Acoustic characterization and contrast imaging of microbubbles encapsulated by polymeric shells coated or filled with magnetic nanoparticles.
Identifieur interne : 000235 ( PubMed/Checkpoint ); précédent : 000234; suivant : 000236Acoustic characterization and contrast imaging of microbubbles encapsulated by polymeric shells coated or filled with magnetic nanoparticles.
Auteurs : Claudia Sciallero [Italie] ; Dmitry Grishenkov ; Satya V V N. Kothapalli ; Letizia Oddo ; Andrea TruccoSource :
- The Journal of the Acoustical Society of America ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Contrast Media, Magnetite Nanoparticles, Polyvinyl Alcohol.
- instrumentation : Magnetic Resonance Imaging, Ultrasonography.
- Acoustics, Microbubbles, Nonlinear Dynamics, Phantoms, Imaging, Pressure, Scattering, Radiation.
Abstract
The combination of superparamagnetic iron oxide nanoparticles with polymeric air-filled microbubbles is used to produce two types of multimodal contrast agents to enhance medical ultrasound and magnetic resonance imaging. The nanoparticles are either covalently linked to the shell or physically entrapped into the shell. In this paper, the characterization of the acoustic properties (backscattered power, fracturing pressure, attenuation and dispersion of the ultrasonic wave) and ultrasound imaging of the two types of magnetic microbubbles are presented. In vitro B-mode images are generated using a medical ultrasound scanner by applying a nonconventional signal processing technique that is suitable to detect polymeric bubbles and based on the combination of multipulse excitation and chirp coding. Even if both types of microbubbles can be considered to be effective ultrasound contrast agents, the different structure of the shell loaded with nanoparticles has a pronounced effect on the echogenicity and the detection sensitivity of the imaging technique. The best results are obtained using microbubbles that are externally coated with nanoparticles. A backscattered power of 20 dB was achieved at lower concentration, and an increment of 8 dB in the contrast-to-tissue ratio was observed with respect to the more rigid microbubbles with particles entrapped into the shell.
DOI: 10.1121/1.4824337
PubMed: 24180801
Affiliations:
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Kothapalli</name></author><author><name sortKey="Oddo, Letizia" sort="Oddo, Letizia" uniqKey="Oddo L" first="Letizia" last="Oddo">Letizia Oddo</name></author><author><name sortKey="Trucco, Andrea" sort="Trucco, Andrea" uniqKey="Trucco A" first="Andrea" last="Trucco">Andrea Trucco</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1121/1.4824337</idno><idno type="RBID">pubmed:24180801</idno><idno type="pmid">24180801</idno><idno type="wicri:Area/PubMed/Corpus">000198</idno><idno type="wicri:Area/PubMed/Curation">000198</idno><idno type="wicri:Area/PubMed/Checkpoint">000235</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Acoustic characterization and contrast imaging of microbubbles encapsulated by polymeric shells coated or filled with magnetic nanoparticles.</title><author><name sortKey="Sciallero, Claudia" sort="Sciallero, Claudia" uniqKey="Sciallero C" first="Claudia" last="Sciallero">Claudia Sciallero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electrical, Electronic, Telecommunication Engineering and Naval Architecture, University of Genoa, Via Opera Pia 11, 16145 Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Electrical, Electronic, Telecommunication Engineering and Naval Architecture, University of Genoa, Via Opera Pia 11, 16145 Genoa</wicri:regionArea><wicri:noRegion>16145 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Grishenkov, Dmitry" sort="Grishenkov, Dmitry" uniqKey="Grishenkov D" first="Dmitry" last="Grishenkov">Dmitry Grishenkov</name></author><author><name sortKey="Kothapalli, Satya V V N" sort="Kothapalli, Satya V V N" uniqKey="Kothapalli S" first="Satya V V N" last="Kothapalli">Satya V V N. Kothapalli</name></author><author><name sortKey="Oddo, Letizia" sort="Oddo, Letizia" uniqKey="Oddo L" first="Letizia" last="Oddo">Letizia Oddo</name></author><author><name sortKey="Trucco, Andrea" sort="Trucco, Andrea" uniqKey="Trucco A" first="Andrea" last="Trucco">Andrea Trucco</name></author></analytic><series><title level="j">The Journal of the Acoustical Society of America</title><idno type="e-ISSN">1520-8524</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustics</term><term>Contrast Media (chemistry)</term><term>Magnetic Resonance Imaging (instrumentation)</term><term>Magnetite Nanoparticles (chemistry)</term><term>Microbubbles</term><term>Nonlinear Dynamics</term><term>Phantoms, Imaging</term><term>Polyvinyl Alcohol (chemistry)</term><term>Pressure</term><term>Scattering, Radiation</term><term>Ultrasonography (instrumentation)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Contrast Media</term><term>Magnetite Nanoparticles</term><term>Polyvinyl Alcohol</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Ultrasonography</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustics</term><term>Microbubbles</term><term>Nonlinear Dynamics</term><term>Phantoms, Imaging</term><term>Pressure</term><term>Scattering, Radiation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The combination of superparamagnetic iron oxide nanoparticles with polymeric air-filled microbubbles is used to produce two types of multimodal contrast agents to enhance medical ultrasound and magnetic resonance imaging. The nanoparticles are either covalently linked to the shell or physically entrapped into the shell. In this paper, the characterization of the acoustic properties (backscattered power, fracturing pressure, attenuation and dispersion of the ultrasonic wave) and ultrasound imaging of the two types of magnetic microbubbles are presented. In vitro B-mode images are generated using a medical ultrasound scanner by applying a nonconventional signal processing technique that is suitable to detect polymeric bubbles and based on the combination of multipulse excitation and chirp coding. Even if both types of microbubbles can be considered to be effective ultrasound contrast agents, the different structure of the shell loaded with nanoparticles has a pronounced effect on the echogenicity and the detection sensitivity of the imaging technique. The best results are obtained using microbubbles that are externally coated with nanoparticles. A backscattered power of 20 dB was achieved at lower concentration, and an increment of 8 dB in the contrast-to-tissue ratio was observed with respect to the more rigid microbubbles with particles entrapped into the shell.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24180801</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>07</Month><Day>21</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1520-8524</ISSN><JournalIssue CitedMedium="Internet"><Volume>134</Volume><Issue>5</Issue><PubDate><Year>2013</Year><Month>Nov</Month></PubDate></JournalIssue><Title>The Journal of the Acoustical Society of America</Title><ISOAbbreviation>J. Acoust. Soc. Am.</ISOAbbreviation></Journal><ArticleTitle>Acoustic characterization and contrast imaging of microbubbles encapsulated by polymeric shells coated or filled with magnetic nanoparticles.</ArticleTitle><Pagination><MedlinePgn>3918-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1121/1.4824337</ELocationID><Abstract><AbstractText>The combination of superparamagnetic iron oxide nanoparticles with polymeric air-filled microbubbles is used to produce two types of multimodal contrast agents to enhance medical ultrasound and magnetic resonance imaging. The nanoparticles are either covalently linked to the shell or physically entrapped into the shell. In this paper, the characterization of the acoustic properties (backscattered power, fracturing pressure, attenuation and dispersion of the ultrasonic wave) and ultrasound imaging of the two types of magnetic microbubbles are presented. In vitro B-mode images are generated using a medical ultrasound scanner by applying a nonconventional signal processing technique that is suitable to detect polymeric bubbles and based on the combination of multipulse excitation and chirp coding. Even if both types of microbubbles can be considered to be effective ultrasound contrast agents, the different structure of the shell loaded with nanoparticles has a pronounced effect on the echogenicity and the detection sensitivity of the imaging technique. The best results are obtained using microbubbles that are externally coated with nanoparticles. A backscattered power of 20 dB was achieved at lower concentration, and an increment of 8 dB in the contrast-to-tissue ratio was observed with respect to the more rigid microbubbles with particles entrapped into the shell.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sciallero</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Electrical, Electronic, Telecommunication Engineering and Naval Architecture, University of Genoa, Via Opera Pia 11, 16145 Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grishenkov</LastName><ForeName>Dmitry</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Kothapalli</LastName><ForeName>Satya V V N</ForeName><Initials>SV</Initials></Author><Author ValidYN="Y"><LastName>Oddo</LastName><ForeName>Letizia</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Trucco</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Acoust Soc Am</MedlineTA><NlmUniqueID>7503051</NlmUniqueID><ISSNLinking>0001-4966</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003287">Contrast Media</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D058185">Magnetite Nanoparticles</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-89-5</RegistryNumber><NameOfSubstance UI="D011142">Polyvinyl Alcohol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D000162">Acoustics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003287">Contrast Media</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D058185">Magnetite Nanoparticles</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D045423">Microbubbles</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017711">Nonlinear Dynamics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019047">Phantoms, Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011142">Polyvinyl Alcohol</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011312">Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012542">Scattering, Radiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D014463">Ultrasonography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1121/1.4824337</ArticleId><ArticleId IdType="pubmed">24180801</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Grishenkov, Dmitry" sort="Grishenkov, Dmitry" uniqKey="Grishenkov D" first="Dmitry" last="Grishenkov">Dmitry Grishenkov</name><name sortKey="Kothapalli, Satya V V N" sort="Kothapalli, Satya V V N" uniqKey="Kothapalli S" first="Satya V V N" last="Kothapalli">Satya V V N. Kothapalli</name><name sortKey="Oddo, Letizia" sort="Oddo, Letizia" uniqKey="Oddo L" first="Letizia" last="Oddo">Letizia Oddo</name><name sortKey="Trucco, Andrea" sort="Trucco, Andrea" uniqKey="Trucco A" first="Andrea" last="Trucco">Andrea Trucco</name></noCountry><country name="Italie"><noRegion><name sortKey="Sciallero, Claudia" sort="Sciallero, Claudia" uniqKey="Sciallero C" first="Claudia" last="Sciallero">Claudia Sciallero</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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