Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.
Identifieur interne : 000809 ( Ncbi/Checkpoint ); précédent : 000808; suivant : 000810Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.
Auteurs : Meiju Saukko [Finlande] ; Y Antero Kes Niemi ; Olavi UkkolaSource :
- Metabolic syndrome and related disorders ; 2010.
English descriptors
- KwdEn :
- Adipocytes (cytology), Arginine (chemistry), Atherosclerosis (blood), Atherosclerosis (genetics), Blood Pressure, Body Mass Index, Endothelial Cells (cytology), Female, Glutamine (chemistry), Humans, Leptin (blood), Male, Middle Aged, Models, Genetic, Polymorphism, Genetic, Random Allocation, Receptors, Leptin (chemistry), Risk Factors.
- MESH :
- chemical , blood : Leptin.
- chemical , chemistry : Arginine, Glutamine, Receptors, Leptin.
- blood : Atherosclerosis.
- cytology : Adipocytes, Endothelial Cells.
- genetics : Atherosclerosis.
- Blood Pressure, Body Mass Index, Female, Humans, Male, Middle Aged, Models, Genetic, Polymorphism, Genetic, Random Allocation, Risk Factors.
Abstract
Leptin is a hormone expressed by the leptin gene, primarily in adipocytes, controlling food intake and energy expenditure. The effects of leptin are mediated by its receptor (LEPR) located in the central nervous system and other tissues, including adipocytes and endothelial cells. The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before.
DOI: 10.1089/met.2010.0004
PubMed: 20874424
Affiliations:
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pubmed:20874424Le document en format XML
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The effects of leptin are mediated by its receptor (LEPR) located in the central nervous system and other tissues, including adipocytes and endothelial cells. The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name></noCountry><country name="Finlande"><noRegion><name sortKey="Saukko, Meiju" sort="Saukko, Meiju" uniqKey="Saukko M" first="Meiju" last="Saukko">Meiju Saukko</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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