Tissue culture and toxicology
Identifieur interne : 000E24 ( Main/Exploration ); précédent : 000E23; suivant : 000E25Tissue culture and toxicology
Auteurs : P. C. Rofe [Royaume-Uni]Source :
- Food and Cosmetics Toxicology [ 0015-6264 ] ; 1971.
English descriptors
- Teeft :
- Adult tissue, Agar, Animal tissues, Archs envir, Automatic perfusion system, Average period, Basal cells, Biol, Bourel, Calf serum, Cancer inst, Cell biol, Cell cultures, Cell growth, Cell populations, Cell types, Cell viability, Certain modifications, Chick embryo, Chromatographic separation, Cigarette smoke, Colourless zone, Connective tissue, Culture fluid, Culture medium, Culturing cells, Cytotoxic effect, Different approach, Electron microscopy, Embryo, Embryonic tissues, Expl, Expl cell, Fibroblast, Fluid medium, Foie humain adulte, Foreign compounds, Foreign substances, Frog heart, Good agreement, Guilly, Hanks wallace, High oxygen demand, Histological examination, Human cells, Human endometrium, Human liver, Human tissues, Individual cells, Inhibitory effect, Kruse, Kruse miedema, Laboratory animals, Large numbers, Liver cells, Long periods, Mammalian cell cultures, Mammalian cells, Metabolism, Metal grid, Mitotic activity, Monocellular layer, Monolayer tissue cultures, Monolayers, Morphological change, Mouse embryos, Mouse fibroblasts, Organ culture, Other hand, Other tissues, Perforated cellophane, Perfusion, Perfusion system, Pergamon press, Permanent cell strains, Permanent strain, Permanent strains, Plating efficiency, Primary culture, Primary cultures, Proc, Quantitative histochemistry, Rabbit skin, Relative toxicities, Respiration, Rofe, Same conditions, Several months, Several pieces, Small quantities, Test compound, Test substance, Tissue culture, Tissue cultures, Toxic, Toxicity, Toxicological, Toxicological studies, Toxicology, Tracheal rings, Triethyl citrate, Trowell, Vivo, Wide range.
Abstract
Abstract: Current methods of tissue culture are described, including techniques for the measurement of cell viability and growth. Literature on the utilization of tissue culture to measure the toxicity of a wide range of substances is reviewed. Of a variety of techniques used, most depend on reduction of viability or growth rates, but inhibition of cell respiration, morphological change and several other parameters have also been observed. However, there appears to have been no systematic comparison of the reaction of normal adult human tissues and animal tissues in toxicological studies. This paper offers proposals for research in which a selection of animal tissues would be compared with human tissue in their response to substances for which substantial data from in vivo toxicology already exist. The results of such work should permit a relatively simple predictive test procedure to be selected.
Url:
DOI: 10.1016/0015-6264(71)90159-3
Affiliations:
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Le document en format XML
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Rofe</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Huntingdon Research Centre, Huntingdon, PE18 6ES</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Food and Cosmetics Toxicology</title><title level="j" type="abbrev">FCTOX</title><idno type="ISSN">0015-6264</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1971">1971</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="683">683</biblScope><biblScope unit="page" to="696">696</biblScope></imprint><idno type="ISSN">0015-6264</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0015-6264</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adult tissue</term><term>Agar</term><term>Animal tissues</term><term>Archs envir</term><term>Automatic perfusion system</term><term>Average period</term><term>Basal cells</term><term>Biol</term><term>Bourel</term><term>Calf serum</term><term>Cancer inst</term><term>Cell biol</term><term>Cell cultures</term><term>Cell growth</term><term>Cell populations</term><term>Cell types</term><term>Cell viability</term><term>Certain modifications</term><term>Chick embryo</term><term>Chromatographic separation</term><term>Cigarette smoke</term><term>Colourless zone</term><term>Connective tissue</term><term>Culture fluid</term><term>Culture medium</term><term>Culturing cells</term><term>Cytotoxic effect</term><term>Different approach</term><term>Electron microscopy</term><term>Embryo</term><term>Embryonic tissues</term><term>Expl</term><term>Expl cell</term><term>Fibroblast</term><term>Fluid medium</term><term>Foie humain adulte</term><term>Foreign compounds</term><term>Foreign substances</term><term>Frog heart</term><term>Good agreement</term><term>Guilly</term><term>Hanks wallace</term><term>High oxygen demand</term><term>Histological examination</term><term>Human cells</term><term>Human endometrium</term><term>Human liver</term><term>Human tissues</term><term>Individual cells</term><term>Inhibitory effect</term><term>Kruse</term><term>Kruse miedema</term><term>Laboratory animals</term><term>Large numbers</term><term>Liver cells</term><term>Long periods</term><term>Mammalian cell cultures</term><term>Mammalian cells</term><term>Metabolism</term><term>Metal grid</term><term>Mitotic activity</term><term>Monocellular layer</term><term>Monolayer tissue cultures</term><term>Monolayers</term><term>Morphological change</term><term>Mouse embryos</term><term>Mouse fibroblasts</term><term>Organ culture</term><term>Other hand</term><term>Other tissues</term><term>Perforated cellophane</term><term>Perfusion</term><term>Perfusion system</term><term>Pergamon press</term><term>Permanent cell strains</term><term>Permanent strain</term><term>Permanent strains</term><term>Plating efficiency</term><term>Primary culture</term><term>Primary cultures</term><term>Proc</term><term>Quantitative histochemistry</term><term>Rabbit skin</term><term>Relative toxicities</term><term>Respiration</term><term>Rofe</term><term>Same conditions</term><term>Several months</term><term>Several pieces</term><term>Small quantities</term><term>Test compound</term><term>Test substance</term><term>Tissue culture</term><term>Tissue cultures</term><term>Toxic</term><term>Toxicity</term><term>Toxicological</term><term>Toxicological studies</term><term>Toxicology</term><term>Tracheal rings</term><term>Triethyl citrate</term><term>Trowell</term><term>Vivo</term><term>Wide range</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Current methods of tissue culture are described, including techniques for the measurement of cell viability and growth. Literature on the utilization of tissue culture to measure the toxicity of a wide range of substances is reviewed. Of a variety of techniques used, most depend on reduction of viability or growth rates, but inhibition of cell respiration, morphological change and several other parameters have also been observed. However, there appears to have been no systematic comparison of the reaction of normal adult human tissues and animal tissues in toxicological studies. This paper offers proposals for research in which a selection of animal tissues would be compared with human tissue in their response to substances for which substantial data from in vivo toxicology already exist. The results of such work should permit a relatively simple predictive test procedure to be selected.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rofe, P C" sort="Rofe, P C" uniqKey="Rofe P" first="P. C." last="Rofe">P. C. Rofe</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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