Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients
Identifieur interne : 000D93 ( Main/Corpus ); précédent : 000D92; suivant : 000D94Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients
Auteurs : T. Bosch ; T. Wendler ; B. R. Jaeger ; W. SamtlebenSource :
- Therapeutic Apheresis [ 1091-6660 ] ; 2001-10.
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Abstract
Abstract: Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.
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DOI: 10.1046/j.1526-0968.2001.00368.x
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Bosch</name><affiliation><mods:affiliation>Nephrology Division, Department I of Internal Medicine and</mods:affiliation></affiliation></author><author><name sortKey="Wendler, T" sort="Wendler, T" uniqKey="Wendler T" first="T." last="Wendler">T. Wendler</name><affiliation><mods:affiliation>Nephrology Division, Department I of Internal Medicine and</mods:affiliation></affiliation></author><author><name sortKey="Jaeger, B R" sort="Jaeger, B R" uniqKey="Jaeger B" first="B. R." last="Jaeger">B. R. Jaeger</name><affiliation><mods:affiliation>Institute of Clinical Chemistry, Klinikum Grosshadern, Munich University Hospital, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Samtleben, W" sort="Samtleben, W" uniqKey="Samtleben W" first="W." last="Samtleben">W. Samtleben</name><affiliation><mods:affiliation>Nephrology Division, Department I of Internal Medicine and</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Therapeutic Apheresis</title><title level="j" type="abbrev">Therapeutic Apheresis</title><idno type="ISSN">1091-6660</idno><idno type="eISSN">1526-0968</idno><imprint><publisher>Blackwell Science Inc</publisher><pubPlace>Boston, MA, USA</pubPlace><date type="published" when="2001-10">2001-10</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="372">372</biblScope><biblScope unit="page" to="376">376</biblScope></imprint><idno type="ISSN">1091-6660</idno></series><idno type="istex">8B81EBD46A69C072AB4C0986BAE2EDA566C99D3E</idno><idno type="DOI">10.1046/j.1526-0968.2001.00368.x</idno><idno type="ArticleID">TAP368</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1091-6660</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Direct adsorption of lipoproteins</term><term>Erythrocyte aggregability</term><term>Hemorheology</term><term>Low‐density lipoprotein apheresis</term><term>Plasma viscosity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>T. Bosch</name><affiliations><json:string>Nephrology Division, Department I of Internal Medicine and</json:string></affiliations></json:item><json:item><name>T. Wendler</name><affiliations><json:string>Nephrology Division, Department I of Internal Medicine and</json:string></affiliations></json:item><json:item><name>B.R. Jaeger</name><affiliations><json:string>Institute of Clinical Chemistry, Klinikum Grosshadern, Munich University Hospital, Munich, Germany</json:string></affiliations></json:item><json:item><name>W. Samtleben</name><affiliations><json:string>Nephrology Division, Department I of Internal Medicine and</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Direct adsorption of lipoproteins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Erythrocyte aggregability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hemorheology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Low‐density lipoprotein apheresis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Plasma viscosity</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Abstract: Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. 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Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Direct adsorption of lipoproteins</term></item><item><term>Erythrocyte aggregability</term></item><item><term>Hemorheology</term></item><item><term>Low‐density lipoprotein apheresis</term></item><item><term>Plasma viscosity</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8B81EBD46A69C072AB4C0986BAE2EDA566C99D3E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Inc</publisherName><publisherLoc>Boston, MA, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1526-0968</doi><issn type="print">1091-6660</issn><issn type="electronic">1526-0968</issn><idGroup><id type="product" value="TAP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="THERAPEUTIC APHERESIS">Therapeutic Apheresis</title><title type="short">Therapeutic Apheresis</title></titleGroup></publicationMeta><publicationMeta level="part" position="10005"><doi origin="wiley">10.1111/tap.2001.5.issue-5</doi><numberingGroup><numbering type="journalVolume" number="5">5</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2001-10">October 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0037200" status="forIssue"><doi origin="wiley">10.1046/j.1526-0968.2001.00368.x</doi><idGroup><id type="unit" value="TAP368"></id><id type="supplier" value="t5"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2001-12-29"></event><event type="publishedOnlineFinalForm" date="2001-12-29"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="372">372</numbering><numbering type="pageLast" number="376">376</numbering></numberingGroup><correspondenceTo>Address correspondence and reprint requests to Dr. Thomas Bosch, Nephrology Division, Department I of Internal Medicine, Klinikum Grosshadern, Munich University Hospital, D‐81366 Munich, Germany. E‐mail: <email normalForm="bosch@med1.med.uni-muenchen.de">bosch@med1.med.uni‐muenchen.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TAP.TAP368.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received May 2001.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="1"></count><count type="referenceTotal" number="21"></count><count type="wordTotal" number="5193"></count><count type="linksPubMed" number="16"></count><count type="linksCrossRef" number="1"></count></countGroup><titleGroup><title type="main">Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>T.</givenNames><familyName>Bosch</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>T.</givenNames><familyName>Wendler</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>B.R.</givenNames><familyName>Jaeger</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>W.</givenNames><familyName>Samtleben</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Nephrology Division, Department I of Internal Medicine and</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Institute of Clinical Chemistry, Klinikum Grosshadern, Munich University Hospital, Munich, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Direct adsorption of lipoproteins</keyword><keyword xml:id="k2">Erythrocyte aggregability</keyword><keyword xml:id="k3">Hemorheology</keyword><keyword xml:id="k4">Low‐density lipoprotein apheresis</keyword><keyword xml:id="k5">Plasma viscosity</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract:</b> Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Improvement of Hemorheology by DALI Apheresis: Acute Effects on Plasma Viscosity and Erythrocyte Aggregation in Hypercholesterolemic Patients</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Bosch</namePart><affiliation>Nephrology Division, Department I of Internal Medicine and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Wendler</namePart><affiliation>Nephrology Division, Department I of Internal Medicine and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.R.</namePart><namePart type="family">Jaeger</namePart><affiliation>Institute of Clinical Chemistry, Klinikum Grosshadern, Munich University Hospital, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Samtleben</namePart><affiliation>Nephrology Division, Department I of Internal Medicine and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science Inc</publisher><place><placeTerm type="text">Boston, MA, USA</placeTerm></place><dateIssued encoding="w3cdtf">2001-10</dateIssued><edition>Received May 2001.</edition><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="formulas">1</extent><extent unit="references">21</extent><extent unit="words">5193</extent></physicalDescription><abstract lang="en">Abstract: Plasma viscosity (PV) and erythrocyte aggregation (EA) are determinants of microcirculation, especially under the compromised hemodynamic conditions resulting from atherosclerosis. Direct adsorption of lipoproteins (DALI) apheresis is the first method for direct adsorption of lipoproteins; it drastically reduces low‐density lipoprotein (LDL)‐cholesterol and lipoprotein (a) (Lp[a]), and may therefore improve PV and EA. The current study was performed to test the effect of DALI on hemorheology. Six hypercholesterolemic patients who had been on regular LDL apheresis for at least several months were treated on a weekly or biweekly basis, on average 5 times each by DALI. Before and after each session, PV was measured by a capillary tube plasma viscosimeter and EA by rotational aggregometry. Single DALI sessions (n = 31) acutely decreased PV from 1.18 ± 0.04 to 1.06 ± 0.3 mPa (−10%) while EA improved from 22.8 ± 4.4 to 13.3 ± 4.5 (arbitrary units) (−42%). LDL‐cholesterol, Lp(a), and very‐low‐density lipoprotein (VLDL)‐cholesterol were effectively reduced while the decrease of triglycerides and fibrinogen was only moderate. DALI apheresis exerted an acute positive effect on blood hemorheology which may have beneficial effects on microcirculation. This hypothesis is in accordance with the clinical observation that in some patients, improvement of angina and/or exercise tolerance can be observed after only a few DALI sessions where changes of coronary stenoses cannot be expected yet.</abstract><subject lang="en"><genre>Keywords</genre><topic>Direct adsorption of lipoproteins</topic><topic>Erythrocyte aggregability</topic><topic>Hemorheology</topic><topic>Low‐density lipoprotein apheresis</topic><topic>Plasma viscosity</topic></subject><relatedItem type="host"><titleInfo><title>Therapeutic Apheresis</title></titleInfo><titleInfo type="abbreviated"><title>Therapeutic Apheresis</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1091-6660</identifier><identifier type="eISSN">1526-0968</identifier><identifier type="DOI">10.1111/(ISSN)1526-0968</identifier><identifier type="PublisherID">TAP</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>372</start><end>376</end><total>5</total></extent></part></relatedItem><identifier type="istex">8B81EBD46A69C072AB4C0986BAE2EDA566C99D3E</identifier><identifier type="DOI">10.1046/j.1526-0968.2001.00368.x</identifier><identifier type="ArticleID">TAP368</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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