract>
            <abstract xml:lang="fr">              <p>La ferroquine (FQ, SSR97193) est actuellement le candidat médicament organométallique le plus avancé dans son développement industriel et, en tant que traitement du paludisme non compliqué, il devrait bientôt voir s’achever des études cliniques de phase II. Ce composé à base de ferrocène est extrêmement actif contre des isolats et/ou des clones de Plasmodium falciparum et de P. vivax sensibles ou résistants à la chloroquine. Cet article présente la découverte de la FQ, son activité antipaludique, les hypothèses liées à son mode d’action, l’absence actuelle de résistance in vitro et, enfin, les récents essais cliniques.</p>
            </abstract>
            <particDesc>              <org type="consortium">All searches on FQ carried out in laboratories * and ***** were funded by Pierre Fabre Médicament and Sanofi-Aventis. The two labs are very grateful to all Ph.D. students who participated to this work (L. Delhaës, H. Abessolo, W. Daher, N. Chavain, and F. Dubar) and provided an excellent work.</org>
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The antimalarial ferroquine: from bench to clinic.

The antimalarial ferroquine: from bench to clinic.

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