OperaV1, PubMed, Curation, bibRecord, 000277

Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.

Identifieur interne : 000277 ( PubMed/Curation ); précédent : 000276; suivant : 000278

Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.

Auteurs : N M Surina [Russie] ; T S Kalinina ; A V Volkova ; L A Malikova ; I I Poletaeva ; K S Rayevsky ; I B Fedotova

Source :

Bulletin of experimental biology and medicine ; 2011.

RBID : pubmed:22442800

English descriptors

KwdEn :
- Animals, Anti-Anxiety Agents (administration & dosage), Anti-Anxiety Agents (therapeutic use), Anticonvulsants (administration & dosage), Anticonvulsants (therapeutic use), Anxiety (complications), Anxiety (drug therapy), Anxiety (genetics), Anxiety (physiopathology), Benzimidazoles (administration & dosage), Benzimidazoles (therapeutic use), Epilepsy, Reflex (complications), Epilepsy, Reflex (drug therapy), Epilepsy, Reflex (genetics), Epilepsy, Reflex (physiopathology), Genetic Predisposition to Disease, Injections, Intraperitoneal, Male, Maze Learning (drug effects), Morpholines (administration & dosage), Morpholines (therapeutic use), Motor Activity (drug effects), Piracetam (administration & dosage), Piracetam (analogs & derivatives), Piracetam (therapeutic use), Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Wistar, Severity of Illness Index.
MESH :
- chemical , administration & dosage : Anti-Anxiety Agents, Anticonvulsants, Benzimidazoles, Morpholines, Piracetam.
- chemical , analogs & derivatives : Piracetam.
- chemical , therapeutic use : Anti-Anxiety Agents, Anticonvulsants, Benzimidazoles, Morpholines, Piracetam.
- complications : Anxiety, Epilepsy, Reflex.
- drug effects : Maze Learning, Motor Activity.
- drug therapy : Anxiety, Epilepsy, Reflex.
- genetics : Anxiety, Epilepsy, Reflex.
- physiopathology : Anxiety, Epilepsy, Reflex.
- Animals, Genetic Predisposition to Disease, Injections, Intraperitoneal, Male, Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Wistar, Severity of Illness Index.

Abstract

We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.

PubMed: 22442800

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Le document en format XML

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<author><name sortKey="Surina, N M" sort="Surina, N M" uniqKey="Surina N" first="N M" last="Surina">N M Surina</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. opera_ghost@inbox.ru</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Biological Faculty, M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea>
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<author><name sortKey="Kalinina, T S" sort="Kalinina, T S" uniqKey="Kalinina T" first="T S" last="Kalinina">T S Kalinina</name>
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<author><name sortKey="Volkova, A V" sort="Volkova, A V" uniqKey="Volkova A" first="A V" last="Volkova">A V Volkova</name>
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<author><name sortKey="Malikova, L A" sort="Malikova, L A" uniqKey="Malikova L" first="L A" last="Malikova">L A Malikova</name>
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<author><name sortKey="Poletaeva, I I" sort="Poletaeva, I I" uniqKey="Poletaeva I" first="I I" last="Poletaeva">I I Poletaeva</name>
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<author><name sortKey="Rayevsky, K S" sort="Rayevsky, K S" uniqKey="Rayevsky K" first="K S" last="Rayevsky">K S Rayevsky</name>
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<author><name sortKey="Fedotova, I B" sort="Fedotova, I B" uniqKey="Fedotova I" first="I B" last="Fedotova">I B Fedotova</name>
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<term>Anticonvulsants (administration & dosage)</term>
<term>Anticonvulsants (therapeutic use)</term>
<term>Anxiety (complications)</term>
<term>Anxiety (drug therapy)</term>
<term>Anxiety (genetics)</term>
<term>Anxiety (physiopathology)</term>
<term>Benzimidazoles (administration & dosage)</term>
<term>Benzimidazoles (therapeutic use)</term>
<term>Epilepsy, Reflex (complications)</term>
<term>Epilepsy, Reflex (drug therapy)</term>
<term>Epilepsy, Reflex (genetics)</term>
<term>Epilepsy, Reflex (physiopathology)</term>
<term>Genetic Predisposition to Disease</term>
<term>Injections, Intraperitoneal</term>
<term>Male</term>
<term>Maze Learning (drug effects)</term>
<term>Morpholines (administration & dosage)</term>
<term>Morpholines (therapeutic use)</term>
<term>Motor Activity (drug effects)</term>
<term>Piracetam (administration & dosage)</term>
<term>Piracetam (analogs & derivatives)</term>
<term>Piracetam (therapeutic use)</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Rats, Long-Evans</term>
<term>Rats, Wistar</term>
<term>Severity of Illness Index</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Anxiety Agents</term>
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<term>Morpholines</term>
<term>Piracetam</term>
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<term>Morpholines</term>
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<term>Epilepsy, Reflex</term>
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<term>Epilepsy, Reflex</term>
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<term>Epilepsy, Reflex</term>
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<term>Epilepsy, Reflex</term>
</keywords>
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<term>Genetic Predisposition to Disease</term>
<term>Injections, Intraperitoneal</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Rats, Long-Evans</term>
<term>Rats, Wistar</term>
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<front><div type="abstract" xml:lang="en">We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.</div>
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Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.

Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki