Rats orally self-administer corticosterone.
Identifieur interne : 002030 ( Main/Corpus ); précédent : 002029; suivant : 002031Rats orally self-administer corticosterone.
Auteurs : V. Deroche ; P V Piazza ; J M Deminière ; M. Le Moal ; H. SimonSource :
- Brain research [ 0006-8993 ] ; 1993.
English descriptors
- KwdEn :
- Administration, Oral (MeSH), Animals (MeSH), Choice Behavior (drug effects), Conditioning, Classical (drug effects), Corticosterone (administration & dosage), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Reinforcement, Psychology (MeSH), Self Administration (MeSH), Substance-Related Disorders (physiopathology).
- MESH :
- chemical , administration & dosage : Corticosterone.
- drug effects : Choice Behavior, Conditioning, Classical.
- physiopathology : Substance-Related Disorders.
- Administration, Oral, Animals, Rats, Rats, Sprague-Dawley, Reinforcement, Psychology, Self Administration.
Abstract
Corticosterone, the major glucocorticoid in the rat, may modulate the reinforcing properties of addictive drugs as well as act as a positive reinforcer for intravenous self-administration. Since glucocorticoids are generally administered to humans via the oral route, we examined the ability of corticosterone to induce oral self-administration in the rat. In a first experiment, animals with free access to food could choose between a corticosterone solution and water. Three doses (25, 50 and 100 micrograms/ml) were tested. The group receiving the 100 micrograms/ml dose was also submitted to an extinction followed by a reversal test. In a second experiment, we examined whether the reinforcing properties of corticosterone could induce drinking independently of food intake. In the pre-test phase rats had access to food only during a fixed period of the day (11.00 h to 14.00 h). Corticosterone solution (200 micrograms/ml) or tap water were available during this period, with free access to tap water for the rest of the day. During the test period, access to food was shifted forward in time, while the availability of the corticosterone solution remained the same. The first experiment showed that rats preferred a corticosterone solution to tap water, developing self-administration in a dose-dependent manner. This preference could be extinguished, but was regained during the reversal phase. In the second experiment, animals that had access to the corticosterone solution drank more than rats that had access to water in the absence of food. These results indicate that corticosterone has reinforcing properties after oral administration.(ABSTRACT TRUNCATED AT 250 WORDS)
DOI: 10.1016/0006-8993(93)90837-d
PubMed: 8242374
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pubmed:8242374Le document en format XML
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Deroche</name><affiliation><nlm:affiliation>Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259, Université de Bordeaux II, France.</nlm:affiliation></affiliation></author><author><name sortKey="Piazza, P V" sort="Piazza, P V" uniqKey="Piazza P" first="P V" last="Piazza">P V Piazza</name></author><author><name sortKey="Deminiere, J M" sort="Deminiere, J M" uniqKey="Deminiere J" first="J M" last="Deminière">J M Deminière</name></author><author><name sortKey="Le Moal, M" sort="Le Moal, M" uniqKey="Le Moal M" first="M" last="Le Moal">M. Le Moal</name></author><author><name sortKey="Simon, H" sort="Simon, H" uniqKey="Simon H" first="H" last="Simon">H. Simon</name></author></analytic><series><title level="j">Brain research</title><idno type="ISSN">0006-8993</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral (MeSH)</term><term>Animals (MeSH)</term><term>Choice Behavior (drug effects)</term><term>Conditioning, Classical (drug effects)</term><term>Corticosterone (administration & dosage)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Reinforcement, Psychology (MeSH)</term><term>Self Administration (MeSH)</term><term>Substance-Related Disorders (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Corticosterone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Choice Behavior</term><term>Conditioning, Classical</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reinforcement, Psychology</term><term>Self Administration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Corticosterone, the major glucocorticoid in the rat, may modulate the reinforcing properties of addictive drugs as well as act as a positive reinforcer for intravenous self-administration. Since glucocorticoids are generally administered to humans via the oral route, we examined the ability of corticosterone to induce oral self-administration in the rat. In a first experiment, animals with free access to food could choose between a corticosterone solution and water. Three doses (25, 50 and 100 micrograms/ml) were tested. The group receiving the 100 micrograms/ml dose was also submitted to an extinction followed by a reversal test. In a second experiment, we examined whether the reinforcing properties of corticosterone could induce drinking independently of food intake. In the pre-test phase rats had access to food only during a fixed period of the day (11.00 h to 14.00 h). Corticosterone solution (200 micrograms/ml) or tap water were available during this period, with free access to tap water for the rest of the day. During the test period, access to food was shifted forward in time, while the availability of the corticosterone solution remained the same. The first experiment showed that rats preferred a corticosterone solution to tap water, developing self-administration in a dose-dependent manner. This preference could be extinguished, but was regained during the reversal phase. In the second experiment, animals that had access to the corticosterone solution drank more than rats that had access to water in the absence of food. These results indicate that corticosterone has reinforcing properties after oral administration.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8242374</PMID><DateCompleted><Year>1994</Year><Month>01</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-8993</ISSN><JournalIssue CitedMedium="Print"><Volume>622</Volume><Issue>1-2</Issue><PubDate><Year>1993</Year><Month>Sep</Month><Day>17</Day></PubDate></JournalIssue><Title>Brain research</Title><ISOAbbreviation>Brain Res</ISOAbbreviation></Journal><ArticleTitle>Rats orally self-administer corticosterone.</ArticleTitle><Pagination><MedlinePgn>315-20</MedlinePgn></Pagination><Abstract><AbstractText>Corticosterone, the major glucocorticoid in the rat, may modulate the reinforcing properties of addictive drugs as well as act as a positive reinforcer for intravenous self-administration. Since glucocorticoids are generally administered to humans via the oral route, we examined the ability of corticosterone to induce oral self-administration in the rat. In a first experiment, animals with free access to food could choose between a corticosterone solution and water. Three doses (25, 50 and 100 micrograms/ml) were tested. The group receiving the 100 micrograms/ml dose was also submitted to an extinction followed by a reversal test. In a second experiment, we examined whether the reinforcing properties of corticosterone could induce drinking independently of food intake. In the pre-test phase rats had access to food only during a fixed period of the day (11.00 h to 14.00 h). Corticosterone solution (200 micrograms/ml) or tap water were available during this period, with free access to tap water for the rest of the day. During the test period, access to food was shifted forward in time, while the availability of the corticosterone solution remained the same. The first experiment showed that rats preferred a corticosterone solution to tap water, developing self-administration in a dose-dependent manner. This preference could be extinguished, but was regained during the reversal phase. In the second experiment, animals that had access to the corticosterone solution drank more than rats that had access to water in the absence of food. These results indicate that corticosterone has reinforcing properties after oral administration.(ABSTRACT TRUNCATED AT 250 WORDS)</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deroche</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259, Université de Bordeaux II, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piazza</LastName><ForeName>P V</ForeName><Initials>PV</Initials></Author><Author ValidYN="Y"><LastName>Deminière</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Le Moal</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Simon</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Res</MedlineTA><NlmUniqueID>0045503</NlmUniqueID><ISSNLinking>0006-8993</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>W980KJ009P</RegistryNumber><NameOfSubstance UI="D003345">Corticosterone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002755" MajorTopicYN="N">Choice Behavior</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003214" MajorTopicYN="N">Conditioning, Classical</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003345" MajorTopicYN="N">Corticosterone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012054" MajorTopicYN="N">Reinforcement, Psychology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019966" MajorTopicYN="N">Substance-Related Disorders</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>9</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>9</Month><Day>17</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>9</Month><Day>17</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8242374</ArticleId><ArticleId IdType="pii">0006-8993(93)90837-D</ArticleId><ArticleId IdType="doi">10.1016/0006-8993(93)90837-d</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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