Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.
Identifieur interne : 000787 ( Main/Curation ); précédent : 000786; suivant : 000788Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.
Auteurs : M. Uchiyama [Japon] ; X. Jin ; Q. Zhang ; A. Amano ; T. Watanabe ; M. NiimiSource :
- Transplantation proceedings ; 2012.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adoptive Transfer, Animals, Cell Proliferation, Cytokines (metabolism), Flow Cytometry, Forkhead Transcription Factors (metabolism), Graft Rejection (immunology), Graft Rejection (prevention & control), Graft Survival, Heart Transplantation (immunology), Histocompatibility, Interleukin-2 Receptor alpha Subunit (metabolism), Lymphocyte Activation, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Music, Skin Transplantation (immunology), T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (transplantation), Time Factors, Tympanic Membrane Perforation (immunology), Tympanic Membrane Perforation (physiopathology).
- MESH :
- chemical , metabolism : Cytokines, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit.
- immunology : Graft Rejection, Heart Transplantation, Skin Transplantation, T-Lymphocytes, Regulatory, Tympanic Membrane Perforation.
- physiopathology : Tympanic Membrane Perforation.
- prevention & control : Graft Rejection.
- transplantation : T-Lymphocytes, Regulatory.
- Acoustic Stimulation, Adoptive Transfer, Animals, Cell Proliferation, Flow Cytometry, Graft Survival, Histocompatibility, Lymphocyte Activation, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Music, Time Factors.
Abstract
In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.
DOI: 10.1016/j.transproceed.2012.02.008
PubMed: 22564629
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000267
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000267
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000260
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000988
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000988
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000988
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000782
Links to Exploration step
pubmed:22564629Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.</title>
<author><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M" last="Uchiyama">M. Uchiyama</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X" last="Jin">X. Jin</name>
</author>
<author><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name>
</author>
<author><name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A" last="Amano">A. Amano</name>
</author>
<author><name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T" last="Watanabe">T. Watanabe</name>
</author>
<author><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M" last="Niimi">M. Niimi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="doi">10.1016/j.transproceed.2012.02.008</idno>
<idno type="RBID">pubmed:22564629</idno>
<idno type="pmid">22564629</idno>
<idno type="wicri:Area/PubMed/Corpus">000267</idno>
<idno type="wicri:Area/PubMed/Curation">000267</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000260</idno>
<idno type="wicri:Area/Ncbi/Merge">000988</idno>
<idno type="wicri:Area/Ncbi/Curation">000988</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000988</idno>
<idno type="wicri:Area/Main/Merge">000782</idno>
<idno type="wicri:Area/Main/Curation">000787</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.</title>
<author><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M" last="Uchiyama">M. Uchiyama</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X" last="Jin">X. Jin</name>
</author>
<author><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name>
</author>
<author><name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A" last="Amano">A. Amano</name>
</author>
<author><name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T" last="Watanabe">T. Watanabe</name>
</author>
<author><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M" last="Niimi">M. Niimi</name>
</author>
</analytic>
<series><title level="j">Transplantation proceedings</title>
<idno type="e-ISSN">1873-2623</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term>
<term>Adoptive Transfer</term>
<term>Animals</term>
<term>Cell Proliferation</term>
<term>Cytokines (metabolism)</term>
<term>Flow Cytometry</term>
<term>Forkhead Transcription Factors (metabolism)</term>
<term>Graft Rejection (immunology)</term>
<term>Graft Rejection (prevention & control)</term>
<term>Graft Survival</term>
<term>Heart Transplantation (immunology)</term>
<term>Histocompatibility</term>
<term>Interleukin-2 Receptor alpha Subunit (metabolism)</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Inbred CBA</term>
<term>Music</term>
<term>Skin Transplantation (immunology)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (transplantation)</term>
<term>Time Factors</term>
<term>Tympanic Membrane Perforation (immunology)</term>
<term>Tympanic Membrane Perforation (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Forkhead Transcription Factors</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Graft Rejection</term>
<term>Heart Transplantation</term>
<term>Skin Transplantation</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Tympanic Membrane Perforation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tympanic Membrane Perforation</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>T-Lymphocytes, Regulatory</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term>
<term>Adoptive Transfer</term>
<term>Animals</term>
<term>Cell Proliferation</term>
<term>Flow Cytometry</term>
<term>Graft Survival</term>
<term>Histocompatibility</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Inbred CBA</term>
<term>Music</term>
<term>Time Factors</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/OperaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000787 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000787 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Musique |area= OperaV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:22564629 |texte= Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:22564629" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a OperaV1
This area was generated with Dilib version V0.6.21. |