Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings
Identifieur interne : 000D54 ( Main/Exploration ); précédent : 000D53; suivant : 000D55Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings
Auteurs : Liselotte Moser [Allemagne] ; K. J. Hüther [France] ; J. Koch-Weser [France] ; P. V. Lundt [Allemagne]Source :
- European Journal of Clinical Pharmacology [ 0031-6970 ] ; 1978-11-01.
English descriptors
- KwdEn :
- Teeft :
- Antihistamine, Ball cylinder test, Choice reaction time, Clin, Color signals, Critical flicker frequency, Diazepam, Diphenhydramine, Drug administration, Many antihistamines, Moser, Other antihistamines, Pharmacol, Placebo, Post drug post drug, Present study, Psychomotor, Psychomotor performance, Psychomotor skills, Reaction time, Significant change, Significant differences, Significant impairment, Single reaction time, Subjective feeling, Subjective feelings, System side effects, Terfenadine, Vienna reaction apparatus, Vienna reaction apparatus test.
Abstract
Summary: The effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were evaluated in a double-blind, crossover study in 20 normal male volunteers. Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings, whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.
Url:
DOI: 10.1007/BF00716383
Affiliations:
- Allemagne, France
- Alsace (région administrative), District de Cologne, Grand Est, Rhénanie-du-Nord-Westphalie
- Cologne, Strasbourg
Links toward previous steps (curation, corpus...)
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- to stream Main, to step Curation: 000D54
Le document en format XML
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Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings, whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>Alsace (région administrative)</li><li>District de Cologne</li><li>Grand Est</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Cologne</li><li>Strasbourg</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Moser, Liselotte" sort="Moser, Liselotte" uniqKey="Moser L" first="Liselotte" last="Moser">Liselotte Moser</name></region><name sortKey="Lundt, P V" sort="Lundt, P V" uniqKey="Lundt P" first="P. V." last="Lundt">P. V. Lundt</name></country><country name="France"><region name="Grand Est"><name sortKey="Huther, K J" sort="Huther, K J" uniqKey="Huther K" first="K. J." last="Hüther">K. J. Hüther</name></region><name sortKey="Koch Weser, J" sort="Koch Weser, J" uniqKey="Koch Weser J" first="J." last="Koch-Weser">J. Koch-Weser</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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