Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.
Identifieur interne : 000988 ( Ncbi/Merge ); précédent : 000987; suivant : 000989Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.
Auteurs : M. Uchiyama [Japon] ; X. Jin ; Q. Zhang ; A. Amano ; T. Watanabe ; M. NiimiSource :
- Transplantation proceedings ; 2012.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adoptive Transfer, Animals, Cell Proliferation, Cytokines (metabolism), Flow Cytometry, Forkhead Transcription Factors (metabolism), Graft Rejection (immunology), Graft Rejection (prevention & control), Graft Survival, Heart Transplantation (immunology), Histocompatibility, Interleukin-2 Receptor alpha Subunit (metabolism), Lymphocyte Activation, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Music, Skin Transplantation (immunology), T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (transplantation), Time Factors, Tympanic Membrane Perforation (immunology), Tympanic Membrane Perforation (physiopathology).
- MESH :
- chemical , metabolism : Cytokines, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit.
- immunology : Graft Rejection, Heart Transplantation, Skin Transplantation, T-Lymphocytes, Regulatory, Tympanic Membrane Perforation.
- physiopathology : Tympanic Membrane Perforation.
- prevention & control : Graft Rejection.
- transplantation : T-Lymphocytes, Regulatory.
- Acoustic Stimulation, Adoptive Transfer, Animals, Cell Proliferation, Flow Cytometry, Graft Survival, Histocompatibility, Lymphocyte Activation, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Music, Time Factors.
Abstract
In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.
DOI: 10.1016/j.transproceed.2012.02.008
PubMed: 22564629
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pubmed:22564629Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.</title><author><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M" last="Uchiyama">M. Uchiyama</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X" last="Jin">X. Jin</name></author><author><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name></author><author><name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A" last="Amano">A. Amano</name></author><author><name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T" last="Watanabe">T. Watanabe</name></author><author><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M" last="Niimi">M. Niimi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1016/j.transproceed.2012.02.008</idno><idno type="RBID">pubmed:22564629</idno><idno type="pmid">22564629</idno><idno type="wicri:Area/PubMed/Corpus">000267</idno><idno type="wicri:Area/PubMed/Curation">000267</idno><idno type="wicri:Area/PubMed/Checkpoint">000260</idno><idno type="wicri:Area/Ncbi/Merge">000988</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.</title><author><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M" last="Uchiyama">M. Uchiyama</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X" last="Jin">X. Jin</name></author><author><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name></author><author><name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A" last="Amano">A. Amano</name></author><author><name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T" last="Watanabe">T. Watanabe</name></author><author><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M" last="Niimi">M. Niimi</name></author></analytic><series><title level="j">Transplantation proceedings</title><idno type="e-ISSN">1873-2623</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adoptive Transfer</term><term>Animals</term><term>Cell Proliferation</term><term>Cytokines (metabolism)</term><term>Flow Cytometry</term><term>Forkhead Transcription Factors (metabolism)</term><term>Graft Rejection (immunology)</term><term>Graft Rejection (prevention & control)</term><term>Graft Survival</term><term>Heart Transplantation (immunology)</term><term>Histocompatibility</term><term>Interleukin-2 Receptor alpha Subunit (metabolism)</term><term>Lymphocyte Activation</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred CBA</term><term>Music</term><term>Skin Transplantation (immunology)</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>T-Lymphocytes, Regulatory (transplantation)</term><term>Time Factors</term><term>Tympanic Membrane Perforation (immunology)</term><term>Tympanic Membrane Perforation (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Forkhead Transcription Factors</term><term>Interleukin-2 Receptor alpha Subunit</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Graft Rejection</term><term>Heart Transplantation</term><term>Skin Transplantation</term><term>T-Lymphocytes, Regulatory</term><term>Tympanic Membrane Perforation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tympanic Membrane Perforation</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>T-Lymphocytes, Regulatory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adoptive Transfer</term><term>Animals</term><term>Cell Proliferation</term><term>Flow Cytometry</term><term>Graft Survival</term><term>Histocompatibility</term><term>Lymphocyte Activation</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred CBA</term><term>Music</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22564629</PMID><DateCreated><Year>2012</Year><Month>05</Month><Day>08</Day></DateCreated><DateCompleted><Year>2012</Year><Month>09</Month><Day>04</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1873-2623</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>May</Month></PubDate></JournalIssue><Title>Transplantation proceedings</Title><ISOAbbreviation>Transplant. Proc.</ISOAbbreviation></Journal><ArticleTitle>Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.</ArticleTitle><Pagination><MedlinePgn>1076-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.transproceed.2012.02.008</ELocationID><Abstract><AbstractText>In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Uchiyama</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>X</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Q</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Amano</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Niimi</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transplant Proc</MedlineTA><NlmUniqueID>0243532</NlmUniqueID><ISSNLinking>0041-1345</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051858">Forkhead Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C498833">Foxp3 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508018">Il2ra protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053645">Interleukin-2 Receptor alpha Subunit</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000161">Acoustic Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019264">Adoptive Transfer</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D049109">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016207">Cytokines</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005434">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051858">Forkhead Transcription Factors</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006084">Graft Rejection</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D006085">Graft Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016027">Heart Transplantation</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006648">Histocompatibility</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D053645">Interleukin-2 Receptor alpha Subunit</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008213">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008807">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008810">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008808">Mice, Inbred CBA</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009146">Music</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016038">Skin Transplantation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000276">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050378">T-Lymphocytes, Regulatory</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000637">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018058">Tympanic Membrane Perforation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0041-1345(12)00196-0</ArticleId><ArticleId IdType="doi">10.1016/j.transproceed.2012.02.008</ArticleId><ArticleId IdType="pubmed">22564629</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A" last="Amano">A. Amano</name><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X" last="Jin">X. Jin</name><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M" last="Niimi">M. Niimi</name><name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T" last="Watanabe">T. Watanabe</name><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name></noCountry><country name="Japon"><noRegion><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M" last="Uchiyama">M. Uchiyama</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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