Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm.
Identifieur interne : 002029 ( Main/Corpus ); précédent : 002028; suivant : 002030Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm.
Auteurs : Y. Shaham ; L C Klein ; K. Alvares ; N E GrunbergSource :
- Pharmacology, biochemistry, and behavior [ 0091-3057 ] ; 1993.
English descriptors
- KwdEn :
- Animals (MeSH), Body Weight (drug effects), Conditioning, Operant (drug effects), Drinking (drug effects), Electroshock (MeSH), Fentanyl (pharmacology), Male (MeSH), Naloxone (pharmacology), Rats (MeSH), Rats, Wistar (MeSH), Reinforcement Schedule (MeSH), Self Administration (psychology), Stress, Psychological (psychology), Taste (drug effects).
- MESH :
- chemical , pharmacology : Fentanyl, Naloxone.
- drug effects : Body Weight, Conditioning, Operant, Drinking, Taste.
- psychology : Self Administration, Stress, Psychological.
- Animals, Electroshock, Male, Rats, Rats, Wistar, Reinforcement Schedule.
Abstract
The effect of intermittent footshock stress (0.8 mA; 0.2 s on; 40 s off on the average; for 10 min/day) on oral fentanyl (50 or 75 micrograms/ml) self-administration (SA) in operant chambers was examined in male rats. In Experiment 1, after 1 month of initiation of the fentanyl SA by partial water deprivation, animals were tested for lever-pressing for fentanyl (75 micrograms/ml) under fixed-ratio-4 (FR-4) and progressive-ratio (PR) schedules of reinforcement for 30 min/day in operant chambers. Exposure to footshock stress increased fentanyl SA under the FR-4 and PR schedules compared with a nonstress condition. When water was substituted for the drug, the operant behavior persisted before extinction. In Experiment 2, different rats were tested for lever-pressing for fentanyl (50 micrograms/ml) under FR-6 and PR schedules. This experiment further assessed the role of taste in the stress-induced fentanyl SA and examined the effect of increasing the schedule requirements (i.e., FR-3, 6, and 12) on lever-pressing for fentanyl. Exposure to footshock stress increased lever-pressing for oral fentanyl SA under the FR schedules of reinforcement. When a quinine solution (30 micrograms/ml), matched for bitter taste with the fentanyl solution, was substituted for the drug solution, an extinction of the drug-reinforced behavior occurred, indicating that the stress-induced oral fentanyl SA is not related to stress-induced changes in taste sensitivity. In both experiments, no significant stress effects were observed for water consumption in home cage and lever-pressing on the nonoperative lever.
DOI: 10.1016/0091-3057(93)90359-2
PubMed: 8265686
Links to Exploration step
pubmed:8265686Le document en format XML
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Alvares</name></author><author><name sortKey="Grunberg, N E" sort="Grunberg, N E" uniqKey="Grunberg N" first="N E" last="Grunberg">N E Grunberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8265686</idno><idno type="pmid">8265686</idno><idno type="doi">10.1016/0091-3057(93)90359-2</idno><idno type="wicri:Area/Main/Corpus">002029</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002029</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm.</title><author><name sortKey="Shaham, Y" sort="Shaham, Y" uniqKey="Shaham Y" first="Y" last="Shaham">Y. Shaham</name><affiliation><nlm:affiliation>Dept. of Psychology, Concordia University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Klein, L C" sort="Klein, L C" uniqKey="Klein L" first="L C" last="Klein">L C Klein</name></author><author><name sortKey="Alvares, K" sort="Alvares, K" uniqKey="Alvares K" first="K" last="Alvares">K. Alvares</name></author><author><name sortKey="Grunberg, N E" sort="Grunberg, N E" uniqKey="Grunberg N" first="N E" last="Grunberg">N E Grunberg</name></author></analytic><series><title level="j">Pharmacology, biochemistry, and behavior</title><idno type="ISSN">0091-3057</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Body Weight (drug effects)</term><term>Conditioning, Operant (drug effects)</term><term>Drinking (drug effects)</term><term>Electroshock (MeSH)</term><term>Fentanyl (pharmacology)</term><term>Male (MeSH)</term><term>Naloxone (pharmacology)</term><term>Rats (MeSH)</term><term>Rats, Wistar (MeSH)</term><term>Reinforcement Schedule (MeSH)</term><term>Self Administration (psychology)</term><term>Stress, Psychological (psychology)</term><term>Taste (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fentanyl</term><term>Naloxone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Body Weight</term><term>Conditioning, Operant</term><term>Drinking</term><term>Taste</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Self Administration</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electroshock</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term><term>Reinforcement Schedule</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of intermittent footshock stress (0.8 mA; 0.2 s on; 40 s off on the average; for 10 min/day) on oral fentanyl (50 or 75 micrograms/ml) self-administration (SA) in operant chambers was examined in male rats. In Experiment 1, after 1 month of initiation of the fentanyl SA by partial water deprivation, animals were tested for lever-pressing for fentanyl (75 micrograms/ml) under fixed-ratio-4 (FR-4) and progressive-ratio (PR) schedules of reinforcement for 30 min/day in operant chambers. Exposure to footshock stress increased fentanyl SA under the FR-4 and PR schedules compared with a nonstress condition. When water was substituted for the drug, the operant behavior persisted before extinction. In Experiment 2, different rats were tested for lever-pressing for fentanyl (50 micrograms/ml) under FR-6 and PR schedules. This experiment further assessed the role of taste in the stress-induced fentanyl SA and examined the effect of increasing the schedule requirements (i.e., FR-3, 6, and 12) on lever-pressing for fentanyl. Exposure to footshock stress increased lever-pressing for oral fentanyl SA under the FR schedules of reinforcement. When a quinine solution (30 micrograms/ml), matched for bitter taste with the fentanyl solution, was substituted for the drug solution, an extinction of the drug-reinforced behavior occurred, indicating that the stress-induced oral fentanyl SA is not related to stress-induced changes in taste sensitivity. In both experiments, no significant stress effects were observed for water consumption in home cage and lever-pressing on the nonoperative lever.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8265686</PMID><DateCompleted><Year>1994</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0091-3057</ISSN><JournalIssue CitedMedium="Print"><Volume>46</Volume><Issue>2</Issue><PubDate><Year>1993</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Pharmacology, biochemistry, and behavior</Title><ISOAbbreviation>Pharmacol Biochem Behav</ISOAbbreviation></Journal><ArticleTitle>Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm.</ArticleTitle><Pagination><MedlinePgn>315-22</MedlinePgn></Pagination><Abstract><AbstractText>The effect of intermittent footshock stress (0.8 mA; 0.2 s on; 40 s off on the average; for 10 min/day) on oral fentanyl (50 or 75 micrograms/ml) self-administration (SA) in operant chambers was examined in male rats. In Experiment 1, after 1 month of initiation of the fentanyl SA by partial water deprivation, animals were tested for lever-pressing for fentanyl (75 micrograms/ml) under fixed-ratio-4 (FR-4) and progressive-ratio (PR) schedules of reinforcement for 30 min/day in operant chambers. Exposure to footshock stress increased fentanyl SA under the FR-4 and PR schedules compared with a nonstress condition. When water was substituted for the drug, the operant behavior persisted before extinction. In Experiment 2, different rats were tested for lever-pressing for fentanyl (50 micrograms/ml) under FR-6 and PR schedules. This experiment further assessed the role of taste in the stress-induced fentanyl SA and examined the effect of increasing the schedule requirements (i.e., FR-3, 6, and 12) on lever-pressing for fentanyl. Exposure to footshock stress increased lever-pressing for oral fentanyl SA under the FR schedules of reinforcement. When a quinine solution (30 micrograms/ml), matched for bitter taste with the fentanyl solution, was substituted for the drug solution, an extinction of the drug-reinforced behavior occurred, indicating that the stress-induced oral fentanyl SA is not related to stress-induced changes in taste sensitivity. In both experiments, no significant stress effects were observed for water consumption in home cage and lever-pressing on the nonoperative lever.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shaham</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Dept. of Psychology, Concordia University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>L C</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Alvares</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Grunberg</LastName><ForeName>N E</ForeName><Initials>NE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pharmacol Biochem Behav</MedlineTA><NlmUniqueID>0367050</NlmUniqueID><ISSNLinking>0091-3057</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>36B82AMQ7N</RegistryNumber><NameOfSubstance UI="D009270">Naloxone</NameOfSubstance></Chemical><Chemical><RegistryNumber>UF599785JZ</RegistryNumber><NameOfSubstance UI="D005283">Fentanyl</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003216" MajorTopicYN="N">Conditioning, Operant</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004326" MajorTopicYN="N">Drinking</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004597" MajorTopicYN="N">Electroshock</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005283" MajorTopicYN="N">Fentanyl</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009270" MajorTopicYN="N">Naloxone</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012055" MajorTopicYN="N">Reinforcement Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013649" MajorTopicYN="N">Taste</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8265686</ArticleId><ArticleId IdType="pii">0091-3057(93)90359-2</ArticleId><ArticleId IdType="doi">10.1016/0091-3057(93)90359-2</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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