Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.
Identifieur interne : 000B00 ( Main/Curation ); précédent : 000A99; suivant : 000B01Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.
Auteurs : N M Surina [Russie] ; T S Kalinina ; A V Volkova ; L A Malikova ; I I Poletaeva ; K S Rayevsky ; I B FedotovaSource :
- Bulletin of experimental biology and medicine ; 2011.
English descriptors
- KwdEn :
- Animals, Anti-Anxiety Agents (administration & dosage), Anti-Anxiety Agents (therapeutic use), Anticonvulsants (administration & dosage), Anticonvulsants (therapeutic use), Anxiety (complications), Anxiety (drug therapy), Anxiety (genetics), Anxiety (physiopathology), Benzimidazoles (administration & dosage), Benzimidazoles (therapeutic use), Epilepsy, Reflex (complications), Epilepsy, Reflex (drug therapy), Epilepsy, Reflex (genetics), Epilepsy, Reflex (physiopathology), Genetic Predisposition to Disease, Injections, Intraperitoneal, Male, Maze Learning (drug effects), Morpholines (administration & dosage), Morpholines (therapeutic use), Motor Activity (drug effects), Piracetam (administration & dosage), Piracetam (analogs & derivatives), Piracetam (therapeutic use), Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Wistar, Severity of Illness Index.
- MESH :
- chemical , administration & dosage : Anti-Anxiety Agents, Anticonvulsants, Benzimidazoles, Morpholines, Piracetam.
- chemical , analogs & derivatives : Piracetam.
- chemical , therapeutic use : Anti-Anxiety Agents, Anticonvulsants, Benzimidazoles, Morpholines, Piracetam.
- complications : Anxiety, Epilepsy, Reflex.
- drug effects : Maze Learning, Motor Activity.
- drug therapy : Anxiety, Epilepsy, Reflex.
- genetics : Anxiety, Epilepsy, Reflex.
- physiopathology : Anxiety, Epilepsy, Reflex.
- Animals, Genetic Predisposition to Disease, Injections, Intraperitoneal, Male, Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Wistar, Severity of Illness Index.
Abstract
We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.
PubMed: 22442800
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<author><name sortKey="Volkova, A V" sort="Volkova, A V" uniqKey="Volkova A" first="A V" last="Volkova">A V Volkova</name>
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<series><title level="j">Bulletin of experimental biology and medicine</title>
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<term>Anticonvulsants (administration & dosage)</term>
<term>Anticonvulsants (therapeutic use)</term>
<term>Anxiety (complications)</term>
<term>Anxiety (drug therapy)</term>
<term>Anxiety (genetics)</term>
<term>Anxiety (physiopathology)</term>
<term>Benzimidazoles (administration & dosage)</term>
<term>Benzimidazoles (therapeutic use)</term>
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<term>Epilepsy, Reflex (drug therapy)</term>
<term>Epilepsy, Reflex (genetics)</term>
<term>Epilepsy, Reflex (physiopathology)</term>
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<term>Injections, Intraperitoneal</term>
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<term>Maze Learning (drug effects)</term>
<term>Morpholines (administration & dosage)</term>
<term>Morpholines (therapeutic use)</term>
<term>Motor Activity (drug effects)</term>
<term>Piracetam (administration & dosage)</term>
<term>Piracetam (analogs & derivatives)</term>
<term>Piracetam (therapeutic use)</term>
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<term>Rats, Wistar</term>
<term>Severity of Illness Index</term>
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<term>Anticonvulsants</term>
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<term>Epilepsy, Reflex</term>
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<term>Motor Activity</term>
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<term>Epilepsy, Reflex</term>
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<term>Epilepsy, Reflex</term>
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<term>Genetic Predisposition to Disease</term>
<term>Injections, Intraperitoneal</term>
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<term>Rats</term>
<term>Rats, Inbred Strains</term>
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<front><div type="abstract" xml:lang="en">We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.</div>
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