Comparative systems biology: from bacteria to man
Identifieur interne : 001070 ( Main/Curation ); précédent : 001069; suivant : 001071Comparative systems biology: from bacteria to man
Auteurs : Bas Teusink [Pays-Bas] ; Hans V. Westerhoff [Pays-Bas, Royaume-Uni] ; Frank J. Bruggeman [Pays-Bas]Source :
- Wiley Interdisciplinary Reviews: Systems Biology and Medicine [ 1939-5094 ] ; 2010-09.
Abstract
Comparative analyses, as carried out by comparative genomics and bioinformatics, have proven extremely powerful to obtain insight into the identity of specific genes that underlie differences and similarities across species. The central concept developed in this chapter is that important aspects of the functional differences between organisms derive not only from the differences in genetic components (which underlies comparative genomics) but also from dynamic, molecular (physical) interactions. Approaches that aim at identifying such network‐based rather than component‐based homologies between species we shall call Comparative Systems Biology. It will be illustrated by a number of examples from metabolic networks from prokaryotes, via yeast, to man. The potential for species comparisons, at the genome‐scale using classical approaches and at the more detailed level of dynamic molecular networks will be illustrated. In our opinion, comparative systems biology, as a marriage between bioinformatics and systems biology, will offer new insights into the nature of organisms for the benefit of medicine, biotechnology, and drug design. As dynamic modeling is becoming more mainstream in cell biology, the potential of comparative systems biology will become more evident. Copyright © 2010 John Wiley & Sons, Inc. For further resources related to this article, please visit the WIREs website.
Url:
DOI: 10.1002/wsbm.74
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001115
Links to Exploration step
ISTEX:D4D22179DCBD8D7B42D198508870857ED5C1AE2ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative systems biology: from bacteria to man</title>
<author><name sortKey="Teusink, Bas" sort="Teusink, Bas" uniqKey="Teusink B" first="Bas" last="Teusink">Bas Teusink</name>
<affiliation wicri:level="1"><mods:affiliation>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Netherlands Institute Systems Biology (NISB), The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Institute Systems Biology (NISB)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Kluyver Center for Genomics of Industrial Fermentation, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Kluyver Center for Genomics of Industrial Fermentation</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Westerhoff, Hans V" sort="Westerhoff, Hans V" uniqKey="Westerhoff H" first="Hans V." last="Westerhoff">Hans V. Westerhoff</name>
<affiliation wicri:level="1"><mods:affiliation>Netherlands Institute Systems Biology (NISB), The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Institute Systems Biology (NISB)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Molecular Cell Physiology, VU University Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Molecular Cell Physiology, VU University Amsterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Manchester Centre for Integrative Systems Biology, University of Manchester, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Manchester Centre for Integrative Systems Biology, University of Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruggeman, Frank J" sort="Bruggeman, Frank J" uniqKey="Bruggeman F" first="Frank J." last="Bruggeman">Frank J. Bruggeman</name>
<affiliation wicri:level="1"><mods:affiliation>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Regulatory Networks Group, NISB, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Regulatory Networks Group, NISB</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Life Sciences, Centre for Mathematics and Computer Science (CWI) Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Life Sciences, Centre for Mathematics and Computer Science (CWI) Amsterdam</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D4D22179DCBD8D7B42D198508870857ED5C1AE2A</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/wsbm.74</idno>
<idno type="url">https://api.istex.fr/document/D4D22179DCBD8D7B42D198508870857ED5C1AE2A/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001115</idno>
<idno type="wicri:Area/Main/Curation">001070</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparative systems biology: from bacteria to man</title>
<author><name sortKey="Teusink, Bas" sort="Teusink, Bas" uniqKey="Teusink B" first="Bas" last="Teusink">Bas Teusink</name>
<affiliation wicri:level="1"><mods:affiliation>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Netherlands Institute Systems Biology (NISB), The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Institute Systems Biology (NISB)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Kluyver Center for Genomics of Industrial Fermentation, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Kluyver Center for Genomics of Industrial Fermentation</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Westerhoff, Hans V" sort="Westerhoff, Hans V" uniqKey="Westerhoff H" first="Hans V." last="Westerhoff">Hans V. Westerhoff</name>
<affiliation wicri:level="1"><mods:affiliation>Netherlands Institute Systems Biology (NISB), The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Institute Systems Biology (NISB)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Molecular Cell Physiology, VU University Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Molecular Cell Physiology, VU University Amsterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Manchester Centre for Integrative Systems Biology, University of Manchester, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Manchester Centre for Integrative Systems Biology, University of Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruggeman, Frank J" sort="Bruggeman, Frank J" uniqKey="Bruggeman F" first="Frank J." last="Bruggeman">Frank J. Bruggeman</name>
<affiliation wicri:level="1"><mods:affiliation>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Systems BioInformatics, Center for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Regulatory Networks Group, NISB, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Regulatory Networks Group, NISB</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Life Sciences, Centre for Mathematics and Computer Science (CWI) Amsterdam, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Life Sciences, Centre for Mathematics and Computer Science (CWI) Amsterdam</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Wiley Interdisciplinary Reviews: Systems Biology and Medicine</title>
<title level="j" type="abbrev">WIREs Syst Biol Med</title>
<idno type="ISSN">1939-5094</idno>
<idno type="eISSN">1939-005X</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>Hoboken, USA</pubPlace>
<date type="published" when="2010-09">2010-09</date>
<biblScope unit="volume">2</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="518">518</biblScope>
<biblScope unit="page" to="532">532</biblScope>
</imprint>
<idno type="ISSN">1939-5094</idno>
</series>
<idno type="istex">D4D22179DCBD8D7B42D198508870857ED5C1AE2A</idno>
<idno type="DOI">10.1002/wsbm.74</idno>
<idno type="ArticleID">WSBM74</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1939-5094</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Comparative analyses, as carried out by comparative genomics and bioinformatics, have proven extremely powerful to obtain insight into the identity of specific genes that underlie differences and similarities across species. The central concept developed in this chapter is that important aspects of the functional differences between organisms derive not only from the differences in genetic components (which underlies comparative genomics) but also from dynamic, molecular (physical) interactions. Approaches that aim at identifying such network‐based rather than component‐based homologies between species we shall call Comparative Systems Biology. It will be illustrated by a number of examples from metabolic networks from prokaryotes, via yeast, to man. The potential for species comparisons, at the genome‐scale using classical approaches and at the more detailed level of dynamic molecular networks will be illustrated. In our opinion, comparative systems biology, as a marriage between bioinformatics and systems biology, will offer new insights into the nature of organisms for the benefit of medicine, biotechnology, and drug design. As dynamic modeling is becoming more mainstream in cell biology, the potential of comparative systems biology will become more evident. Copyright © 2010 John Wiley & Sons, Inc. For further resources related to this article, please visit the WIREs website.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/SchutzV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001070 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001070 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Musique |area= SchutzV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:D4D22179DCBD8D7B42D198508870857ED5C1AE2A |texte= Comparative systems biology: from bacteria to man }}
This area was generated with Dilib version V0.6.38. |