ApoE phenotype is associated with inflammatory markers in middle-aged subjects.
Identifieur interne : 000411 ( PubMed/Curation ); précédent : 000410; suivant : 000412ApoE phenotype is associated with inflammatory markers in middle-aged subjects.
Auteurs : O. Ukkola [Finlande] ; A. Kunnari ; M. Jokela ; M. P Iv Nsalo ; Y A Kes NiemiSource :
- Inflammation research : official journal of the European Histamine Research Society ... [et al.] ; 2009.
English descriptors
- KwdEn :
- Adult, Apolipoproteins E (metabolism), Atherosclerosis (metabolism), Atherosclerosis (pathology), Biomarkers (blood), C-Reactive Protein (metabolism), Female, Humans, Male, Middle Aged, Phenotype, Resistin (blood), Tunica Intima (anatomy & histology), Tunica Intima (ultrasonography), Tunica Media (anatomy & histology), Tunica Media (ultrasonography).
- MESH :
- chemical , blood : Biomarkers, Resistin.
- chemical , metabolism : Apolipoproteins E, C-Reactive Protein.
- anatomy & histology : Tunica Intima, Tunica Media.
- metabolism : Atherosclerosis.
- pathology : Atherosclerosis.
- ultrasonography : Tunica Intima, Tunica Media.
- Adult, Female, Humans, Male, Middle Aged, Phenotype.
Abstract
Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.
DOI: 10.1007/s00011-008-8215-2
PubMed: 19115037
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pubmed:19115037Le document en format XML
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<author><name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O" last="Ukkola">O. Ukkola</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Biocenter Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Internal Medicine, Biocenter Oulu, Oulu</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kunnari, A" sort="Kunnari, A" uniqKey="Kunnari A" first="A" last="Kunnari">A. Kunnari</name>
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<author><name sortKey="Jokela, M" sort="Jokela, M" uniqKey="Jokela M" first="M" last="Jokela">M. Jokela</name>
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<author><name sortKey="P Iv Nsalo, M" sort="P Iv Nsalo, M" uniqKey="P Iv Nsalo M" first="M" last="P Iv Nsalo">M. P Iv Nsalo</name>
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<author><name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y A" last="Kes Niemi">Y A Kes Niemi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">ApoE phenotype is associated with inflammatory markers in middle-aged subjects.</title>
<author><name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O" last="Ukkola">O. Ukkola</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Biocenter Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Internal Medicine, Biocenter Oulu, Oulu</wicri:regionArea>
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<author><name sortKey="Kunnari, A" sort="Kunnari, A" uniqKey="Kunnari A" first="A" last="Kunnari">A. Kunnari</name>
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<author><name sortKey="Jokela, M" sort="Jokela, M" uniqKey="Jokela M" first="M" last="Jokela">M. Jokela</name>
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<author><name sortKey="P Iv Nsalo, M" sort="P Iv Nsalo, M" uniqKey="P Iv Nsalo M" first="M" last="P Iv Nsalo">M. P Iv Nsalo</name>
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<author><name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y A" last="Kes Niemi">Y A Kes Niemi</name>
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<series><title level="j">Inflammation research : official journal of the European Histamine Research Society ... [et al.]</title>
<idno type="e-ISSN">1420-908X</idno>
<imprint><date when="2009" type="published">2009</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Apolipoproteins E (metabolism)</term>
<term>Atherosclerosis (metabolism)</term>
<term>Atherosclerosis (pathology)</term>
<term>Biomarkers (blood)</term>
<term>C-Reactive Protein (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Phenotype</term>
<term>Resistin (blood)</term>
<term>Tunica Intima (anatomy & histology)</term>
<term>Tunica Intima (ultrasonography)</term>
<term>Tunica Media (anatomy & histology)</term>
<term>Tunica Media (ultrasonography)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Resistin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apolipoproteins E</term>
<term>C-Reactive Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Tunica Intima</term>
<term>Tunica Media</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Tunica Intima</term>
<term>Tunica Media</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Phenotype</term>
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<front><div type="abstract" xml:lang="en">Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19115037</PMID>
<DateCreated><Year>2009</Year>
<Month>01</Month>
<Day>20</Day>
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<DateCompleted><Year>2009</Year>
<Month>04</Month>
<Day>14</Day>
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<Month>11</Month>
<Day>19</Day>
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<Issue>1</Issue>
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<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Inflammation research : official journal of the European Histamine Research Society ... [et al.]</Title>
<ISOAbbreviation>Inflamm. Res.</ISOAbbreviation>
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<ArticleTitle>ApoE phenotype is associated with inflammatory markers in middle-aged subjects.</ArticleTitle>
<Pagination><MedlinePgn>54-9</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00011-008-8215-2</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Middle-aged subjects of the population- based cohort (n = 526) of the OPERA- study were studied. Intima-media thickness (IMT) was measured with carotid ultrasound. The results suggest that, apoE phenotype was a significant independent predictive factor for resistin (p < 0.01) and hsCRP (p < 0.01) levels. The association of ApoE phenotype with hsCRP was seen among the subjects with the normal renal function (p = 0.005). ApoE4 was associated (p < 0.01) with the lowest hsCRP in the lowest IMT quartile while it's relation with the highest resistin levels was evident in the highest IMT quartile.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">ApoE phenotype is an independent determinant of plasma resistin and hsCRP levels. The extent of atherosclerosis and renal function seem to modify the effects of apoE phenotype on inflammatory parameters.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ukkola</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Biocenter Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</Affiliation>
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<Author ValidYN="Y"><LastName>Kunnari</LastName>
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<Author ValidYN="Y"><LastName>Jokela</LastName>
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<Author ValidYN="Y"><LastName>Päivänsalo</LastName>
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<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Inflamm Res</MedlineTA>
<NlmUniqueID>9508160</NlmUniqueID>
<ISSNLinking>1023-3830</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001057">Apolipoproteins E</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D052243">Resistin</NameOfSubstance>
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<Chemical><RegistryNumber>9007-41-4</RegistryNumber>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D050197">Atherosclerosis</DescriptorName>
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<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010641">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D052243">Resistin</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017539">Tunica Intima</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000033">anatomy & histology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017540">Tunica Media</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000033">anatomy & histology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName>
</MeshHeading>
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</MedlineCitation>
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