Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients
Identifieur interne : 000A13 ( Main/Exploration ); précédent : 000A12; suivant : 000A14Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients
Auteurs : T. Bosch ; T. Wendler ; B. R. Jaeger ; W. SamtlebenSource :
- Therapeutic Apheresis [ 1091-6660 ] ; 2001-10.
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Abstract
Abstract: Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.
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DOI: 10.1046/j.1526-0968.2001.00368.x
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Samtleben</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8B81EBD46A69C072AB4C0986BAE2EDA566C99D3E</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1046/j.1526-0968.2001.00368.x</idno><idno type="url">https://api.istex.fr/document/8B81EBD46A69C072AB4C0986BAE2EDA566C99D3E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D93</idno><idno type="wicri:Area/Main/Curation">000D71</idno><idno type="wicri:Area/Main/Exploration">000A13</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000A13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients</title><author><name sortKey="Bosch, T" sort="Bosch, T" uniqKey="Bosch T" first="T." last="Bosch">T. Bosch</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Wendler, T" sort="Wendler, T" uniqKey="Wendler T" first="T." last="Wendler">T. Wendler</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Jaeger, B R" sort="Jaeger, B R" uniqKey="Jaeger B" first="B. R." last="Jaeger">B. R. Jaeger</name><affiliation><wicri:noCountry code="subField"> Germany</wicri:noCountry></affiliation></author><author><name sortKey="Samtleben, W" sort="Samtleben, W" uniqKey="Samtleben W" first="W." last="Samtleben">W. Samtleben</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Therapeutic Apheresis</title><title level="j" type="abbrev">Therapeutic Apheresis</title><idno type="ISSN">1091-6660</idno><idno type="eISSN">1526-0968</idno><imprint><publisher>Blackwell Science Inc</publisher><pubPlace>Boston, MA, USA</pubPlace><date type="published" when="2001-10">2001-10</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="372">372</biblScope><biblScope unit="page" to="376">376</biblScope></imprint><idno type="ISSN">1091-6660</idno></series><idno type="istex">8B81EBD46A69C072AB4C0986BAE2EDA566C99D3E</idno><idno type="DOI">10.1046/j.1526-0968.2001.00368.x</idno><idno type="ArticleID">TAP368</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1091-6660</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Direct adsorption of lipoproteins</term><term>Erythrocyte aggregability</term><term>Hemorheology</term><term>Low‐density lipoprotein apheresis</term><term>Plasma viscosity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bosch, T" sort="Bosch, T" uniqKey="Bosch T" first="T." last="Bosch">T. Bosch</name><name sortKey="Jaeger, B R" sort="Jaeger, B R" uniqKey="Jaeger B" first="B. R." last="Jaeger">B. R. Jaeger</name><name sortKey="Samtleben, W" sort="Samtleben, W" uniqKey="Samtleben W" first="W." last="Samtleben">W. Samtleben</name><name sortKey="Wendler, T" sort="Wendler, T" uniqKey="Wendler T" first="T." last="Wendler">T. Wendler</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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