Combining Non-Pharmacological Treatments with Pharmacotherapies for Neurological Disorders: A Unique Interface of the Brain, Drug–Device, and Intellectual Property
Identifieur interne : 000175 ( Main/Merge ); précédent : 000174; suivant : 000176Combining Non-Pharmacological Treatments with Pharmacotherapies for Neurological Disorders: A Unique Interface of the Brain, Drug–Device, and Intellectual Property
Auteurs : Grzegorz Bulaj [États-Unis]Source :
- Frontiers in Neurology ; 2014.
Abstract
Mobile medical applications (mHealth), music, and video games are being developed and tested for their ability to improve pharmacotherapy outcomes and medication adherence. Pleiotropic mechanism of music and gamification engages an intrinsic motivation and the brain reward system, supporting therapies in patients with neurological disorders, including neuropathic pain, depression, anxiety, or neurodegenerative disorders. Based on accumulating results from clinical trials, an innovative combination treatment of epilepsy seizures, comorbidities, and the medication non-adherence can be designed, consisting of antiepileptic drugs and disease self-management software delivering clinically beneficial music. Since creative elements and art expressed in games, music, and software are copyrighted, therefore clinical and regulatory challenges in developing copyrighted, drug–device therapies may be offset by a value proposition of the exclusivity due to the patent–independent protection, which can last for over 70 years. Taken together, development of copyrighted non-pharmacological treatments (e-therapies), and their combinations with pharmacotherapies, offer incentives to chronically ill patients and outcome-driven health care industries.
Url:
DOI: 10.3389/fneur.2014.00126
PubMed: 25071711
PubMed Central: 4095562
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combining Non-Pharmacological Treatments with Pharmacotherapies for Neurological Disorders: A Unique Interface of the Brain, Drug–Device, and Intellectual Property</title><author><name sortKey="Bulaj, Grzegorz" sort="Bulaj, Grzegorz" uniqKey="Bulaj G" first="Grzegorz" last="Bulaj">Grzegorz Bulaj</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medicinal Chemistry, Skaggs Pharmacy Institute, College of Pharmacy, University of Utah</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25071711</idno><idno type="pmc">4095562</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095562</idno><idno type="RBID">PMC:4095562</idno><idno type="doi">10.3389/fneur.2014.00126</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000832</idno><idno type="wicri:Area/Pmc/Curation">000832</idno><idno type="wicri:Area/Pmc/Checkpoint">000150</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000032</idno><idno type="wicri:Area/PubMed/Curation">000032</idno><idno type="wicri:Area/PubMed/Checkpoint">000038</idno><idno type="wicri:Area/Ncbi/Merge">000737</idno><idno type="wicri:Area/Ncbi/Curation">000737</idno><idno type="wicri:Area/Ncbi/Checkpoint">000737</idno><idno type="wicri:Area/Main/Merge">000175</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combining Non-Pharmacological Treatments with Pharmacotherapies for Neurological Disorders: A Unique Interface of the Brain, Drug–Device, and Intellectual Property</title><author><name sortKey="Bulaj, Grzegorz" sort="Bulaj, Grzegorz" uniqKey="Bulaj G" first="Grzegorz" last="Bulaj">Grzegorz Bulaj</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medicinal Chemistry, Skaggs Pharmacy Institute, College of Pharmacy, University of Utah</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neurology</title><idno type="e-ISSN">1664-2295</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mobile medical applications (mHealth), music, and video games are being developed and tested for their ability to improve pharmacotherapy outcomes and medication adherence. Pleiotropic mechanism of music and gamification engages an intrinsic motivation and the brain reward system, supporting therapies in patients with neurological disorders, including neuropathic pain, depression, anxiety, or neurodegenerative disorders. Based on accumulating results from clinical trials, an innovative combination treatment of epilepsy seizures, comorbidities, and the medication non-adherence can be designed, consisting of antiepileptic drugs and disease self-management software delivering clinically beneficial music. Since creative elements and art expressed in games, music, and software are copyrighted, therefore clinical and regulatory challenges in developing copyrighted, drug–device therapies may be offset by a value proposition of the exclusivity due to the patent–independent protection, which can last for over 70 years. Taken together, development of copyrighted non-pharmacological treatments (e-therapies), and their combinations with pharmacotherapies, offer incentives to chronically ill patients and outcome-driven health care industries.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Charani, E" uniqKey="Charani E">E Charani</name></author><author><name sortKey="Castro Sanchez, E" uniqKey="Castro Sanchez E">E Castro-Sanchez</name></author><author><name sortKey="Moore, Ls" uniqKey="Moore L">LS Moore</name></author><author><name sortKey="Holmes, A" uniqKey="Holmes A">A Holmes</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Jongh, T" uniqKey="De Jongh T">T de Jongh</name></author><author><name sortKey="Gurol Urganci, I" uniqKey="Gurol Urganci I">I Gurol-Urganci</name></author><author><name sortKey="Vodopivec Jamsek, V" uniqKey="Vodopivec Jamsek V">V 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sortKey="Abrams, S" uniqKey="Abrams S">S Abrams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Defulio, A" uniqKey="Defulio A">A DeFulio</name></author><author><name sortKey="Silverman, K" uniqKey="Silverman K">K Silverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brady, Tj" uniqKey="Brady T">TJ Brady</name></author><author><name sortKey="Murphy, L" uniqKey="Murphy L">L Murphy</name></author><author><name sortKey="Beauchesne, D" uniqKey="Beauchesne D">D Beauchesne</name></author><author><name sortKey="Bhalakia, A" uniqKey="Bhalakia A">A Bhalakia</name></author><author><name sortKey="Chervin, D" uniqKey="Chervin D">D Chervin</name></author><author><name sortKey="Daniels, B" uniqKey="Daniels B">B Daniels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, Hs" uniqKey="White H">HS White</name></author><author><name sortKey="Loscher, W" uniqKey="Loscher W">W Loscher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bucklen, Kw" uniqKey="Bucklen K">KW Bucklen</name></author><author><name sortKey="Abbott, Bm" uniqKey="Abbott B">BM Abbott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, R" uniqKey="Robinson R">R Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrison, C" uniqKey="Harrison C">C Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yetisen, Ak" uniqKey="Yetisen A">AK Yetisen</name></author><author><name sortKey="Martinez Hurtado, Jl" uniqKey="Martinez Hurtado J">JL Martinez-Hurtado</name></author><author><name sortKey="Da Cruz Vasconcellos, F" uniqKey="Da Cruz Vasconcellos F">F da Cruz Vasconcellos</name></author><author><name sortKey="Simsekler, Mc" uniqKey="Simsekler M">MC Simsekler</name></author><author><name sortKey="Akram, Ms" uniqKey="Akram M">MS Akram</name></author><author><name sortKey="Lowe, Cr" uniqKey="Lowe C">CR Lowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couto, Ds" uniqKey="Couto D">DS Couto</name></author><author><name sortKey="Perez Breva, L" uniqKey="Perez Breva L">L Perez-Breva</name></author><author><name sortKey="Saraiva, P" uniqKey="Saraiva P">P Saraiva</name></author><author><name sortKey="Cooney, Cl" uniqKey="Cooney C">CL Cooney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hupcey, Ma" uniqKey="Hupcey M">MA Hupcey</name></author><author><name sortKey="Ekins, S" uniqKey="Ekins S">S Ekins</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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