Mosaicism in the C-banded region of chromosome 1 in cancer families
Identifieur interne : 000741 ( Istex/Corpus ); précédent : 000740; suivant : 000742Mosaicism in the C-banded region of chromosome 1 in cancer families
Auteurs : Luisa Doneda ; Annamaria Fuhrman Conti ; Valter Gualandri ; Lidia LarizzaSource :
- Cancer Genetics and Cytogenetics [ 0165-4608 ] ; 1987.
English descriptors
- Teeft :
- Adenocarcinoma, Cancer families, Cancer family members, Cancer genet cytogenet, Cancer predisposition, Cancer proneness, Carcinoma, Cell population, Chromosome, Chromosome analysis, Colonic adenocarcinoma, Cytogenet, Different pattern, Family tree, Gastric cancer, Genet, Genetic instability, Healthy subject, Heterochromatic, Heterochromatin, High incidence, Human chromosomes, Lidia larizza, Malignant melanoma, Mosaicism, Possible relationship, Telecobalt therapy, Testicular cancer, Tumor patients, Unequal mitotic, Unstable genotype, Variant.
Abstract
Abstract: Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.
Url:
DOI: 10.1016/0165-4608(87)90008-2
Links to Exploration step
ISTEX:119A79B6411C0526FA15AAA5C5F0175AC1EBED96Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Mosaicism in the C-banded region of chromosome 1 in cancer families</title><author><name sortKey="Doneda, Luisa" sort="Doneda, Luisa" uniqKey="Doneda L" first="Luisa" last="Doneda">Luisa Doneda</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Conti, Annamaria Fuhrman" sort="Conti, Annamaria Fuhrman" uniqKey="Conti A" first="Annamaria Fuhrman" last="Conti">Annamaria Fuhrman Conti</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Gualandri, Valter" sort="Gualandri, Valter" uniqKey="Gualandri V" first="Valter" last="Gualandri">Valter Gualandri</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Larizza, Lidia" sort="Larizza, Lidia" uniqKey="Larizza L" first="Lidia" last="Larizza">Lidia Larizza</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:119A79B6411C0526FA15AAA5C5F0175AC1EBED96</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1016/0165-4608(87)90008-2</idno><idno type="url">https://api.istex.fr/document/119A79B6411C0526FA15AAA5C5F0175AC1EBED96/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000741</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000741</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Mosaicism in the C-banded region of chromosome 1 in cancer families</title><author><name sortKey="Doneda, Luisa" sort="Doneda, Luisa" uniqKey="Doneda L" first="Luisa" last="Doneda">Luisa Doneda</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Conti, Annamaria Fuhrman" sort="Conti, Annamaria Fuhrman" uniqKey="Conti A" first="Annamaria Fuhrman" last="Conti">Annamaria Fuhrman Conti</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Gualandri, Valter" sort="Gualandri, Valter" uniqKey="Gualandri V" first="Valter" last="Gualandri">Valter Gualandri</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Larizza, Lidia" sort="Larizza, Lidia" uniqKey="Larizza L" first="Lidia" last="Larizza">Lidia Larizza</name><affiliation><mods:affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cancer Genetics and Cytogenetics</title><title level="j" type="abbrev">CGC</title><idno type="ISSN">0165-4608</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="261">261</biblScope><biblScope unit="page" to="268">268</biblScope></imprint><idno type="ISSN">0165-4608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-4608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenocarcinoma</term><term>Cancer families</term><term>Cancer family members</term><term>Cancer genet cytogenet</term><term>Cancer predisposition</term><term>Cancer proneness</term><term>Carcinoma</term><term>Cell population</term><term>Chromosome</term><term>Chromosome analysis</term><term>Colonic adenocarcinoma</term><term>Cytogenet</term><term>Different pattern</term><term>Family tree</term><term>Gastric cancer</term><term>Genet</term><term>Genetic instability</term><term>Healthy subject</term><term>Heterochromatic</term><term>Heterochromatin</term><term>High incidence</term><term>Human chromosomes</term><term>Lidia larizza</term><term>Malignant melanoma</term><term>Mosaicism</term><term>Possible relationship</term><term>Telecobalt therapy</term><term>Testicular cancer</term><term>Tumor patients</term><term>Unequal mitotic</term><term>Unstable genotype</term><term>Variant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>chromosome</json:string><json:string>heterochromatin</json:string><json:string>genet</json:string><json:string>mosaicism</json:string><json:string>heterochromatic</json:string><json:string>adenocarcinoma</json:string><json:string>cytogenet</json:string><json:string>cancer families</json:string><json:string>cancer genet cytogenet</json:string><json:string>tumor patients</json:string><json:string>carcinoma</json:string><json:string>human chromosomes</json:string><json:string>chromosome analysis</json:string><json:string>variant</json:string><json:string>unequal mitotic</json:string><json:string>family tree</json:string><json:string>possible relationship</json:string><json:string>gastric cancer</json:string><json:string>cancer family members</json:string><json:string>testicular cancer</json:string><json:string>malignant melanoma</json:string><json:string>genetic instability</json:string><json:string>telecobalt therapy</json:string><json:string>colonic adenocarcinoma</json:string><json:string>different pattern</json:string><json:string>cell population</json:string><json:string>healthy subject</json:string><json:string>unstable genotype</json:string><json:string>cancer proneness</json:string><json:string>cancer predisposition</json:string><json:string>lidia larizza</json:string><json:string>high incidence</json:string></teeft></keywords><author><json:item><name>Luisa Doneda</name><affiliations><json:string>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</json:string></affiliations></json:item><json:item><name>Annamaria Fuhrman Conti</name><affiliations><json:string>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</json:string></affiliations></json:item><json:item><name>Valter Gualandri</name><affiliations><json:string>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</json:string></affiliations></json:item><json:item><name>Lidia Larizza</name><affiliations><json:string>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-SKW7R860-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.</abstract><qualityIndicators><score>6.812</score><pdfWordCount>3204</pdfWordCount><pdfCharCount>15192</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>468 x 742 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>134</abstractWordCount><abstractCharCount>916</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Mosaicism in the C-banded region of chromosome 1 in cancer families</title><pmid><json:string>3594415</json:string></pmid><pii><json:string>0165-4608(87)90008-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Cancer Genetics and Cytogenetics</title><language><json:string>unknown</json:string></language><publicationDate>1987</publicationDate><issn><json:string>0165-4608</json:string></issn><pii><json:string>S0165-4608(00)X0173-2</json:string></pii><volume>27</volume><issue>2</issue><pages><first>261</first><last>268</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1987</json:string></date><geogName><json:string>Ill</json:string></geogName><orgName><json:string>Science Publishing Co.</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Valter Gualandri</json:string><json:string>The</json:string><json:string>Annamaria Fuhrman</json:string><json:string>Lidia Larizza</json:string><json:string>Via Viatti</json:string></persName><placeName><json:string>NY</json:string><json:string>York</json:string><json:string>Italy</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[4]</json:string><json:string>[18]</json:string><json:string>L. Doneda et al.</json:string><json:string>[11]</json:string><json:string>[8]</json:string><json:string>[19, 20]</json:string><json:string>[21]</json:string><json:string>[1-4]</json:string><json:string>Craig-Holmes et al. [7]</json:string><json:string>[7, 8]</json:string><json:string>[15]</json:string><json:string>[14]</json:string><json:string>[9]</json:string><json:string>Cohen et al. [12]</json:string><json:string>[16, 17]</json:string><json:string>[4-6]</json:string><json:string>[2]</json:string><json:string>[13]</json:string><json:string>Shabtai et al. [4]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-SKW7R860-9</json:string></ark><categories><wos></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - oncology & carcinogenesis</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Cancer Research</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Genetics</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Molecular Biology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1987</publicationDate><copyrightDate>1987</copyrightDate><doi><json:string>10.1016/0165-4608(87)90008-2</json:string></doi><id>119A79B6411C0526FA15AAA5C5F0175AC1EBED96</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/119A79B6411C0526FA15AAA5C5F0175AC1EBED96/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/119A79B6411C0526FA15AAA5C5F0175AC1EBED96/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/119A79B6411C0526FA15AAA5C5F0175AC1EBED96/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Mosaicism in the C-banded region of chromosome 1 in cancer families</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1987</date></publicationStmt><notesStmt><note type="content">Section title: Original article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Mosaicism in the C-banded region of chromosome 1 in cancer families</title><author xml:id="author-0000"><persName><forename type="first">Luisa</forename><surname>Doneda</surname></persName><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Annamaria Fuhrman</forename><surname>Conti</surname></persName><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Valter</forename><surname>Gualandri</surname></persName><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Lidia</forename><surname>Larizza</surname></persName><note type="biography">Address requests for reprints to Dr. Lidia Larizza, Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Via Viotti 5, 20133-Milan, Italy.</note><note type="biography">Supported by C. N. R. P. F. “Oncologia,” Grant No. 85. 02213.</note><affiliation>Address requests for reprints to Dr. Lidia Larizza, Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Via Viotti 5, 20133-Milan, Italy.</affiliation><affiliation>Supported by C. N. R. P. F. “Oncologia,” Grant No. 85. 02213.</affiliation><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation></author><idno type="istex">119A79B6411C0526FA15AAA5C5F0175AC1EBED96</idno><idno type="DOI">10.1016/0165-4608(87)90008-2</idno><idno type="PII">0165-4608(87)90008-2</idno></analytic><monogr><title level="j">Cancer Genetics and Cytogenetics</title><title level="j" type="abbrev">CGC</title><idno type="pISSN">0165-4608</idno><idno type="PII">S0165-4608(00)X0173-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987"></date><biblScope unit="volume">27</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="261">261</biblScope><biblScope unit="page" to="268">268</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1987</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.</p></abstract></profileDesc><revisionDesc><change when="1987">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/119A79B6411C0526FA15AAA5C5F0175AC1EBED96/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>CGC</jid><aid>87900082</aid><ce:pii>0165-4608(87)90008-2</ce:pii><ce:doi>10.1016/0165-4608(87)90008-2</ce:doi><ce:copyright type="unknown" year="1987"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Original article</ce:textfn></ce:dochead><ce:title>Mosaicism in the C-banded region of chromosome 1 in cancer families</ce:title><ce:author-group><ce:author><ce:given-name>Luisa</ce:given-name><ce:surname>Doneda</ce:surname></ce:author><ce:author><ce:given-name>Annamaria Fuhrman</ce:given-name><ce:surname>Conti</ce:surname></ce:author><ce:author><ce:given-name>Valter</ce:given-name><ce:surname>Gualandri</ce:surname></ce:author><ce:author><ce:given-name>Lidia</ce:given-name><ce:surname>Larizza</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address requests for reprints to Dr. Lidia Larizza, Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Via Viotti 5, 20133-Milan, Italy.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Supported by C. N. R. P. F. “Oncologia,” Grant No. 85. 02213.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="25" month="7" year="1986"></ce:date-received><ce:date-accepted day="6" month="11" year="1986"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Mosaicism in the C-banded region of chromosome 1 in cancer families</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Mosaicism in the C-banded region of chromosome 1 in cancer families</title></titleInfo><name type="personal"><namePart type="given">Luisa</namePart><namePart type="family">Doneda</namePart><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annamaria Fuhrman</namePart><namePart type="family">Conti</namePart><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valter</namePart><namePart type="family">Gualandri</namePart><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lidia</namePart><namePart type="family">Larizza</namePart><affiliation>Department of Biology and Genetics, Medical Faculty, University of Milan, Italy.</affiliation><description>Address requests for reprints to Dr. Lidia Larizza, Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Via Viotti 5, 20133-Milan, Italy.</description><description>Supported by C. N. R. P. F. “Oncologia,” Grant No. 85. 02213.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1987</dateIssued><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.</abstract><note type="content">Section title: Original article</note><relatedItem type="host"><titleInfo><title>Cancer Genetics and Cytogenetics</title></titleInfo><titleInfo type="abbreviated"><title>CGC</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">198708</dateIssued></originInfo><identifier type="ISSN">0165-4608</identifier><identifier type="PII">S0165-4608(00)X0173-2</identifier><part><date>198708</date><detail type="volume"><number>27</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>191</start><end>377</end></extent><extent unit="pages"><start>261</start><end>268</end></extent></part></relatedItem><identifier type="istex">119A79B6411C0526FA15AAA5C5F0175AC1EBED96</identifier><identifier type="ark">ark:/67375/6H6-SKW7R860-9</identifier><identifier type="DOI">10.1016/0165-4608(87)90008-2</identifier><identifier type="PII">0165-4608(87)90008-2</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/119A79B6411C0526FA15AAA5C5F0175AC1EBED96/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000741 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000741 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= BernheimV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:119A79B6411C0526FA15AAA5C5F0175AC1EBED96
|texte= Mosaicism in the C-banded region of chromosome 1 in cancer families
}}
| This area was generated with Dilib version V0.6.33. |  |