Eosinophils in innate immunity: an evolving story
Identifieur interne : 000728 ( Istex/Corpus ); précédent : 000727; suivant : 000729Eosinophils in innate immunity: an evolving story
Auteurs : Revital Shamri ; Jason J. Xenakis ; Lisa A. SpencerSource :
- Cell and Tissue Research [ 0302-766X ] ; 2011-01-01.
English descriptors
Abstract
Abstract: Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.
Url:
DOI: 10.1007/s00441-010-1049-6
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ISTEX:435BF3FD41F0093BFBBBB505627EF7013B8917C3Le document en format XML
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Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Revital Shamri</name><affiliations><json:string>Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02215, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Jason J. Xenakis</name><affiliations><json:string>Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02215, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Lisa A. 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ID="Aff1"><OrgDivision>Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center</OrgDivision><OrgName>Harvard Medical School</OrgName><OrgAddress><City>Boston</City><State>MA</State><Postcode>02215</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgAddress><Street>330 Brookline Avenue, E/CLS Rm 935</Street><City>Boston</City><State>MA</State><Postcode>02215</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Eosinophil</Keyword><Keyword>Innate immunity</Keyword><Keyword>Immunomodulation</Keyword><Keyword>Tissue remodeling</Keyword><Keyword>Piecemeal secretion</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>This work was supported by NIH grant HL095699 and an AHA Grant-in-Aid to L.A.S.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Eosinophils in innate immunity: an evolving story</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Eosinophils in innate immunity: an evolving story</title></titleInfo><name type="personal"><namePart type="given">Revital</namePart><namePart type="family">Shamri</namePart><affiliation>Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02215, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jason</namePart><namePart type="given">J.</namePart><namePart type="family">Xenakis</namePart><affiliation>Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02215, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Lisa</namePart><namePart type="given">A.</namePart><namePart type="family">Spencer</namePart><affiliation>Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02215, Boston, MA, USA</affiliation><affiliation>330 Brookline Avenue, E/CLS Rm 935, 02215, Boston, MA, USA</affiliation><affiliation>E-mail: lspencer@bidmc.harvard.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2010-08-17</dateCreated><dateIssued encoding="w3cdtf">2011-01-01</dateIssued><dateIssued encoding="w3cdtf">2010</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. 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