Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.
Identifieur interne : 000412 ( PubMed/Corpus ); précédent : 000411; suivant : 000413Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.
Auteurs : Tiia Kangas-Kontio ; Jari M. Tapanainen ; Heikki Huikuri ; Eeva-Riitta Savolainen ; Markku P Iv Nsalo ; Heikki Kauma ; Y Antero Kes Niemi ; Markku J. Savolainen ; Sakari KakkoSource :
- Scandinavian journal of clinical and laboratory investigation ; 2009.
English descriptors
- KwdEn :
- Adult, Atherosclerosis (genetics), Atherosclerosis (pathology), Carotid Arteries (ultrasonography), Cohort Studies, Coronary Artery Disease (genetics), Coronary Artery Disease (pathology), Female, Gene Frequency, Haplotypes, Humans, Male, Middle Aged, Myocardial Infarction (genetics), Polymorphism, Single Nucleotide, Risk Factors, Tunica Intima (ultrasonography), Tunica Media (ultrasonography), Vascular Endothelial Growth Factor A (genetics).
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor A.
- genetics : Atherosclerosis, Coronary Artery Disease, Myocardial Infarction.
- pathology : Atherosclerosis, Coronary Artery Disease.
- ultrasonography : Carotid Arteries, Tunica Intima, Tunica Media.
- Adult, Cohort Studies, Female, Gene Frequency, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
Abstract
Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor, but its role in atherogenesis is still unclear. Our goal was to study whether three variants of the VEGF gene, previously associated with VEGF production, are linked to atherosclerosis defined as carotid intima-media thickness (IMT) and as the risk of acute myocardial infarction (AMI).
DOI: 10.1080/00365510802607520
PubMed: 19089753
Links to Exploration step
pubmed:19089753Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.</title><author><name sortKey="Kangas Kontio, Tiia" sort="Kangas Kontio, Tiia" uniqKey="Kangas Kontio T" first="Tiia" last="Kangas-Kontio">Tiia Kangas-Kontio</name><affiliation><nlm:affiliation>Institute of Clinical Medicine, Department of Internal Medicine, Oulu University Hospital and Biocenter Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Tapanainen, Jari M" sort="Tapanainen, Jari M" uniqKey="Tapanainen J" first="Jari M" last="Tapanainen">Jari M. Tapanainen</name></author><author><name sortKey="Huikuri, Heikki" sort="Huikuri, Heikki" uniqKey="Huikuri H" first="Heikki" last="Huikuri">Heikki Huikuri</name></author><author><name sortKey="Savolainen, Eeva Riitta" sort="Savolainen, Eeva Riitta" uniqKey="Savolainen E" first="Eeva-Riitta" last="Savolainen">Eeva-Riitta Savolainen</name></author><author><name sortKey="P Iv Nsalo, Markku" sort="P Iv Nsalo, Markku" uniqKey="P Iv Nsalo M" first="Markku" last="P Iv Nsalo">Markku P Iv Nsalo</name></author><author><name sortKey="Kauma, Heikki" sort="Kauma, Heikki" uniqKey="Kauma H" first="Heikki" last="Kauma">Heikki Kauma</name></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J" last="Savolainen">Markku J. Savolainen</name></author><author><name sortKey="Kakko, Sakari" sort="Kakko, Sakari" uniqKey="Kakko S" first="Sakari" last="Kakko">Sakari Kakko</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1080/00365510802607520</idno><idno type="RBID">pubmed:19089753</idno><idno type="pmid">19089753</idno><idno type="wicri:Area/PubMed/Corpus">000412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.</title><author><name sortKey="Kangas Kontio, Tiia" sort="Kangas Kontio, Tiia" uniqKey="Kangas Kontio T" first="Tiia" last="Kangas-Kontio">Tiia Kangas-Kontio</name><affiliation><nlm:affiliation>Institute of Clinical Medicine, Department of Internal Medicine, Oulu University Hospital and Biocenter Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Tapanainen, Jari M" sort="Tapanainen, Jari M" uniqKey="Tapanainen J" first="Jari M" last="Tapanainen">Jari M. Tapanainen</name></author><author><name sortKey="Huikuri, Heikki" sort="Huikuri, Heikki" uniqKey="Huikuri H" first="Heikki" last="Huikuri">Heikki Huikuri</name></author><author><name sortKey="Savolainen, Eeva Riitta" sort="Savolainen, Eeva Riitta" uniqKey="Savolainen E" first="Eeva-Riitta" last="Savolainen">Eeva-Riitta Savolainen</name></author><author><name sortKey="P Iv Nsalo, Markku" sort="P Iv Nsalo, Markku" uniqKey="P Iv Nsalo M" first="Markku" last="P Iv Nsalo">Markku P Iv Nsalo</name></author><author><name sortKey="Kauma, Heikki" sort="Kauma, Heikki" uniqKey="Kauma H" first="Heikki" last="Kauma">Heikki Kauma</name></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J" last="Savolainen">Markku J. Savolainen</name></author><author><name sortKey="Kakko, Sakari" sort="Kakko, Sakari" uniqKey="Kakko S" first="Sakari" last="Kakko">Sakari Kakko</name></author></analytic><series><title level="j">Scandinavian journal of clinical and laboratory investigation</title><idno type="e-ISSN">1502-7686</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Atherosclerosis (genetics)</term><term>Atherosclerosis (pathology)</term><term>Carotid Arteries (ultrasonography)</term><term>Cohort Studies</term><term>Coronary Artery Disease (genetics)</term><term>Coronary Artery Disease (pathology)</term><term>Female</term><term>Gene Frequency</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Myocardial Infarction (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Tunica Intima (ultrasonography)</term><term>Tunica Media (ultrasonography)</term><term>Vascular Endothelial Growth Factor A (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Atherosclerosis</term><term>Coronary Artery Disease</term><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atherosclerosis</term><term>Coronary Artery Disease</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Carotid Arteries</term><term>Tunica Intima</term><term>Tunica Media</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Gene Frequency</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor, but its role in atherogenesis is still unclear. Our goal was to study whether three variants of the VEGF gene, previously associated with VEGF production, are linked to atherosclerosis defined as carotid intima-media thickness (IMT) and as the risk of acute myocardial infarction (AMI).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19089753</PMID><DateCreated><Year>2009</Year><Month>03</Month><Day>30</Day></DateCreated><DateCompleted><Year>2009</Year><Month>07</Month><Day>07</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1502-7686</ISSN><JournalIssue CitedMedium="Internet"><Volume>69</Volume><Issue>3</Issue><PubDate><Year>2009</Year></PubDate></JournalIssue><Title>Scandinavian journal of clinical and laboratory investigation</Title><ISOAbbreviation>Scand. J. Clin. Lab. Invest.</ISOAbbreviation></Journal><ArticleTitle>Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.</ArticleTitle><Pagination><MedlinePgn>335-43</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00365510802607520</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor, but its role in atherogenesis is still unclear. Our goal was to study whether three variants of the VEGF gene, previously associated with VEGF production, are linked to atherosclerosis defined as carotid intima-media thickness (IMT) and as the risk of acute myocardial infarction (AMI).</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Three VEGF gene single nucleotide polymorphisms (SNPs) (-2578A>C rs699947, -634C>G rs2010963 and +936C>T rs3025039) were genotyped in 516 control subjects of the OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort and in 251 survivors of AMI. In the OPERA cohort, the genotyped SNPs were analysed for their association with IMT. The SNPs were also analysed for their association with the risk of AMI, a complication of advanced atherosclerosis. In addition, haplotype frequencies and their associated effects on IMT and on the risk of AMI were estimated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">None of the single genotyped polymorphisms was significantly associated with overall IMT or with the risk of AMI. However, the haplotype CCC was associated with higher overall IMT without plaques in women (p = 0.01, haplotypic effect +0.03 mm), the haplotype CCT with higher IMT without plaques in the internal carotid artery in men (p = 0.001, +0.11), while the haplotype AGT was associated with reduced AMI risk (p = 0.015, OR = 0.46).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Variation in the VEGF gene is weakly associated with IMT and the risk of AMI, but the effect can only be observed when the information of the SNPs is combined by constructing haplotypes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kangas-Kontio</LastName><ForeName>Tiia</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Department of Internal Medicine, Oulu University Hospital and Biocenter Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tapanainen</LastName><ForeName>Jari M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Huikuri</LastName><ForeName>Heikki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Savolainen</LastName><ForeName>Eeva-Riitta</ForeName><Initials>ER</Initials></Author><Author ValidYN="Y"><LastName>Päivänsalo</LastName><ForeName>Markku</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kauma</LastName><ForeName>Heikki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kesäniemi</LastName><ForeName>Y Antero</ForeName><Initials>YA</Initials></Author><Author ValidYN="Y"><LastName>Savolainen</LastName><ForeName>Markku J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Kakko</LastName><ForeName>Sakari</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Norway</Country><MedlineTA>Scand J Clin Lab Invest</MedlineTA><NlmUniqueID>0404375</NlmUniqueID><ISSNLinking>0036-5513</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C467484">VEGFA protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050197">Atherosclerosis</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002339">Carotid Arteries</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003324">Coronary Artery Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005787">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006239">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009203">Myocardial Infarction</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017539">Tunica Intima</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017540">Tunica Media</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D042461">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>12</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>12</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>7</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">906848847</ArticleId><ArticleId IdType="doi">10.1080/00365510802607520</ArticleId><ArticleId IdType="pubmed">19089753</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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