ApoE phenotype is associated with inflammatory markers in middle-aged subjects.
Identifieur interne : 000411 ( PubMed/Corpus ); précédent : 000410; suivant : 000412ApoE phenotype is associated with inflammatory markers in middle-aged subjects.
Auteurs : O. Ukkola ; A. Kunnari ; M. Jokela ; M. P Iv Nsalo ; Y A Kes NiemiSource :
- Inflammation research : official journal of the European Histamine Research Society ... [et al.] ; 2009.
English descriptors
- KwdEn :
- Adult, Apolipoproteins E (metabolism), Atherosclerosis (metabolism), Atherosclerosis (pathology), Biomarkers (blood), C-Reactive Protein (metabolism), Female, Humans, Male, Middle Aged, Phenotype, Resistin (blood), Tunica Intima (anatomy & histology), Tunica Intima (ultrasonography), Tunica Media (anatomy & histology), Tunica Media (ultrasonography).
- MESH :
- chemical , blood : Biomarkers, Resistin.
- chemical , metabolism : Apolipoproteins E, C-Reactive Protein.
- anatomy & histology : Tunica Intima, Tunica Media.
- metabolism : Atherosclerosis.
- pathology : Atherosclerosis.
- ultrasonography : Tunica Intima, Tunica Media.
- Adult, Female, Humans, Male, Middle Aged, Phenotype.
Abstract
Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.
DOI: 10.1007/s00011-008-8215-2
PubMed: 19115037
Links to Exploration step
pubmed:19115037Le document en format XML
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P Iv Nsalo</name></author><author><name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y A" last="Kes Niemi">Y A Kes Niemi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1007/s00011-008-8215-2</idno><idno type="RBID">pubmed:19115037</idno><idno type="pmid">19115037</idno><idno type="wicri:Area/PubMed/Corpus">000411</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ApoE phenotype is associated with inflammatory markers in middle-aged subjects.</title><author><name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O" last="Ukkola">O. Ukkola</name><affiliation><nlm:affiliation>Department of Internal Medicine, Biocenter Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</nlm:affiliation></affiliation></author><author><name sortKey="Kunnari, A" sort="Kunnari, A" uniqKey="Kunnari A" first="A" last="Kunnari">A. Kunnari</name></author><author><name sortKey="Jokela, M" sort="Jokela, M" uniqKey="Jokela M" first="M" last="Jokela">M. Jokela</name></author><author><name sortKey="P Iv Nsalo, M" sort="P Iv Nsalo, M" uniqKey="P Iv Nsalo M" first="M" last="P Iv Nsalo">M. P Iv Nsalo</name></author><author><name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y A" last="Kes Niemi">Y A Kes Niemi</name></author></analytic><series><title level="j">Inflammation research : official journal of the European Histamine Research Society ... [et al.]</title><idno type="e-ISSN">1420-908X</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Apolipoproteins E (metabolism)</term><term>Atherosclerosis (metabolism)</term><term>Atherosclerosis (pathology)</term><term>Biomarkers (blood)</term><term>C-Reactive Protein (metabolism)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Resistin (blood)</term><term>Tunica Intima (anatomy & histology)</term><term>Tunica Intima (ultrasonography)</term><term>Tunica Media (anatomy & histology)</term><term>Tunica Media (ultrasonography)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Resistin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apolipoproteins E</term><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Tunica Intima</term><term>Tunica Media</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Tunica Intima</term><term>Tunica Media</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19115037</PMID><DateCreated><Year>2009</Year><Month>01</Month><Day>20</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1420-908X</ISSN><JournalIssue CitedMedium="Internet"><Volume>58</Volume><Issue>1</Issue><PubDate><Year>2009</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Inflammation research : official journal of the European Histamine Research Society ... [et al.]</Title><ISOAbbreviation>Inflamm. Res.</ISOAbbreviation></Journal><ArticleTitle>ApoE phenotype is associated with inflammatory markers in middle-aged subjects.</ArticleTitle><Pagination><MedlinePgn>54-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00011-008-8215-2</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Middle-aged subjects of the population- based cohort (n = 526) of the OPERA- study were studied. Intima-media thickness (IMT) was measured with carotid ultrasound. The results suggest that, apoE phenotype was a significant independent predictive factor for resistin (p < 0.01) and hsCRP (p < 0.01) levels. The association of ApoE phenotype with hsCRP was seen among the subjects with the normal renal function (p = 0.005). ApoE4 was associated (p < 0.01) with the lowest hsCRP in the lowest IMT quartile while it's relation with the highest resistin levels was evident in the highest IMT quartile.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">ApoE phenotype is an independent determinant of plasma resistin and hsCRP levels. The extent of atherosclerosis and renal function seem to modify the effects of apoE phenotype on inflammatory parameters.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ukkola</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Biocenter Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kunnari</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Jokela</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Päivänsalo</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kesäniemi</LastName><ForeName>Y A</ForeName><Initials>YA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Inflamm Res</MedlineTA><NlmUniqueID>9508160</NlmUniqueID><ISSNLinking>1023-3830</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001057">Apolipoproteins E</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052243">Resistin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001057">Apolipoproteins E</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050197">Atherosclerosis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biomarkers</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002097">C-Reactive Protein</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010641">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D052243">Resistin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017539">Tunica Intima</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017540">Tunica Media</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>12</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>12</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s00011-008-8215-2</ArticleId><ArticleId IdType="pubmed">19115037</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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