Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.
Identifieur interne : 000344 ( PubMed/Checkpoint ); précédent : 000343; suivant : 000345Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.
Auteurs : Meiju Saukko [Finlande] ; Y Antero Kes Niemi ; Olavi UkkolaSource :
- Metabolic syndrome and related disorders ; 2010.
English descriptors
- KwdEn :
- Adipocytes (cytology), Arginine (chemistry), Atherosclerosis (blood), Atherosclerosis (genetics), Blood Pressure, Body Mass Index, Endothelial Cells (cytology), Female, Glutamine (chemistry), Humans, Leptin (blood), Male, Middle Aged, Models, Genetic, Polymorphism, Genetic, Random Allocation, Receptors, Leptin (chemistry), Risk Factors.
- MESH :
- chemical , blood : Leptin.
- chemical , chemistry : Arginine, Glutamine, Receptors, Leptin.
- blood : Atherosclerosis.
- cytology : Adipocytes, Endothelial Cells.
- genetics : Atherosclerosis.
- Blood Pressure, Body Mass Index, Female, Humans, Male, Middle Aged, Models, Genetic, Polymorphism, Genetic, Random Allocation, Risk Factors.
Abstract
Leptin is a hormone expressed by the leptin gene, primarily in adipocytes, controlling food intake and energy expenditure. The effects of leptin are mediated by its receptor (LEPR) located in the central nervous system and other tissues, including adipocytes and endothelial cells. The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before.
DOI: 10.1089/met.2010.0004
PubMed: 20874424
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.</title><author><name sortKey="Saukko, Meiju" sort="Saukko, Meiju" uniqKey="Saukko M" first="Meiju" last="Saukko">Meiju Saukko</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name></author><author><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1089/met.2010.0004</idno><idno type="RBID">pubmed:20874424</idno><idno type="pmid">20874424</idno><idno type="wicri:Area/PubMed/Corpus">000344</idno><idno type="wicri:Area/PubMed/Curation">000344</idno><idno type="wicri:Area/PubMed/Checkpoint">000344</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.</title><author><name sortKey="Saukko, Meiju" sort="Saukko, Meiju" uniqKey="Saukko M" first="Meiju" last="Saukko">Meiju Saukko</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name></author><author><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name></author></analytic><series><title level="j">Metabolic syndrome and related disorders</title><idno type="e-ISSN">1557-8518</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipocytes (cytology)</term><term>Arginine (chemistry)</term><term>Atherosclerosis (blood)</term><term>Atherosclerosis (genetics)</term><term>Blood Pressure</term><term>Body Mass Index</term><term>Endothelial Cells (cytology)</term><term>Female</term><term>Glutamine (chemistry)</term><term>Humans</term><term>Leptin (blood)</term><term>Male</term><term>Middle Aged</term><term>Models, Genetic</term><term>Polymorphism, Genetic</term><term>Random Allocation</term><term>Receptors, Leptin (chemistry)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Leptin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Arginine</term><term>Glutamine</term><term>Receptors, Leptin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Adipocytes</term><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blood Pressure</term><term>Body Mass Index</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Genetic</term><term>Polymorphism, Genetic</term><term>Random Allocation</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Leptin is a hormone expressed by the leptin gene, primarily in adipocytes, controlling food intake and energy expenditure. The effects of leptin are mediated by its receptor (LEPR) located in the central nervous system and other tissues, including adipocytes and endothelial cells. The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20874424</PMID><DateCreated><Year>2010</Year><Month>10</Month><Day>14</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1557-8518</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Metabolic syndrome and related disorders</Title><ISOAbbreviation>Metab Syndr Relat Disord</ISOAbbreviation></Journal><ArticleTitle>Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.</ArticleTitle><Pagination><MedlinePgn>425-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/met.2010.0004</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Leptin is a hormone expressed by the leptin gene, primarily in adipocytes, controlling food intake and energy expenditure. The effects of leptin are mediated by its receptor (LEPR) located in the central nervous system and other tissues, including adipocytes and endothelial cells. The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This study was performed in the randomly selected, middle-aged control subjects (n=526) from our well-defined OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study. Analysis of covariance (ANCOVA) was performed to study the associations between genotypes, intima media thickness (IMT) measurements, and risk factors for atherosclerosis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Subjects with the genotype Lys109Arg had the lowest body mass index (BMI) (P = 0.035), whereas Arg109Arg homozygotes had the highest total cholesterol (P=0.021) when adjusted for sex and age. Gln223Arg associated independently with systolic blood pressure (P=0.036). There were no differences in leptin concentrations between the genotypes. The adjusted (sex, age, BMI, smoking status, low-density lipoprotein cholesterol, systolic blood pressure, and fasting blood glucose) means for the IMT measurements were lowest in the Arg109 and Arg223 homozygotes (P=0.042 and P=0.041, ANCOVA, respectively).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The variations in the LEPR gene are independently associated with early atherosclerosis and some of its risk factors. These variations could possibly affect leptin signaling and thereby modify the effects of leptin on the atherosclerotic process.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saukko</LastName><ForeName>Meiju</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kesäniemi</LastName><ForeName>Y Antero</ForeName><Initials>YA</Initials></Author><Author ValidYN="Y"><LastName>Ukkola</LastName><ForeName>Olavi</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Metab Syndr Relat Disord</MedlineTA><NlmUniqueID>101150318</NlmUniqueID><ISSNLinking>1540-4196</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020738">Leptin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054411">Receptors, Leptin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0RH81L854J</RegistryNumber><NameOfSubstance UI="D005973">Glutamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>94ZLA3W45F</RegistryNumber><NameOfSubstance UI="D001120">Arginine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017667">Adipocytes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001120">Arginine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050197">Atherosclerosis</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001794">Blood Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015992">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D042783">Endothelial Cells</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005973">Glutamine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020738">Leptin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008957">Models, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011110">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011897">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D054411">Receptors, Leptin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1089/met.2010.0004</ArticleId><ArticleId IdType="pubmed">20874424</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name></noCountry><country name="Finlande"><noRegion><name sortKey="Saukko, Meiju" sort="Saukko, Meiju" uniqKey="Saukko M" first="Meiju" last="Saukko">Meiju Saukko</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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