Eosinophils in innate immunity: an evolving story
Identifieur interne : 000728 ( Istex/Curation ); précédent : 000727; suivant : 000729Eosinophils in innate immunity: an evolving story
Auteurs : Revital Shamri [États-Unis] ; Jason J. Xenakis [États-Unis] ; Lisa A. Spencer [États-Unis]Source :
- Cell and Tissue Research [ 0302-766X ] ; 2011-01-01.
English descriptors
Abstract
Abstract: Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.
Url:
DOI: 10.1007/s00441-010-1049-6
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<front><div type="abstract" xml:lang="en">Abstract: Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.</div>
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