Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency
Identifieur interne : 000192 ( Istex/Corpus ); précédent : 000191; suivant : 000193Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency
Auteurs : Ruben P. Laguens ; Ricardo Weinschelbaum ; René FavaloroSource :
- Human Pathology [ 0046-8177 ] ; 1979.
Abstract
In 13 patients with acute coronary insufficiency (intermediate syndrome, postinfarction angina, and progressive angina), samples of the ischemic area of the myocardium were studied with the electron microscope and by morphometric methods in order to describe quantitatively the mitochondrial population. Three indices were measured: the fractional volume of the mitochondrial compartment of the cytoplasm, the number of mitochondria per unit volume of heart tissue, and the average individual mitochondrial volume. As a control, the same study was performed on samples obtained from patients with chronic coronary insufficiency and mitral stenosis.In all the ischemic hearts the most conspicuous ultrastructural modification of the muscle cells consisted in an irregular distribution of the mitochondria within the muscle cells and an increase in the number of glycogen and lipofuscin granules. Generally, odd shaped mitochondria were found. The modifications were not diffuse, and almost normal heart muscle cells were seen alongside deeply altered ones.In addition a definite decrease in the fractional volume of the mitochondrial compartment was found, which was apparently due to a decrease in the number of mitochondria per unit volume of cytoplasm. The average individual mitochondrial volume was similar in acute coronary insufficiency and in the control cases.On the basis of this evidence it is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.
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DOI: 10.1016/S0046-8177(79)80113-6
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency</title><author><name sortKey="Laguens, Ruben P" sort="Laguens, Ruben P" uniqKey="Laguens R" first="Ruben P." last="Laguens">Ruben P. Laguens</name><affiliation><mods:affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</mods:affiliation></affiliation></author><author><name sortKey="Weinschelbaum, Ricardo" sort="Weinschelbaum, Ricardo" uniqKey="Weinschelbaum R" first="Ricardo" last="Weinschelbaum">Ricardo Weinschelbaum</name><affiliation><mods:affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</mods:affiliation></affiliation></author><author><name sortKey="Favaloro, Rene" sort="Favaloro, Rene" uniqKey="Favaloro R" first="René" last="Favaloro">René Favaloro</name><affiliation><mods:affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9DA1CEAED9A8EBE14E153FC4E4621C9681FACD02</idno><date when="1979" year="1979">1979</date><idno type="doi">10.1016/S0046-8177(79)80113-6</idno><idno type="url">https://api.istex.fr/document/9DA1CEAED9A8EBE14E153FC4E4621C9681FACD02/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000192</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000192</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency</title><author><name sortKey="Laguens, Ruben P" sort="Laguens, Ruben P" uniqKey="Laguens R" first="Ruben P." last="Laguens">Ruben P. Laguens</name><affiliation><mods:affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</mods:affiliation></affiliation></author><author><name sortKey="Weinschelbaum, Ricardo" sort="Weinschelbaum, Ricardo" uniqKey="Weinschelbaum R" first="Ricardo" last="Weinschelbaum">Ricardo Weinschelbaum</name><affiliation><mods:affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</mods:affiliation></affiliation></author><author><name sortKey="Favaloro, Rene" sort="Favaloro, Rene" uniqKey="Favaloro R" first="René" last="Favaloro">René Favaloro</name><affiliation><mods:affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Pathology</title><title level="j" type="abbrev">YHUPA</title><idno type="ISSN">0046-8177</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1979">1979</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="695">695</biblScope><biblScope unit="page" to="705">705</biblScope></imprint><idno type="ISSN">0046-8177</idno></series><idno type="istex">9DA1CEAED9A8EBE14E153FC4E4621C9681FACD02</idno><idno type="DOI">10.1016/S0046-8177(79)80113-6</idno><idno type="PII">S0046-8177(79)80113-6</idno><idno type="ArticleID">80113</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0046-8177</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 13 patients with acute coronary insufficiency (intermediate syndrome, postinfarction angina, and progressive angina), samples of the ischemic area of the myocardium were studied with the electron microscope and by morphometric methods in order to describe quantitatively the mitochondrial population. Three indices were measured: the fractional volume of the mitochondrial compartment of the cytoplasm, the number of mitochondria per unit volume of heart tissue, and the average individual mitochondrial volume. As a control, the same study was performed on samples obtained from patients with chronic coronary insufficiency and mitral stenosis.In all the ischemic hearts the most conspicuous ultrastructural modification of the muscle cells consisted in an irregular distribution of the mitochondria within the muscle cells and an increase in the number of glycogen and lipofuscin granules. Generally, odd shaped mitochondria were found. The modifications were not diffuse, and almost normal heart muscle cells were seen alongside deeply altered ones.In addition a definite decrease in the fractional volume of the mitochondrial compartment was found, which was apparently due to a decrease in the number of mitochondria per unit volume of cytoplasm. The average individual mitochondrial volume was similar in acute coronary insufficiency and in the control cases.On the basis of this evidence it is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Ruben P. Laguens M.D.</name><affiliations><json:string>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</json:string></affiliations></json:item><json:item><name>Ricardo Weinschelbaum M.D.</name><affiliations><json:string>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</json:string></affiliations></json:item><json:item><name>René Favaloro M.D.</name><affiliations><json:string>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</json:string></affiliations></json:item></author><articleId><json:string>80113</json:string></articleId><language><json:string>eng</json:string></language><abstract>In 13 patients with acute coronary insufficiency (intermediate syndrome, postinfarction angina, and progressive angina), samples of the ischemic area of the myocardium were studied with the electron microscope and by morphometric methods in order to describe quantitatively the mitochondrial population. Three indices were measured: the fractional volume of the mitochondrial compartment of the cytoplasm, the number of mitochondria per unit volume of heart tissue, and the average individual mitochondrial volume. As a control, the same study was performed on samples obtained from patients with chronic coronary insufficiency and mitral stenosis.In all the ischemic hearts the most conspicuous ultrastructural modification of the muscle cells consisted in an irregular distribution of the mitochondria within the muscle cells and an increase in the number of glycogen and lipofuscin granules. Generally, odd shaped mitochondria were found. The modifications were not diffuse, and almost normal heart muscle cells were seen alongside deeply altered ones.In addition a definite decrease in the fractional volume of the mitochondrial compartment was found, which was apparently due to a decrease in the number of mitochondria per unit volume of cytoplasm. The average individual mitochondrial volume was similar in acute coronary insufficiency and in the control cases.On the basis of this evidence it is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.</abstract><qualityIndicators><score>6.15</score><pdfVersion>1.4</pdfVersion><pdfPageSize>594.72 x 841.68 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1597</abstractCharCount><pdfWordCount>2878</pdfWordCount><pdfCharCount>19107</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>231</abstractWordCount></qualityIndicators><title>Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency</title><pii><json:string>S0046-8177(79)80113-6</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>Vol. 5</volume><editor><json:item><name>G. 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Three indices were measured: the fractional volume of the mitochondrial compartment of the cytoplasm, the number of mitochondria per unit volume of heart tissue, and the average individual mitochondrial volume. As a control, the same study was performed on samples obtained from patients with chronic coronary insufficiency and mitral stenosis.In all the ischemic hearts the most conspicuous ultrastructural modification of the muscle cells consisted in an irregular distribution of the mitochondria within the muscle cells and an increase in the number of glycogen and lipofuscin granules. Generally, odd shaped mitochondria were found. The modifications were not diffuse, and almost normal heart muscle cells were seen alongside deeply altered ones.In addition a definite decrease in the fractional volume of the mitochondrial compartment was found, which was apparently due to a decrease in the number of mitochondria per unit volume of cytoplasm. The average individual mitochondrial volume was similar in acute coronary insufficiency and in the control cases.On the basis of this evidence it is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.</p></abstract></profileDesc><revisionDesc><change when="1979">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YHUPA</jid><aid>80113</aid><ce:pii>S0046-8177(79)80113-6</ce:pii><ce:doi>10.1016/S0046-8177(79)80113-6</ce:doi><ce:copyright type="unknown" year="1979">W. B. Saunders Company.</ce:copyright></item-info><head><ce:title>Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency</ce:title><ce:author-group><ce:author><ce:given-name>Ruben P.</ce:given-name><ce:surname>Laguens</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="fn1"><ce:sup>*</ce:sup></ce:cross-ref><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Ricardo</ce:given-name><ce:surname>Weinschelbaum</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="fn2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>René</ce:given-name><ce:surname>Favaloro</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="fn3"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>a</ce:label><ce:textfn>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</ce:textfn></ce:affiliation><ce:footnote id="fn1"><ce:label>*</ce:label><ce:note-para>Professor of Pathology, School of Medicine, Universidad Nacional de La Plata, La Plata, Argentina.</ce:note-para></ce:footnote><ce:footnote id="fn2"><ce:label>†</ce:label><ce:note-para>Assistant in Surgery, Department of Cardiovascular Surgery, Sanatorio Güemes, Buenos Aires, Argentina.</ce:note-para></ce:footnote><ce:footnote id="fn3"><ce:label>‡</ce:label><ce:note-para>Chief, Department of Cardiovascular Surgery, Sanatorio Güemes, Buenos Aires, Argentina.</ce:note-para></ce:footnote></ce:author-group><ce:abstract id="ab1"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>In 13 patients with acute coronary insufficiency (intermediate syndrome, postinfarction angina, and progressive angina), samples of the ischemic area of the myocardium were studied with the electron microscope and by morphometric methods in order to describe quantitatively the mitochondrial population. Three indices were measured: the fractional volume of the mitochondrial compartment of the cytoplasm, the number of mitochondria per unit volume of heart tissue, and the average individual mitochondrial volume. As a control, the same study was performed on samples obtained from patients with chronic coronary insufficiency and mitral stenosis.</ce:simple-para><ce:simple-para>In all the ischemic hearts the most conspicuous ultrastructural modification of the muscle cells consisted in an irregular distribution of the mitochondria within the muscle cells and an increase in the number of glycogen and lipofuscin granules. Generally, odd shaped mitochondria were found. The modifications were not diffuse, and almost normal heart muscle cells were seen alongside deeply altered ones.</ce:simple-para><ce:simple-para>In addition a definite decrease in the fractional volume of the mitochondrial compartment was found, which was apparently due to a decrease in the number of mitochondria per unit volume of cytoplasm. The average individual mitochondrial volume was similar in acute coronary insufficiency and in the control cases.</ce:simple-para><ce:simple-para>On the basis of this evidence it is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.</ce:simple-para></ce:abstract-sec></ce:abstract></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:given-name>F.</ce:given-name><ce:surname>Buchner</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Qualitative morphology of heart failure. 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Path.</sb:maintitle></sb:title><sb:volume-nr>79</sb:volume-nr></sb:series><sb:date>1965</sb:date></sb:issue><sb:pages><sb:first-page>135</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency</title></titleInfo><name type="personal"><namePart type="given">Ruben P.</namePart><namePart type="family">Laguens</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</affiliation><description>Professor of Pathology, School of Medicine, Universidad Nacional de La Plata, La Plata, Argentina.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ricardo</namePart><namePart type="family">Weinschelbaum</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</affiliation><description>Assistant in Surgery, Department of Cardiovascular Surgery, Sanatorio Güemes, Buenos Aires, Argentina.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">René</namePart><namePart type="family">Favaloro</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Centro de Investigaciones Cardiovasculares Facultad de Medicina Universidad Nacional de la Plata La Plata-1900 Argentina</affiliation><description>Chief, Department of Cardiovascular Surgery, Sanatorio Güemes, Buenos Aires, Argentina.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1979</dateIssued><copyrightDate encoding="w3cdtf">1979</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">In 13 patients with acute coronary insufficiency (intermediate syndrome, postinfarction angina, and progressive angina), samples of the ischemic area of the myocardium were studied with the electron microscope and by morphometric methods in order to describe quantitatively the mitochondrial population. Three indices were measured: the fractional volume of the mitochondrial compartment of the cytoplasm, the number of mitochondria per unit volume of heart tissue, and the average individual mitochondrial volume. As a control, the same study was performed on samples obtained from patients with chronic coronary insufficiency and mitral stenosis.In all the ischemic hearts the most conspicuous ultrastructural modification of the muscle cells consisted in an irregular distribution of the mitochondria within the muscle cells and an increase in the number of glycogen and lipofuscin granules. Generally, odd shaped mitochondria were found. The modifications were not diffuse, and almost normal heart muscle cells were seen alongside deeply altered ones.In addition a definite decrease in the fractional volume of the mitochondrial compartment was found, which was apparently due to a decrease in the number of mitochondria per unit volume of cytoplasm. The average individual mitochondrial volume was similar in acute coronary insufficiency and in the control cases.On the basis of this evidence it is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.</abstract><relatedItem type="host"><titleInfo><title>Human Pathology</title></titleInfo><titleInfo type="abbreviated"><title>YHUPA</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197911</dateIssued></originInfo><identifier type="ISSN">0046-8177</identifier><identifier type="PII">S0046-8177(79)X8107-5</identifier><part><detail type="volume"><number>10</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue pages"><start>617</start><end>750</end></extent><extent unit="pages"><start>695</start><end>705</end></extent></part></relatedItem><identifier type="istex">9DA1CEAED9A8EBE14E153FC4E4621C9681FACD02</identifier><identifier type="DOI">10.1016/S0046-8177(79)80113-6</identifier><identifier type="PII">S0046-8177(79)80113-6</identifier><identifier type="ArticleID">80113</identifier><accessCondition type="use and reproduction" contentType="">© 1979W. B. Saunders Company.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>W. B. Saunders Company., ©1979</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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