The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Identifieur interne : 000138 ( Pmc/Curation ); précédent : 000137; suivant : 000139The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Auteurs : Q. Chen ; J T Cheng ; L H Tasi ; N. Schneider ; G. Buchanan ; A. Carroll ; W. Crist ; B. Ozanne ; M J Siciliano ; R. BaerSource :
- The EMBO Journal [ 0261-4189 ] ; 1990.
Abstract
We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.
Url:
PubMed: 2303035
PubMed Central: 551682
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000138
Links to Exploration step
PMC:551682Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.</title>
<author><name sortKey="Chen, Q" sort="Chen, Q" uniqKey="Chen Q" first="Q" last="Chen">Q. Chen</name>
</author>
<author><name sortKey="Cheng, J T" sort="Cheng, J T" uniqKey="Cheng J" first="J T" last="Cheng">J T Cheng</name>
</author>
<author><name sortKey="Tasi, L H" sort="Tasi, L H" uniqKey="Tasi L" first="L H" last="Tasi">L H Tasi</name>
</author>
<author><name sortKey="Schneider, N" sort="Schneider, N" uniqKey="Schneider N" first="N" last="Schneider">N. Schneider</name>
</author>
<author><name sortKey="Buchanan, G" sort="Buchanan, G" uniqKey="Buchanan G" first="G" last="Buchanan">G. Buchanan</name>
</author>
<author><name sortKey="Carroll, A" sort="Carroll, A" uniqKey="Carroll A" first="A" last="Carroll">A. Carroll</name>
</author>
<author><name sortKey="Crist, W" sort="Crist, W" uniqKey="Crist W" first="W" last="Crist">W. Crist</name>
</author>
<author><name sortKey="Ozanne, B" sort="Ozanne, B" uniqKey="Ozanne B" first="B" last="Ozanne">B. Ozanne</name>
</author>
<author><name sortKey="Siciliano, M J" sort="Siciliano, M J" uniqKey="Siciliano M" first="M J" last="Siciliano">M J Siciliano</name>
</author>
<author><name sortKey="Baer, R" sort="Baer, R" uniqKey="Baer R" first="R" last="Baer">R. Baer</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">2303035</idno>
<idno type="pmc">551682</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551682</idno>
<idno type="RBID">PMC:551682</idno>
<date when="1990">1990</date>
<idno type="wicri:Area/Pmc/Corpus">000138</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000138</idno>
<idno type="wicri:Area/Pmc/Curation">000138</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000138</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.</title>
<author><name sortKey="Chen, Q" sort="Chen, Q" uniqKey="Chen Q" first="Q" last="Chen">Q. Chen</name>
</author>
<author><name sortKey="Cheng, J T" sort="Cheng, J T" uniqKey="Cheng J" first="J T" last="Cheng">J T Cheng</name>
</author>
<author><name sortKey="Tasi, L H" sort="Tasi, L H" uniqKey="Tasi L" first="L H" last="Tasi">L H Tasi</name>
</author>
<author><name sortKey="Schneider, N" sort="Schneider, N" uniqKey="Schneider N" first="N" last="Schneider">N. Schneider</name>
</author>
<author><name sortKey="Buchanan, G" sort="Buchanan, G" uniqKey="Buchanan G" first="G" last="Buchanan">G. Buchanan</name>
</author>
<author><name sortKey="Carroll, A" sort="Carroll, A" uniqKey="Carroll A" first="A" last="Carroll">A. Carroll</name>
</author>
<author><name sortKey="Crist, W" sort="Crist, W" uniqKey="Crist W" first="W" last="Crist">W. Crist</name>
</author>
<author><name sortKey="Ozanne, B" sort="Ozanne, B" uniqKey="Ozanne B" first="B" last="Ozanne">B. Ozanne</name>
</author>
<author><name sortKey="Siciliano, M J" sort="Siciliano, M J" uniqKey="Siciliano M" first="M J" last="Siciliano">M J Siciliano</name>
</author>
<author><name sortKey="Baer, R" sort="Baer, R" uniqKey="Baer R" first="R" last="Baer">R. Baer</name>
</author>
</analytic>
<series><title level="j">The EMBO Journal</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><date when="1990">1990</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.</p>
<sec sec-type="scanned-figures"><title>Images</title>
<fig id="F1"><label>Fig. 1.</label>
<graphic xlink:href="emboj00229-0108-a" xlink:role="415"></graphic>
</fig>
<fig id="F2"><label>Fig. 3.</label>
<graphic xlink:href="emboj00229-0110-a" xlink:role="417"></graphic>
</fig>
<fig id="F3"><label>Fig. 6.</label>
<graphic xlink:href="emboj00229-0111-a" xlink:role="418"></graphic>
</fig>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id>
<journal-title>The EMBO Journal</journal-title>
<issn pub-type="ppub">0261-4189</issn>
<issn pub-type="epub">1460-2075</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">2303035</article-id>
<article-id pub-id-type="pmc">551682</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Q</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>J T</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tasi</surname>
<given-names>L H</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Schneider</surname>
<given-names>N</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Buchanan</surname>
<given-names>G</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Carroll</surname>
<given-names>A</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Crist</surname>
<given-names>W</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ozanne</surname>
<given-names>B</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Siciliano</surname>
<given-names>M J</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Baer</surname>
<given-names>R</given-names>
</name>
</contrib>
</contrib-group>
<aff>Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.</aff>
<pub-date pub-type="ppub"><month>2</month>
<year>1990</year>
</pub-date>
<volume>9</volume>
<issue>2</issue>
<fpage>415</fpage>
<lpage>424</lpage>
<abstract><p>We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.</p>
<sec sec-type="scanned-figures"><title>Images</title>
<fig id="F1"><label>Fig. 1.</label>
<graphic xlink:href="emboj00229-0108-a" xlink:role="415"></graphic>
</fig>
<fig id="F2"><label>Fig. 3.</label>
<graphic xlink:href="emboj00229-0110-a" xlink:role="417"></graphic>
</fig>
<fig id="F3"><label>Fig. 6.</label>
<graphic xlink:href="emboj00229-0111-a" xlink:role="418"></graphic>
</fig>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000138 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000138 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Psychologie |area= BernheimV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:551682 |texte= The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:2303035" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a BernheimV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |