The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Identifieur interne : 000A62 ( Main/Exploration ); précédent : 000A61; suivant : 000A63The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Auteurs : Q. Chen ; J T Cheng ; L H Tasi ; N. Schneider ; G. Buchanan ; A. Carroll ; W. Crist ; B. Ozanne ; M J Siciliano ; R. BaerSource :
- The EMBO Journal [ 0261-4189 ] ; 1990.
Abstract
We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.
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PubMed: 2303035
PubMed Central: 551682
Affiliations:
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Carroll</name></author><author><name sortKey="Crist, W" sort="Crist, W" uniqKey="Crist W" first="W" last="Crist">W. Crist</name></author><author><name sortKey="Ozanne, B" sort="Ozanne, B" uniqKey="Ozanne B" first="B" last="Ozanne">B. Ozanne</name></author><author><name sortKey="Siciliano, M J" sort="Siciliano, M J" uniqKey="Siciliano M" first="M J" last="Siciliano">M J Siciliano</name></author><author><name sortKey="Baer, R" sort="Baer, R" uniqKey="Baer R" first="R" last="Baer">R. 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Chen</name></author><author><name sortKey="Cheng, J T" sort="Cheng, J T" uniqKey="Cheng J" first="J T" last="Cheng">J T Cheng</name></author><author><name sortKey="Tasi, L H" sort="Tasi, L H" uniqKey="Tasi L" first="L H" last="Tasi">L H Tasi</name></author><author><name sortKey="Schneider, N" sort="Schneider, N" uniqKey="Schneider N" first="N" last="Schneider">N. Schneider</name></author><author><name sortKey="Buchanan, G" sort="Buchanan, G" uniqKey="Buchanan G" first="G" last="Buchanan">G. Buchanan</name></author><author><name sortKey="Carroll, A" sort="Carroll, A" uniqKey="Carroll A" first="A" last="Carroll">A. Carroll</name></author><author><name sortKey="Crist, W" sort="Crist, W" uniqKey="Crist W" first="W" last="Crist">W. Crist</name></author><author><name sortKey="Ozanne, B" sort="Ozanne, B" uniqKey="Ozanne B" first="B" last="Ozanne">B. Ozanne</name></author><author><name sortKey="Siciliano, M J" sort="Siciliano, M J" uniqKey="Siciliano M" first="M J" last="Siciliano">M J Siciliano</name></author><author><name sortKey="Baer, R" sort="Baer, R" uniqKey="Baer R" first="R" last="Baer">R. Baer</name></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="1990">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 1.</label><graphic xlink:href="emboj00229-0108-a" xlink:role="415"></graphic></fig><fig id="F2"><label>Fig. 3.</label><graphic xlink:href="emboj00229-0110-a" xlink:role="417"></graphic></fig><fig id="F3"><label>Fig. 6.</label><graphic xlink:href="emboj00229-0111-a" xlink:role="418"></graphic></fig></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baer, R" sort="Baer, R" uniqKey="Baer R" first="R" last="Baer">R. Baer</name><name sortKey="Buchanan, G" sort="Buchanan, G" uniqKey="Buchanan G" first="G" last="Buchanan">G. Buchanan</name><name sortKey="Carroll, A" sort="Carroll, A" uniqKey="Carroll A" first="A" last="Carroll">A. Carroll</name><name sortKey="Chen, Q" sort="Chen, Q" uniqKey="Chen Q" first="Q" last="Chen">Q. Chen</name><name sortKey="Cheng, J T" sort="Cheng, J T" uniqKey="Cheng J" first="J T" last="Cheng">J T Cheng</name><name sortKey="Crist, W" sort="Crist, W" uniqKey="Crist W" first="W" last="Crist">W. Crist</name><name sortKey="Ozanne, B" sort="Ozanne, B" uniqKey="Ozanne B" first="B" last="Ozanne">B. Ozanne</name><name sortKey="Schneider, N" sort="Schneider, N" uniqKey="Schneider N" first="N" last="Schneider">N. Schneider</name><name sortKey="Siciliano, M J" sort="Siciliano, M J" uniqKey="Siciliano M" first="M J" last="Siciliano">M J Siciliano</name><name sortKey="Tasi, L H" sort="Tasi, L H" uniqKey="Tasi L" first="L H" last="Tasi">L H Tasi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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