Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations.
Identifieur interne : 000041 ( Ncbi/Merge ); précédent : 000040; suivant : 000042Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations.
Auteurs : Simone Gabbanini [Italie] ; Riccardo Matera ; Claudia Beltramini ; Andrea Minghetti ; Luca ValgimigliSource :
- Journal of pharmaceutical and biomedical analysis [ 1873-264X ] ; 2010.
English descriptors
- KwdEn :
- Chemistry, Pharmaceutical (methods), Cosmetics (administration & dosage), Cosmetics (chemistry), Cosmetics (pharmacokinetics), Epidermis (drug effects), Epidermis (metabolism), Humans, Membranes, Artificial, Skin Absorption (drug effects), Skin Absorption (physiology), Vitamins (administration & dosage), Vitamins (chemistry), Vitamins (pharmacokinetics).
- MESH :
- chemical , administration & dosage : Cosmetics, Vitamins.
- chemical , chemistry : Cosmetics, Vitamins.
- drug effects : Epidermis, Skin Absorption.
- metabolism : Epidermis.
- methods : Chemistry, Pharmaceutical.
- chemical , pharmacokinetics : Cosmetics, Vitamins.
- physiology : Skin Absorption.
- Humans, Membranes, Artificial.
Abstract
A convenient method for in vitro investigation of the release of lipid- and water-soluble vitamins from cosmetic formulations was developed. The permeation of (d)-alpha-tocopherol (vitamin E), retinyl acetate (pro-vitamin A), ascorbic acid (vitamin C) and pyridoxine (vitamin B6) through SkinEthic reconstructed human epidermis (RHE), and synthetic polyethersulfone and polycarbonate membranes was studied in vitro using a Franz-type diffusion apparatus, coupled either to a spectrophotometer for continuous reading (dynamic setting) or to HPLC-DAD analysis of the receptor medium (static setting). O/W and W/O emulsions were compared with simple aqueous solutions for their kinetic of vitamins release, to evaluate the influence of the cosmetic formulation on the bioavailability of active ingredients. Results indicate that synthetic membranes offer a limited barrier to the diffusion of vitamins, but may provide information on the release ability of the formulation. Penetration was more effective when water was the external phase of the formulation, i.e. W/O emulsions were less effective in the release of vitamins than O/W emulsion or aqueous solutions. RHE (17 days old) offered a significantly higher barrier to penetration of vitamins, as expected for native human epidermis. The relative ranking in coefficient of permeability (Ps (cm/h)) was: ascorbic acid>pyridoxine>retinyl acetate>alpha-tocopherol approximately 0, the absolute values depending on the formulation. The method herein described showed to be a practical and convenient tool for the quality-control and efficacy evaluation of cosmetic formulations.
DOI: 10.1016/j.jpba.2010.01.029
PubMed: 20138453
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000023
- to stream PubMed, to step Curation: 000014
- to stream PubMed, to step Checkpoint: 000015
Links to Exploration step
pubmed:20138453Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations.</title><author><name sortKey="Gabbanini, Simone" sort="Gabbanini, Simone" uniqKey="Gabbanini S" first="Simone" last="Gabbanini">Simone Gabbanini</name><affiliation wicri:level="1"><nlm:affiliation>BeC S.r.l., R&D division, Via C. Monteverdi 49, 47100 Forlì, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>BeC S.r.l., R&D division, Via C. Monteverdi 49, 47100 Forlì</wicri:regionArea><wicri:noRegion>47100 Forlì</wicri:noRegion></affiliation></author><author><name sortKey="Matera, Riccardo" sort="Matera, Riccardo" uniqKey="Matera R" first="Riccardo" last="Matera">Riccardo Matera</name></author><author><name sortKey="Beltramini, Claudia" sort="Beltramini, Claudia" uniqKey="Beltramini C" first="Claudia" last="Beltramini">Claudia Beltramini</name></author><author><name sortKey="Minghetti, Andrea" sort="Minghetti, Andrea" uniqKey="Minghetti A" first="Andrea" last="Minghetti">Andrea Minghetti</name></author><author><name sortKey="Valgimigli, Luca" sort="Valgimigli, Luca" uniqKey="Valgimigli L" first="Luca" last="Valgimigli">Luca Valgimigli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1016/j.jpba.2010.01.029</idno><idno type="RBID">pubmed:20138453</idno><idno type="pmid">20138453</idno><idno type="wicri:Area/PubMed/Corpus">000023</idno><idno type="wicri:Area/PubMed/Curation">000014</idno><idno type="wicri:Area/PubMed/Checkpoint">000015</idno><idno type="wicri:Area/Ncbi/Merge">000041</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations.</title><author><name sortKey="Gabbanini, Simone" sort="Gabbanini, Simone" uniqKey="Gabbanini S" first="Simone" last="Gabbanini">Simone Gabbanini</name><affiliation wicri:level="1"><nlm:affiliation>BeC S.r.l., R&D division, Via C. Monteverdi 49, 47100 Forlì, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>BeC S.r.l., R&D division, Via C. Monteverdi 49, 47100 Forlì</wicri:regionArea><wicri:noRegion>47100 Forlì</wicri:noRegion></affiliation></author><author><name sortKey="Matera, Riccardo" sort="Matera, Riccardo" uniqKey="Matera R" first="Riccardo" last="Matera">Riccardo Matera</name></author><author><name sortKey="Beltramini, Claudia" sort="Beltramini, Claudia" uniqKey="Beltramini C" first="Claudia" last="Beltramini">Claudia Beltramini</name></author><author><name sortKey="Minghetti, Andrea" sort="Minghetti, Andrea" uniqKey="Minghetti A" first="Andrea" last="Minghetti">Andrea Minghetti</name></author><author><name sortKey="Valgimigli, Luca" sort="Valgimigli, Luca" uniqKey="Valgimigli L" first="Luca" last="Valgimigli">Luca Valgimigli</name></author></analytic><series><title level="j">Journal of pharmaceutical and biomedical analysis</title><idno type="eISSN">1873-264X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemistry, Pharmaceutical (methods)</term><term>Cosmetics (administration & dosage)</term><term>Cosmetics (chemistry)</term><term>Cosmetics (pharmacokinetics)</term><term>Epidermis (drug effects)</term><term>Epidermis (metabolism)</term><term>Humans</term><term>Membranes, Artificial</term><term>Skin Absorption (drug effects)</term><term>Skin Absorption (physiology)</term><term>Vitamins (administration & dosage)</term><term>Vitamins (chemistry)</term><term>Vitamins (pharmacokinetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cosmetics</term><term>Vitamins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cosmetics</term><term>Vitamins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Epidermis</term><term>Skin Absorption</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epidermis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chemistry, Pharmaceutical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Cosmetics</term><term>Vitamins</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Skin Absorption</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Membranes, Artificial</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A convenient method for in vitro investigation of the release of lipid- and water-soluble vitamins from cosmetic formulations was developed. The permeation of (d)-alpha-tocopherol (vitamin E), retinyl acetate (pro-vitamin A), ascorbic acid (vitamin C) and pyridoxine (vitamin B6) through SkinEthic reconstructed human epidermis (RHE), and synthetic polyethersulfone and polycarbonate membranes was studied in vitro using a Franz-type diffusion apparatus, coupled either to a spectrophotometer for continuous reading (dynamic setting) or to HPLC-DAD analysis of the receptor medium (static setting). O/W and W/O emulsions were compared with simple aqueous solutions for their kinetic of vitamins release, to evaluate the influence of the cosmetic formulation on the bioavailability of active ingredients. Results indicate that synthetic membranes offer a limited barrier to the diffusion of vitamins, but may provide information on the release ability of the formulation. Penetration was more effective when water was the external phase of the formulation, i.e. W/O emulsions were less effective in the release of vitamins than O/W emulsion or aqueous solutions. RHE (17 days old) offered a significantly higher barrier to penetration of vitamins, as expected for native human epidermis. The relative ranking in coefficient of permeability (Ps (cm/h)) was: ascorbic acid>pyridoxine>retinyl acetate>alpha-tocopherol approximately 0, the absolute values depending on the formulation. The method herein described showed to be a practical and convenient tool for the quality-control and efficacy evaluation of cosmetic formulations.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20138453</PMID><DateCreated><Year>2010</Year><Month>03</Month><Day>15</Day></DateCreated><DateCompleted><Year>2010</Year><Month>09</Month><Day>30</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-264X</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><Issue>4</Issue><PubDate><Year>2010</Year><Month>Aug</Month><Day>1</Day></PubDate></JournalIssue><Title>Journal of pharmaceutical and biomedical analysis</Title><ISOAbbreviation>J Pharm Biomed Anal</ISOAbbreviation></Journal><ArticleTitle>Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations.</ArticleTitle><Pagination><MedlinePgn>461-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jpba.2010.01.029</ELocationID><Abstract><AbstractText>A convenient method for in vitro investigation of the release of lipid- and water-soluble vitamins from cosmetic formulations was developed. The permeation of (d)-alpha-tocopherol (vitamin E), retinyl acetate (pro-vitamin A), ascorbic acid (vitamin C) and pyridoxine (vitamin B6) through SkinEthic reconstructed human epidermis (RHE), and synthetic polyethersulfone and polycarbonate membranes was studied in vitro using a Franz-type diffusion apparatus, coupled either to a spectrophotometer for continuous reading (dynamic setting) or to HPLC-DAD analysis of the receptor medium (static setting). O/W and W/O emulsions were compared with simple aqueous solutions for their kinetic of vitamins release, to evaluate the influence of the cosmetic formulation on the bioavailability of active ingredients. Results indicate that synthetic membranes offer a limited barrier to the diffusion of vitamins, but may provide information on the release ability of the formulation. Penetration was more effective when water was the external phase of the formulation, i.e. W/O emulsions were less effective in the release of vitamins than O/W emulsion or aqueous solutions. RHE (17 days old) offered a significantly higher barrier to penetration of vitamins, as expected for native human epidermis. The relative ranking in coefficient of permeability (Ps (cm/h)) was: ascorbic acid>pyridoxine>retinyl acetate>alpha-tocopherol approximately 0, the absolute values depending on the formulation. The method herein described showed to be a practical and convenient tool for the quality-control and efficacy evaluation of cosmetic formulations.</AbstractText><CopyrightInformation>Copyright (c) 2010 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gabbanini</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>BeC S.r.l., R&D division, Via C. Monteverdi 49, 47100 Forlì, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matera</LastName><ForeName>Riccardo</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Beltramini</LastName><ForeName>Claudia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Minghetti</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Valgimigli</LastName><ForeName>Luca</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>01</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Pharm Biomed Anal</MedlineTA><NlmUniqueID>8309336</NlmUniqueID><ISSNLinking>0731-7085</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003358">Cosmetics</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008567">Membranes, Artificial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014815">Vitamins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002626">Chemistry, Pharmaceutical</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003358">Cosmetics</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004817">Epidermis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008567">Membranes, Artificial</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012869">Skin Absorption</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014815">Vitamins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>9</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>1</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>1</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>1</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0731-7085(10)00050-6</ArticleId><ArticleId IdType="doi">10.1016/j.jpba.2010.01.029</ArticleId><ArticleId IdType="pubmed">20138453</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Beltramini, Claudia" sort="Beltramini, Claudia" uniqKey="Beltramini C" first="Claudia" last="Beltramini">Claudia Beltramini</name><name sortKey="Matera, Riccardo" sort="Matera, Riccardo" uniqKey="Matera R" first="Riccardo" last="Matera">Riccardo Matera</name><name sortKey="Minghetti, Andrea" sort="Minghetti, Andrea" uniqKey="Minghetti A" first="Andrea" last="Minghetti">Andrea Minghetti</name><name sortKey="Valgimigli, Luca" sort="Valgimigli, Luca" uniqKey="Valgimigli L" first="Luca" last="Valgimigli">Luca Valgimigli</name></noCountry><country name="Italie"><noRegion><name sortKey="Gabbanini, Simone" sort="Gabbanini, Simone" uniqKey="Gabbanini S" first="Simone" last="Gabbanini">Simone Gabbanini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/MonteverdiV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000041 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000041 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= MonteverdiV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:20138453
|texte= Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:20138453" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MonteverdiV1
| This area was generated with Dilib version V0.6.21. |  |