Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings
Identifieur interne : 000D68 ( Main/Merge ); précédent : 000D67; suivant : 000D69Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings
Auteurs : Liselotte Moser [Allemagne] ; K. J. Hüther [France] ; J. Koch-Weser [France] ; P. V. Lundt [Allemagne]Source :
- European Journal of Clinical Pharmacology [ 0031-6970 ] ; 1978-11-01.
English descriptors
- KwdEn :
- Teeft :
- Antihistamine, Ball cylinder test, Choice reaction time, Clin, Color signals, Critical flicker frequency, Diazepam, Diphenhydramine, Drug administration, Many antihistamines, Moser, Other antihistamines, Pharmacol, Placebo, Post drug post drug, Present study, Psychomotor, Psychomotor performance, Psychomotor skills, Reaction time, Significant change, Significant differences, Significant impairment, Single reaction time, Subjective feeling, Subjective feelings, System side effects, Terfenadine, Vienna reaction apparatus, Vienna reaction apparatus test.
Abstract
Summary: The effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were evaluated in a double-blind, crossover study in 20 normal male volunteers. Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings, whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.
Url:
DOI: 10.1007/BF00716383
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ISTEX:A464DD4BA2505D5F34884DC0AA33B16E720AAD12Le document en format XML
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<author><name sortKey="Koch Weser, J" sort="Koch Weser, J" uniqKey="Koch Weser J" first="J." last="Koch-Weser">J. Koch-Weser</name>
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<series><title level="j">European Journal of Clinical Pharmacology</title>
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<term>effects on psychomotor performance and subjective feelings</term>
<term>terfenadine</term>
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<term>Present study</term>
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<term>Psychomotor performance</term>
<term>Psychomotor skills</term>
<term>Reaction time</term>
<term>Significant change</term>
<term>Significant differences</term>
<term>Significant impairment</term>
<term>Single reaction time</term>
<term>Subjective feeling</term>
<term>Subjective feelings</term>
<term>System side effects</term>
<term>Terfenadine</term>
<term>Vienna reaction apparatus</term>
<term>Vienna reaction apparatus test</term>
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<front><div type="abstract" xml:lang="en">Summary: The effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were evaluated in a double-blind, crossover study in 20 normal male volunteers. Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings, whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.</div>
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