Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes.
Identifieur interne : 000577 ( PubMed/Corpus ); précédent : 000576; suivant : 000578Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes.
Auteurs : Seppo M. Pöykkö ; Eija Kellokoski ; Sohvi Hörkkö ; Heikki Kauma ; Y Antero Kes Niemi ; Olavi UkkolaSource :
- Diabetes [ 0012-1797 ] ; 2003.
English descriptors
- KwdEn :
- Adult, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2 (blood), Diabetes Mellitus, Type 2 (epidemiology), Female, Finland (epidemiology), Ghrelin, Humans, Hypertension (blood), Hypertension (genetics), Insulin Resistance (physiology), Male, Middle Aged, Mutation, Osmolar Concentration, Peptide Hormones (blood), Peptide Hormones (genetics), Prevalence, Risk Factors.
- MESH :
- chemical , blood : Peptide Hormones.
- chemical , genetics : Peptide Hormones.
- chemical : Ghrelin.
- geographic , epidemiology : Finland.
- blood : Diabetes Mellitus, Type 2, Hypertension.
- epidemiology : Diabetes Mellitus, Type 2.
- genetics : Hypertension.
- physiology : Insulin Resistance.
- Adult, Case-Control Studies, Cohort Studies, Female, Humans, Male, Middle Aged, Mutation, Osmolar Concentration, Prevalence, Risk Factors.
Abstract
Experimental studies have suggested that ghrelin plays a role in glucose homeostasis and in the regulation of blood pressure (BP). We therefore assessed the hypothesis that a low ghrelin concentration may be a risk factor for type 2 diabetes and hypertension. We also characterized the effect of the ghrelin Arg51Gln and Leu72Met mutations on ghrelin concentrations in the population-based hypertensive (n = 519) and control (n = 526) cohorts of our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study. The fasting plasma ghrelin concentrations of 1,040 subjects were analyzed using the radioimmunoassay method. Insulin sensitivity was assessed using the quantitative insulin sensitivity check index (QUICKI). Ghrelin concentrations were negatively associated with fasting insulin (P < 0.001), systolic (P = 0.026) and diastolic BP (P = 0.018), and the prevalence of type 2 diabetes (P = 0.015) and insulin resistance (P < 0.001) in the multivariate models. In the control cohort, low ghrelin was associated with hypertension (BP >140/90 mmHg) (P = 0.031). The subjects with the ghrelin 51Gln allele had lower ghrelin concentrations than the Arg51Arg homozygotes (P = 0.001). We conclude that low ghrelin is independently associated with type 2 diabetes, insulin concentration, insulin resistance, and elevated BP. Therefore, it might have some role in the etiology of type 2 diabetes and the regulation of BP. The ghrelin Arg51Gln mutation is associated with low plasma ghrelin concentrations.
PubMed: 14514639
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pubmed:14514639Le document en format XML
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Pöykkö</name><affiliation><nlm:affiliation>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. seppo.poykko@ppshp.fi</nlm:affiliation></affiliation></author><author><name sortKey="Kellokoski, Eija" sort="Kellokoski, Eija" uniqKey="Kellokoski E" first="Eija" last="Kellokoski">Eija Kellokoski</name></author><author><name sortKey="Horkko, Sohvi" sort="Horkko, Sohvi" uniqKey="Horkko S" first="Sohvi" last="Hörkkö">Sohvi Hörkkö</name></author><author><name sortKey="Kauma, Heikki" sort="Kauma, Heikki" uniqKey="Kauma H" first="Heikki" last="Kauma">Heikki Kauma</name></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name></author><author><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14514639</idno><idno type="pmid">14514639</idno><idno type="wicri:Area/PubMed/Corpus">000577</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes.</title><author><name sortKey="Poykko, Seppo M" sort="Poykko, Seppo M" uniqKey="Poykko S" first="Seppo M" last="Pöykkö">Seppo M. 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We therefore assessed the hypothesis that a low ghrelin concentration may be a risk factor for type 2 diabetes and hypertension. We also characterized the effect of the ghrelin Arg51Gln and Leu72Met mutations on ghrelin concentrations in the population-based hypertensive (n = 519) and control (n = 526) cohorts of our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study. The fasting plasma ghrelin concentrations of 1,040 subjects were analyzed using the radioimmunoassay method. Insulin sensitivity was assessed using the quantitative insulin sensitivity check index (QUICKI). Ghrelin concentrations were negatively associated with fasting insulin (P < 0.001), systolic (P = 0.026) and diastolic BP (P = 0.018), and the prevalence of type 2 diabetes (P = 0.015) and insulin resistance (P < 0.001) in the multivariate models. In the control cohort, low ghrelin was associated with hypertension (BP >140/90 mmHg) (P = 0.031). The subjects with the ghrelin 51Gln allele had lower ghrelin concentrations than the Arg51Arg homozygotes (P = 0.001). We conclude that low ghrelin is independently associated with type 2 diabetes, insulin concentration, insulin resistance, and elevated BP. Therefore, it might have some role in the etiology of type 2 diabetes and the regulation of BP. The ghrelin Arg51Gln mutation is associated with low plasma ghrelin concentrations.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">14514639</PMID><DateCreated><Year>2003</Year><Month>09</Month><Day>29</Day></DateCreated><DateCompleted><Year>2003</Year><Month>12</Month><Day>03</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0012-1797</ISSN><JournalIssue CitedMedium="Print"><Volume>52</Volume><Issue>10</Issue><PubDate><Year>2003</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Diabetes</Title><ISOAbbreviation>Diabetes</ISOAbbreviation></Journal><ArticleTitle>Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes.</ArticleTitle><Pagination><MedlinePgn>2546-53</MedlinePgn></Pagination><Abstract><AbstractText>Experimental studies have suggested that ghrelin plays a role in glucose homeostasis and in the regulation of blood pressure (BP). We therefore assessed the hypothesis that a low ghrelin concentration may be a risk factor for type 2 diabetes and hypertension. We also characterized the effect of the ghrelin Arg51Gln and Leu72Met mutations on ghrelin concentrations in the population-based hypertensive (n = 519) and control (n = 526) cohorts of our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study. The fasting plasma ghrelin concentrations of 1,040 subjects were analyzed using the radioimmunoassay method. Insulin sensitivity was assessed using the quantitative insulin sensitivity check index (QUICKI). Ghrelin concentrations were negatively associated with fasting insulin (P < 0.001), systolic (P = 0.026) and diastolic BP (P = 0.018), and the prevalence of type 2 diabetes (P = 0.015) and insulin resistance (P < 0.001) in the multivariate models. In the control cohort, low ghrelin was associated with hypertension (BP >140/90 mmHg) (P = 0.031). The subjects with the ghrelin 51Gln allele had lower ghrelin concentrations than the Arg51Arg homozygotes (P = 0.001). We conclude that low ghrelin is independently associated with type 2 diabetes, insulin concentration, insulin resistance, and elevated BP. Therefore, it might have some role in the etiology of type 2 diabetes and the regulation of BP. The ghrelin Arg51Gln mutation is associated with low plasma ghrelin concentrations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pöykkö</LastName><ForeName>Seppo M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. seppo.poykko@ppshp.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kellokoski</LastName><ForeName>Eija</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Hörkkö</LastName><ForeName>Sohvi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kauma</LastName><ForeName>Heikki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kesäniemi</LastName><ForeName>Y Antero</ForeName><Initials>YA</Initials></Author><Author ValidYN="Y"><LastName>Ukkola</LastName><ForeName>Olavi</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Diabetes</MedlineTA><NlmUniqueID>0372763</NlmUniqueID><ISSNLinking>0012-1797</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054439">Ghrelin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D036361">Peptide Hormones</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003924">Diabetes Mellitus, Type 2</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D005387">Finland</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D054439">Ghrelin</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006973">Hypertension</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007333">Insulin Resistance</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009154">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009994">Osmolar Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D036361">Peptide Hormones</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015995">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>9</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>12</Month><Day>4</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>9</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14514639</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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