Emotional hyper-reactivity in normothymic bipolar patients.
Identifieur interne : 001985 ( Main/Exploration ); précédent : 001984; suivant : 001986Emotional hyper-reactivity in normothymic bipolar patients.
Auteurs : Katia M'Bailara [France] ; Jacques Demotes-Mainard ; Joël Swendsen ; Flavie Mathieu ; Marion Leboyer ; Chantal HenrySource :
- Bipolar disorders [ 1399-5618 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Clignement (MeSH), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Réflexe de sursaut (physiologie), Sujet âgé (MeSH), Symptômes affectifs (étiologie), Trouble bipolaire (complications), Trouble bipolaire (psychologie), Trouble dysthymique (MeSH), Échelles d'évaluation en psychiatrie (MeSH), Émotions (physiologie), Éveil (physiologie).
- MESH :
- physiologie : Réflexe de sursaut, Émotions, Éveil.
- psychologie : Trouble bipolaire.
- étiologie : Symptômes affectifs.
- complications : Adulte, Adulte d'âge moyen, Clignement, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Trouble bipolaire, Trouble dysthymique, Échelles d'évaluation en psychiatrie.
English descriptors
- KwdEn :
- Adult (MeSH), Affective Symptoms (etiology), Aged (MeSH), Arousal (physiology), Bipolar Disorder (complications), Bipolar Disorder (psychology), Blinking (MeSH), Dysthymic Disorder (MeSH), Emotions (physiology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Psychiatric Status Rating Scales (MeSH), Reflex, Startle (physiology), Young Adult (MeSH).
- MESH :
- complications : Bipolar Disorder.
- etiology : Affective Symptoms.
- physiology : Arousal, Emotions, Reflex, Startle.
- psychology : Bipolar Disorder.
- Adult, Aged, Blinking, Dysthymic Disorder, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Young Adult.
Abstract
BACKGROUND
Normothymic states in bipolar disorders are generally considered to be devoid of severe symptoms. However, bipolar patients present subsyndromal symptoms for half of their lives, and often have comorbid psychiatric disorders. If we go beyond the concept of temperamental features, can we identify certain emotional characteristics distinguishing normothymic bipolar patients from normal controls? We previously showed, using self-completed questionnaires, that normothymic bipolar patients display higher levels of emotional lability and intensity than controls.
OBJECTIVES
The aim of this study was to assess the emotional reactivity of normothymic bipolar patients, comparing such patients with a normal control group during an experimental mood induction procedure.
METHOD
We evaluated the subjective emotional reactivity of 145 subjects (90 control subjects and 55 normothymic bipolar patients), using an emotional induction method based on the viewing of a set of 18 pictures (6 positive, 6 negative, 6 neutral) extracted from the International Affective Picture System. Subjective valence and arousal were recorded with the Self-Assessment Manikin. We also recorded startle reflexes, triggered by a tone occurring during the viewing of two-thirds of the pictures. We controlled for confounding factors, such as concurrent treatments, in all analyses.
RESULTS
Normothymic bipolar patients and normal controls assessed valence and arousal similarly for positive and negative images. However, neutral images were considered more pleasant [F(1,143) = 8.4; p = 0.004] and induced a higher level of arousal [F(1,143) = 12.3; p = 0.001] in normothymic bipolar patients than in control subjects. Neutral pictures also triggered a stronger startle reflex in normothymic bipolar patients compared to controls [F(3,123) = 3.1; p = 0.03].
CONCLUSION
Normothymic bipolar patients displayed emotional hyper-reactivity, mostly evidenced in neutral situations. This feature may be linked to emotional dysregulation and is a potential endophenotype and/or a risk factor for bipolar disorders. This trait may be responsible for vulnerability to minor stressful events in everyday life. These findings have potential implications for the daily management of bipolar disorder between crises.
DOI: 10.1111/j.1399-5618.2008.00656.x
PubMed: 19133967
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="M Bailara, Katia" sort="M Bailara, Katia" uniqKey="M Bailara K" first="Katia" last="M'Bailara">Katia M'Bailara</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Psychiatrie Adulte, CHS Charles Perrens, Bordeaux, France.</nlm:affiliation>
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<author><name sortKey="Swendsen, Joel" sort="Swendsen, Joel" uniqKey="Swendsen J" first="Joël" last="Swendsen">Joël Swendsen</name>
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<author><name sortKey="Mathieu, Flavie" sort="Mathieu, Flavie" uniqKey="Mathieu F" first="Flavie" last="Mathieu">Flavie Mathieu</name>
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<series><title level="j">Bipolar disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Affective Symptoms (etiology)</term>
<term>Aged (MeSH)</term>
<term>Arousal (physiology)</term>
<term>Bipolar Disorder (complications)</term>
<term>Bipolar Disorder (psychology)</term>
<term>Blinking (MeSH)</term>
<term>Dysthymic Disorder (MeSH)</term>
<term>Emotions (physiology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Psychiatric Status Rating Scales (MeSH)</term>
<term>Reflex, Startle (physiology)</term>
<term>Young Adult (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Clignement (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Réflexe de sursaut (physiologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Symptômes affectifs (étiologie)</term>
<term>Trouble bipolaire (complications)</term>
<term>Trouble bipolaire (psychologie)</term>
<term>Trouble dysthymique (MeSH)</term>
<term>Échelles d'évaluation en psychiatrie (MeSH)</term>
<term>Émotions (physiologie)</term>
<term>Éveil (physiologie)</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Bipolar Disorder</term>
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<term>Éveil</term>
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<term>Reflex, Startle</term>
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<term>Aged</term>
<term>Blinking</term>
<term>Dysthymic Disorder</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Psychiatric Status Rating Scales</term>
<term>Young Adult</term>
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<term>Adulte d'âge moyen</term>
<term>Clignement</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Normothymic states in bipolar disorders are generally considered to be devoid of severe symptoms. However, bipolar patients present subsyndromal symptoms for half of their lives, and often have comorbid psychiatric disorders. If we go beyond the concept of temperamental features, can we identify certain emotional characteristics distinguishing normothymic bipolar patients from normal controls? We previously showed, using self-completed questionnaires, that normothymic bipolar patients display higher levels of emotional lability and intensity than controls.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>The aim of this study was to assess the emotional reactivity of normothymic bipolar patients, comparing such patients with a normal control group during an experimental mood induction procedure.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHOD</b>
</p>
<p>We evaluated the subjective emotional reactivity of 145 subjects (90 control subjects and 55 normothymic bipolar patients), using an emotional induction method based on the viewing of a set of 18 pictures (6 positive, 6 negative, 6 neutral) extracted from the International Affective Picture System. Subjective valence and arousal were recorded with the Self-Assessment Manikin. We also recorded startle reflexes, triggered by a tone occurring during the viewing of two-thirds of the pictures. We controlled for confounding factors, such as concurrent treatments, in all analyses.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Normothymic bipolar patients and normal controls assessed valence and arousal similarly for positive and negative images. However, neutral images were considered more pleasant [F(1,143) = 8.4; p = 0.004] and induced a higher level of arousal [F(1,143) = 12.3; p = 0.001] in normothymic bipolar patients than in control subjects. Neutral pictures also triggered a stronger startle reflex in normothymic bipolar patients compared to controls [F(3,123) = 3.1; p = 0.03].</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Normothymic bipolar patients displayed emotional hyper-reactivity, mostly evidenced in neutral situations. This feature may be linked to emotional dysregulation and is a potential endophenotype and/or a risk factor for bipolar disorders. This trait may be responsible for vulnerability to minor stressful events in everyday life. These findings have potential implications for the daily management of bipolar disorder between crises.</p>
</div>
</front>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Normothymic states in bipolar disorders are generally considered to be devoid of severe symptoms. However, bipolar patients present subsyndromal symptoms for half of their lives, and often have comorbid psychiatric disorders. If we go beyond the concept of temperamental features, can we identify certain emotional characteristics distinguishing normothymic bipolar patients from normal controls? We previously showed, using self-completed questionnaires, that normothymic bipolar patients display higher levels of emotional lability and intensity than controls.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this study was to assess the emotional reactivity of normothymic bipolar patients, comparing such patients with a normal control group during an experimental mood induction procedure.</AbstractText>
<AbstractText Label="METHOD" NlmCategory="METHODS">We evaluated the subjective emotional reactivity of 145 subjects (90 control subjects and 55 normothymic bipolar patients), using an emotional induction method based on the viewing of a set of 18 pictures (6 positive, 6 negative, 6 neutral) extracted from the International Affective Picture System. Subjective valence and arousal were recorded with the Self-Assessment Manikin. We also recorded startle reflexes, triggered by a tone occurring during the viewing of two-thirds of the pictures. We controlled for confounding factors, such as concurrent treatments, in all analyses.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Normothymic bipolar patients and normal controls assessed valence and arousal similarly for positive and negative images. However, neutral images were considered more pleasant [F(1,143) = 8.4; p = 0.004] and induced a higher level of arousal [F(1,143) = 12.3; p = 0.001] in normothymic bipolar patients than in control subjects. Neutral pictures also triggered a stronger startle reflex in normothymic bipolar patients compared to controls [F(3,123) = 3.1; p = 0.03].</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Normothymic bipolar patients displayed emotional hyper-reactivity, mostly evidenced in neutral situations. This feature may be linked to emotional dysregulation and is a potential endophenotype and/or a risk factor for bipolar disorders. This trait may be responsible for vulnerability to minor stressful events in everyday life. These findings have potential implications for the daily management of bipolar disorder between crises.</AbstractText>
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<tree><noCountry><name sortKey="Demotes Mainard, Jacques" sort="Demotes Mainard, Jacques" uniqKey="Demotes Mainard J" first="Jacques" last="Demotes-Mainard">Jacques Demotes-Mainard</name>
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<name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name>
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<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="M Bailara, Katia" sort="M Bailara, Katia" uniqKey="M Bailara K" first="Katia" last="M'Bailara">Katia M'Bailara</name>
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